TFPI Antibody - #DF6511
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF6511, RRID:AB_2838473.
折りたたみ／展開
Anti convertin; EPI; Extrinsic pathway inhibitor; LACI; Lipoprotein associated coagulation inhibitor; Lipoprotein-associated coagulation inhibitor; TFI; TFPI 1; TFPI; TFPI1; TFPI1_HUMAN; Tissue factor pathway inhibitor (lipoprotein associated coagulation inhibitor); Tissue factor pathway inhibitor;
免疫原
- P10646 TFPI1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MIYTMKKVHALWASVCLLLNLAPAPLNADSEEDEEHTIITDTELPPLKLMHSFCAFKADDGPCKAIMKRFFFNIFTRQCEEFIYGGCEGNQNRFESLEECKKMCTRDNANRIIKTTLQQEKPDFCFLEEDPGICRGYITRYFYNNQTKQCERFKYGGCLGNMNNFETLEECKNICEDGPNGFQVDNYGTQLNAVNNSLTPQSTKVPSLFEFHGPSWCLTPADRGLCRANENRFYYNSVIGKCRPFKYSGCGGNENNFTSKQECLRACKKGFIQRISKGGLIKTKRKRKKQRVKIAYEEIFVKNM
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P10646 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S30 | Phosphorylation | P68400 (CSNK2A1) | Uniprot |
| T42 | O-Glycosylation | Uniprot | |
| T115 | O-Glycosylation | Uniprot | |
| T116 | O-Glycosylation | Uniprot | |
| K121 | Ubiquitination | Uniprot | |
| N145 | N-Glycosylation | Uniprot | |
| N195 | N-Glycosylation | Uniprot | |
| S202 | O-Glycosylation | Uniprot | |
| S202 | Phosphorylation | P28482 (MAPK1) | Uniprot |
| T203 | O-Glycosylation | Uniprot | |
| T219 | Phosphorylation | Uniprot | |
| K260 | Ubiquitination | Uniprot | |
| K268 | Acetylation | Uniprot | |
| K269 | Acetylation | Uniprot | |
| K269 | Sumoylation | Uniprot | |
| K293 | Sumoylation | Uniprot |
研究背景
Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.
O-glycosylated.
Secreted.
Microsome membrane>Lipid-anchor.
Mostly in endothelial cells.
This inhibitor contains three inhibitory domains. The first domain interacts with VIIa and TF, the second one with Xa.
研究領域
· Organismal Systems > Immune system > Complement and coagulation cascades. (View pathway)
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