IL23R Antibody - #DF6501
| 製品: | IL23R Antibody |
| カタログ: | DF6501 |
| タンパク質の説明: | Rabbit polyclonal antibody to IL23R |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 69kDa; 72kD(Calculated). |
| ユニプロット: | Q5VWK5 |
| RRID: | AB_2838463 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF6501, RRID:AB_2838463.
折りたたみ／展開
IL 23R; IL-23 receptor; IL-23R; Il23r; IL23R_HUMAN; Interleukin 23 receptor; Interleukin-23 receptor;
免疫原
Expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells.
- Q5VWK5 IL23R_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MNQVTIQWDAVIALYILFSWCHGGITNINCSGHIWVEPATIFKMGMNISIYCQAAIKNCQPRKLHFYKNGIKERFQITRINKTTARLWYKNFLEPHASMYCTAECPKHFQETLICGKDISSGYPPDIPDEVTCVIYEYSGNMTCTWNAGKLTYIDTKYVVHVKSLETEEEQQYLTSSYINISTDSLQGGKKYLVWVQAANALGMEESKQLQIHLDDIVIPSAAVISRAETINATVPKTIIYWDSQTTIEKVSCEMRYKATTNQTWNVKEFDTNFTYVQQSEFYLEPNIKYVFQVRCQETGKRYWQPWSSLFFHKTPETVPQVTSKAFQHDTWNSGLTVASISTGHLTSDNRGDIGLLLGMIVFAVMLSILSLIGIFNRSFRTGIKRRILLLIPKWLYEDIPNMKNSNVVKMLQENSELMNNNSSEQVLYVDPMITEIKEIFIPEHKPTDYKKENTGPLETRDYPQNSLFDNTTVVYIPDLNTGYKPQISNFLPEGSHLSNNNEITSLTLKPPVDSLDSGNNPRLQKHPNFAFSVSSVNSLSNTIFLGELSLILNQGECSSPDIQNSVEEETTMLLENDSPSETIPEQTLLPDEFVSCLGIVNEELPSINTYFPQNILESHFNRISLLEK
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q5VWK5 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| N29 | N-Glycosylation | Uniprot | |
| N47 | N-Glycosylation | Uniprot | |
| Y51 | Phosphorylation | Uniprot | |
| N81 | N-Glycosylation | Uniprot | |
| T112 | Phosphorylation | Uniprot | |
| S120 | Phosphorylation | Uniprot | |
| S121 | Phosphorylation | Uniprot | |
| N141 | N-Glycosylation | Uniprot | |
| S177 | Phosphorylation | Uniprot | |
| Y178 | Phosphorylation | Uniprot | |
| N180 | N-Glycosylation | Uniprot | |
| N232 | N-Glycosylation | Uniprot | |
| T234 | Phosphorylation | Uniprot | |
| N262 | N-Glycosylation | Uniprot | |
| N273 | N-Glycosylation | Uniprot | |
| T455 | Phosphorylation | Uniprot | |
| T460 | Phosphorylation | Uniprot |
研究背景
Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.
Phosphorylated in response to IL23.
Cell membrane>Single-pass type I membrane protein.
Expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells.
Heterodimer with IL12RB1. In presence of IL23, the heterodimer forms the IL23 receptor. Interacts with JAK2 and in presence of IL23 with STAT3.
Belongs to the type I cytokine receptor family. Type 2 subfamily.
研究領域
· Environmental Information Processing > Signaling molecules and interaction > Cytokine-cytokine receptor interaction. (View pathway)
· Environmental Information Processing > Signal transduction > Jak-STAT signaling pathway. (View pathway)
· Human Diseases > Cancers: Overview > Pathways in cancer. (View pathway)
· Human Diseases > Immune diseases > Inflammatory bowel disease (IBD).
· Organismal Systems > Immune system > Th17 cell differentiation. (View pathway)
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