DPYD Antibody - #DF6507
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF6507, RRID:AB_2838469.
折りたたみ／展開
DHP; DHPDHase; Dihydropyrimidine dehydrogenase [NADP(+)]; Dihydropyrimidine dehydrogenase [NADP+]; Dihydropyrimidine dehydrogenase; Dihydrothymine dehydrogenase; Dihydrouracil dehydrogenase; DPD; DPYD; DPYD_HUMAN; MGC132008; MGC70799; OTTHUMP00000058954;
免疫原
Found in most tissues with greatest activity found in liver and peripheral blood mononuclear cells.
- Q12882 DPYD_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAPVLSKDSADIESILALNPRTQTHATLCSTSAKKLDKKHWKRNPDKNCFNCEKLENNFDDIKHTTLGERGALREAMRCLKCADAPCQKSCPTNLDIKSFITSIANKNYYGAAKMIFSDNPLGLTCGMVCPTSDLCVGGCNLYATEEGPINIGGLQQFATEVFKAMSIPQIRNPSLPPPEKMSEAYSAKIALFGAGPASISCASFLARLGYSDITIFEKQEYVGGLSTSEIPQFRLPYDVVNFEIELMKDLGVKIICGKSLSVNEMTLSTLKEKGYKAAFIGIGLPEPNKDAIFQGLTQDQGFYTSKDFLPLVAKGSKAGMCACHSPLPSIRGVVIVLGAGDTAFDCATSALRCGARRVFIVFRKGFVNIRAVPEEMELAKEEKCEFLPFLSPRKVIVKGGRIVAMQFVRTEQDETGKWNEDEDQMVHLKADVVISAFGSVLSDPKVKEALSPIKFNRWGLPEVDPETMQTSEAWVFAGGDVVGLANTTVESVNDGKQASWYIHKYVQSQYGASVSAKPELPLFYTPIDLVDISVEMAGLKFINPFGLASATPATSTSMIRRAFEAGWGFALTKTFSLDKDIVTNVSPRIIRGTTSGPMYGPGQSSFLNIELISEKTAAYWCQSVTELKADFPDNIVIASIMCSYNKNDWTELAKKSEDSGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVQIPFFAKLTPNVTDIVSIARAAKEGGANGVTATNTVSGLMGLKSDGTPWPAVGIAKRTTYGGVSGTAIRPIALRAVTSIARALPGFPILATGGIDSAESGLQFLHSGASVLQVCSAIQNQDFTVIEDYCTGLKALLYLKSIEELQDWDGQSPATVSHQKGKPVPRIAELMDKKLPSFGPYLEQRKKIIAENKIRLKEQNVAFSPLKRNCFIPKRPIPTIKDVIGKALQYLGTFGELSNVEQVVAMIDEEMCINCGKCYMTCNDSGYQAIQFDPETHLPTITDTCTGCTLCLSVCPIVDCIKMVSRTTPYEPKRGVPLSVNPVC
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q12882 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T31 | Phosphorylation | Uniprot | |
| S32 | Phosphorylation | Uniprot | |
| K35 | Acetylation | Uniprot | |
| K38 | Acetylation | Uniprot | |
| K39 | Acetylation | Uniprot | |
| K63 | Ubiquitination | Uniprot | |
| K81 | Ubiquitination | Uniprot | |
| K89 | Ubiquitination | Uniprot | |
| K98 | Ubiquitination | Uniprot | |
| S99 | Phosphorylation | Uniprot | |
| T102 | Phosphorylation | Uniprot | |
| S103 | Phosphorylation | Uniprot | |
| K107 | Ubiquitination | Uniprot | |
| S175 | Phosphorylation | Uniprot | |
| K181 | Ubiquitination | Uniprot | |
| K259 | Ubiquitination | Uniprot | |
| S260 | Phosphorylation | Uniprot | |
| S262 | Phosphorylation | Uniprot | |
| K272 | Ubiquitination | Uniprot | |
| K307 | Ubiquitination | Uniprot | |
| K315 | Ubiquitination | Uniprot | |
| K318 | Ubiquitination | Uniprot | |
| S326 | Phosphorylation | Uniprot | |
| K365 | Ubiquitination | Uniprot | |
| K381 | Ubiquitination | Uniprot | |
| K384 | Acetylation | Uniprot | |
| K384 | Ubiquitination | Uniprot | |
| K418 | Ubiquitination | Uniprot | |
| S436 | Phosphorylation | Uniprot | |
| S440 | Phosphorylation | Uniprot | |
| K448 | Ubiquitination | Uniprot | |
| S452 | Phosphorylation | Uniprot | |
| K455 | Ubiquitination | Uniprot | |
| T573 | Phosphorylation | Uniprot | |
| T575 | Phosphorylation | Uniprot | |
| S577 | Phosphorylation | Uniprot | |
| K580 | Ubiquitination | Uniprot | |
| S587 | Phosphorylation | Uniprot | |
| K655 | Ubiquitination | Uniprot | |
| K656 | Ubiquitination | Uniprot | |
| K709 | Ubiquitination | Uniprot | |
| K725 | Ubiquitination | Uniprot | |
| K758 | Ubiquitination | Uniprot | |
| Y762 | Phosphorylation | Uniprot | |
| S766 | Phosphorylation | Uniprot | |
| T768 | Phosphorylation | Uniprot | |
| K841 | Ubiquitination | Uniprot | |
| K875 | Ubiquitination | Uniprot | |
| K888 | Ubiquitination | Uniprot | |
| K894 | Ubiquitination | Uniprot | |
| K898 | Methylation | Uniprot | |
| K898 | Ubiquitination | Uniprot | |
| S905 | Phosphorylation | Uniprot | |
| K908 | Methylation | Uniprot | |
| K908 | Ubiquitination | Uniprot | |
| K915 | Ubiquitination | Uniprot | |
| K922 | Ubiquitination | Uniprot |
研究背景
Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil.
Cytoplasm.
Found in most tissues with greatest activity found in liver and peripheral blood mononuclear cells.
Homodimer.
Belongs to the dihydropyrimidine dehydrogenase family.
研究領域
· Metabolism > Nucleotide metabolism > Pyrimidine metabolism.
· Metabolism > Metabolism of other amino acids > beta-Alanine metabolism.
· Metabolism > Metabolism of cofactors and vitamins > Pantothenate and CoA biosynthesis.
· Metabolism > Xenobiotics biodegradation and metabolism > Drug metabolism - other enzymes.
· Metabolism > Global and overview maps > Metabolic pathways.
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