SELL Antibody - #DF6509
| 製品: | SELL Antibody |
| カタログ: | DF6509 |
| タンパク質の説明: | Rabbit polyclonal antibody to SELL |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 42kDa; 42kD(Calculated). |
| ユニプロット: | P14151 |
| RRID: | AB_2838471 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF6509, RRID:AB_2838471.
折りたたみ／展開
A.11; AI528707; CD62 antigen ligand; CD62 antigen-like family member L; CD62L; gp90-MEL; IgA nephropathy, susceptibility to, included; L Selectin; L-selectin; LAM-1; LAM1; LECAM1; LEU8; Leukocyte adhesion molecule 1; Leukocyte surface antigen Leu-8; Leukocyte-endothelial cell adhesion molecule 1; Lnhr; LSEL; Ly-22; Ly-m22; Lyam-1; LYAM1; LYAM1_HUMAN; Lymph node homing receptor; Lymphocyte adhesion molecule 1; Lymphocyte antigen 22; Lymphocyte surface MEL-14 antigen; MEL-14; Pln homing receptor; PLNHR; Selectin L; Selectin, lymphocyte; SELL; TQ1;
免疫原
- P14151 LYAM1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MIFPWKCQSTQRDLWNIFKLWGWTMLCCDFLAHHGTDCWTYHYSEKPMNWQRARRFCRDNYTDLVAIQNKAEIEYLEKTLPFSRSYYWIGIRKIGGIWTWVGTNKSLTEEAENWGDGEPNNKKNKEDCVEIYIKRNKDAGKWNDDACHKLKAALCYTASCQPWSCSGHGECVEIINNYTCNCDVGYYGPQCQFVIQCEPLEAPELGTMDCTHPLGNFSFSSQCAFSCSEGTNLTGIEETTCGPFGNWSSPEPTCQVIQCEPLSAPDLGIMNCSHPLASFSFTSACTFICSEGTELIGKKKTICESSGIWSNPSPICQKLDKSFSMIKEGDYNPLFIPVAVMVTAFSGLAFIIWLARRLKKGKKSKRSMNDPY
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P14151 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| N60 | N-Glycosylation | Uniprot | |
| K78 | Ubiquitination | Uniprot | |
| K93 | Ubiquitination | Uniprot | |
| N104 | N-Glycosylation | Uniprot | |
| K105 | Ubiquitination | Uniprot | |
| K122 | Ubiquitination | Uniprot | |
| K125 | Ubiquitination | Uniprot | |
| Y132 | Phosphorylation | Uniprot | |
| K134 | Ubiquitination | Uniprot | |
| K137 | Ubiquitination | Uniprot | |
| K141 | Ubiquitination | Uniprot | |
| K149 | Ubiquitination | Uniprot | |
| N177 | N-Glycosylation | Uniprot | |
| K300 | Ubiquitination | Uniprot | |
| K318 | Ubiquitination | Uniprot | |
| K321 | Ubiquitination | Uniprot | |
| S364 | Phosphorylation | Uniprot | |
| S367 | Phosphorylation | Uniprot |
研究背景
Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.
N-glycosylated.
Cell membrane>Single-pass type I membrane protein.
Expressed in B-cell lines and T-lymphocytes.
Interaction with SELPLG/PSGL1 and PODXL2 is required for promoting recruitment and rolling of leukocytes. This interaction is dependent on the sialyl Lewis X glycan modification of SELPLG and PODXL2, and tyrosine sulfation modifications of SELPLG. Sulfation on 'Tyr-51' of SELPLG is important for L-selectin binding.
Belongs to the selectin/LECAM family.
研究領域
· Environmental Information Processing > Signaling molecules and interaction > Cell adhesion molecules (CAMs). (View pathway)
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