KIR2DL1 Antibody - #DF6560

(2)  
製品: KIR2DL1 Antibody
カタログ: DF6560
タンパク質の説明: Rabbit polyclonal antibody to KIR2DL1
アプリケーション: WB IHC IF/ICC
反応性: Human, Mouse
分子量: 39kDa; 39kD(Calculated).
ユニプロット: P43626
RRID: AB_2838522

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MS Report
HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse
クローナリティ:
Polyclonal
特異性:
KIR2DL1 Antibody detects endogenous levels of total KIR2DL1.
RRID:
AB_2838522
引用形式: Affinity Biosciences Cat# DF6560, RRID:AB_2838522.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

CD158 antigen-like family member A; CD158a; KI2L1_HUMAN; Killer cell immunoglobulin like receptor two domains long cytoplasmic tail 1; Killer cell immunoglobulin-like receptor 2DL1; KIR-K64; KIR221; KIR2DL1; MHC class I NK cell receptor; Natural killer-associated transcript 1; NKAT 1; NKAT; NKAT-1; p58 natural killer cell receptor clones CL-42/47.11; p58 NK receptor; p58 NK receptor CL-42/47.11; p58.1; p58.1 MHC class-I-specific NK receptor;

免疫原

免疫原:
Uniprot:

P43626(KI2L1_HUMAN) >>Visit HPA database.

遺伝子(ID):
KIR2DL1(3802)
発現特異性:
P43626 KI2L1_HUMAN:

Expressed by NK cells.

タンパク質の説明:
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several framework genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]
タンパク質配列:
MSLLVVSMACVGFFLLQGAWPHEGVHRKPSLLAHPGPLVKSEETVILQCWSDVMFEHFLLHREGMFNDTLRLIGEHHDGVSKANFSISRMTQDLAGTYRCYGSVTHSPYQVSAPSDPLDIVIIGLYEKPSLSAQPGPTVLAGENVTLSCSSRSSYDMYHLSREGEAHERRLPAGPKVNGTFQADFPLGPATHGGTYRCFGSFHDSPYEWSKSSDPLLVSVTGNPSNSWPSPTEPSSKTGNPRHLHILIGTSVVIILFILLFFLLHRWCSNKKNAAVMDQESAGNRTANSEDSDEQDPQEVTYTQLNHCVFTQRKITRPSQRPKTPPTDIIVYTELPNAESRSKVVSCP

PTMs - P43626 基板として

Site PTM Type Enzyme
S86 Phosphorylation
T97 Phosphorylation
T180 Phosphorylation
S281 Phosphorylation
Y302 Phosphorylation
T311 Phosphorylation
Y332 Phosphorylation

研究背景

機能:

Receptor on natural killer (NK) cells for some HLA-C alleles such as w4 and w6. Inhibits the activity of NK cells thus preventing cell lysis.

細胞の位置付け:

Cell membrane>Single-pass type I membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Expressed by NK cells.

サブユニット構造:

Interacts with ARRB2. Interacts with PTPN6; the interaction is enhanced by ARRB2. Interacts with PTPN11; the interaction is enhanced by ARRB2.

タンパク質ファミリー:

Belongs to the immunoglobulin superfamily.

研究領域

· Cellular Processes > Cell growth and death > Cellular senescence.   (View pathway)

· Human Diseases > Immune diseases > Graft-versus-host disease.

· Organismal Systems > Immune system > Antigen processing and presentation.   (View pathway)

· Organismal Systems > Immune system > Natural killer cell mediated cytotoxicity.   (View pathway)

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