NARG1 Antibody - #AF0528
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF0528, RRID:AB_2833796.
折りたたみ／展開
5730450D16Rik; 6330400I15; ASTBDN; GA19; Gastric cancer antigen Ga19; MGC29428; mNAT1; N alpha acetyltransferase 15, NatA auxiliary subunit; N terminal acetyltransferase; N(alpha) acetyltransferase 15, NatA auxiliary subunit; N-alpha-acetyltransferase 15; N-terminal acetyltransferase; Naa15; NAA15_HUMAN; NatA auxiliary subunit; NATH; NMDA receptor regulated 1; NMDA receptor regulated protein 1; NMDA receptor-regulated protein 1; Protein tubedown 1; Protein tubedown-1; Tbdn 1; Tbdn100; Transcriptional coactivator tubedown 100; tubedown-1;
免疫原
Expressed at high levels in testis and in ocular endothelial cells. Also found in brain (corpus callosum), heart, colon, bone marrow and at lower levels in most adult tissues, including thyroid, liver, pancreas, mammary and salivary glands, lung, ovary, urogenital system and upper gastrointestinal tract. Overexpressed in gastric cancer, in papillary thyroid carcinomas and in a Burkitt lymphoma cell line (Daudi). Specifically suppressed in abnormal proliferating blood vessels in eyes of patients with proliferative diabetic retinopathy.
- Q9BXJ9 NAA15_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPAVSLPPKENALFKRILRCYEHKQYRNGLKFCKQILSNPKFAEHGETLAMKGLTLNCLGKKEEAYELVRRGLRNDLKSHVCWHVYGLLQRSDKKYDEAIKCYRNALKWDKDNLQILRDLSLLQIQMRDLEGYRETRYQLLQLRPAQRASWIGYAIAYHLLEDYEMAAKILEEFRKTQQTSPDKVDYEYSELLLYQNQVLREAGLYREALEHLCTYEKQICDKLAVEETKGELLLQLCRLEDAADVYRGLQERNPENWAYYKGLEKALKPANMLERLKIYEEAWTKYPRGLVPRRLPLNFLSGEKFKECLDKFLRMNFSKGCPPVFNTLRSLYKDKEKVAIIEELVVGYETSLKSCRLFNPNDDGKEEPPTTLLWVQYYLAQHYDKIGQPSIALEYINTAIESTPTLIELFLVKAKIYKHAGNIKEAARWMDEAQALDTADRFINSKCAKYMLKANLIKEAEEMCSKFTREGTSAVENLNEMQCMWFQTECAQAYKAMNKFGEALKKCHEIERHFIEITDDQFDFHTYCMRKITLRSYVDLLKLEDVLRQHPFYFKAARIAIEIYLKLHDNPLTDENKEHEADTANMSDKELKKLRNKQRRAQKKAQIEEEKKNAEKEKQQRNQKKKKDDDDEEIGGPKEELIPEKLAKVETPLEEAIKFLTPLKNLVKNKIETHLFAFEIYFRKEKFLLMLQSVKRAFAIDSSHPWLHECMIRLFNTAVCESKDLSDTVRTVLKQEMNRLFGATNPKNFNETFLKRNSDSLPHRLSAAKMVYYLDPSSQKRAIELATTLDESLTNRNLQTCMEVLEALYDGSLGDCKEAAEIYRANCHKLFPYALAFMPPGYEEDMKITVNGDSSAEAEELANEI
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9BXJ9 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K9 | Ubiquitination | Uniprot | |
| K34 | Acetylation | Uniprot | |
| K34 | Ubiquitination | Uniprot | |
| K41 | Acetylation | Uniprot | |
| K41 | Ubiquitination | Uniprot | |
| K52 | Ubiquitination | Uniprot | |
| K61 | Ubiquitination | Uniprot | |
| K62 | Acetylation | Uniprot | |
| K62 | Ubiquitination | Uniprot | |
| Y66 | Phosphorylation | Uniprot | |
| Y86 | Phosphorylation | Uniprot | |
| K94 | Ubiquitination | Uniprot | |
| K101 | Ubiquitination | Uniprot | |
| T177 | Phosphorylation | Uniprot | |
| T180 | Phosphorylation | Uniprot | |
| K184 | Ubiquitination | Uniprot | |
| K223 | Ubiquitination | Uniprot | |
| K230 | Ubiquitination | Uniprot | |
| Y247 | Phosphorylation | Uniprot | |
| K262 | Acetylation | Uniprot | |
| K262 | Ubiquitination | Uniprot | |
| K266 | Ubiquitination | Uniprot | |
| K269 | Ubiquitination | Uniprot | |
| K278 | Ubiquitination | Uniprot | |
| Y280 | Phosphorylation | Uniprot | |
| K286 | Ubiquitination | Uniprot | |
| S302 | Phosphorylation | Uniprot | |
| K307 | Ubiquitination | Uniprot | |
| K312 | Ubiquitination | Uniprot | |
| K419 | Ubiquitination | Uniprot | |
| K425 | Ubiquitination | Uniprot | |
| R442 | Methylation | Uniprot | |
| K447 | Ubiquitination | Uniprot | |
| K454 | Ubiquitination | Uniprot | |
| K459 | Ubiquitination | Uniprot | |
| K467 | Ubiquitination | Uniprot | |
| K496 | Ubiquitination | Uniprot | |
| S537 | Phosphorylation | Uniprot | |
| Y538 | Phosphorylation | Uniprot | |
| K543 | Ubiquitination | Uniprot | |
| T584 | Phosphorylation | Uniprot | |
| S588 | Phosphorylation | Uniprot | |
| K646 | Ubiquitination | Uniprot | |
| K649 | Ubiquitination | Uniprot | |
| K659 | Ubiquitination | Uniprot | |
| T662 | Phosphorylation | Uniprot | |
| K665 | Ubiquitination | Uniprot | |
| C721 | S-Nitrosylation | Uniprot | |
| K724 | Acetylation | Uniprot | |
| K724 | Ubiquitination | Uniprot | |
| K735 | Acetylation | Uniprot | |
| K735 | Ubiquitination | Uniprot | |
| K748 | Acetylation | Uniprot | |
| K756 | Acetylation | Uniprot | |
| K756 | Methylation | Uniprot | |
| K756 | Ubiquitination | Uniprot | |
| S759 | Phosphorylation | Uniprot | |
| K770 | Ubiquitination | Uniprot | |
| K781 | Ubiquitination | Uniprot | |
| T850 | Phosphorylation | Uniprot | |
| S855 | Phosphorylation | Uniprot | |
| S856 | Phosphorylation | Uniprot |
研究背景
Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. The NAT activity may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter.
Cleaved by caspases during apoptosis, resulting in a stable 35 kDa fragment.
Cytoplasm. Nucleus.
Note: Mainly cytoplasmic, nuclear in some cases. Present in the free cytosolic and cytoskeleton-bound polysomes, but not in the membrane-bound polysomes.
Expressed at high levels in testis and in ocular endothelial cells. Also found in brain (corpus callosum), heart, colon, bone marrow and at lower levels in most adult tissues, including thyroid, liver, pancreas, mammary and salivary glands, lung, ovary, urogenital system and upper gastrointestinal tract. Overexpressed in gastric cancer, in papillary thyroid carcinomas and in a Burkitt lymphoma cell line (Daudi). Specifically suppressed in abnormal proliferating blood vessels in eyes of patients with proliferative diabetic retinopathy.
Component of the N-terminal acetyltransferase A (NatA) complex composed of NAA10 or probably NAA11 and NAA15. Interacts with XRCC6, NAA50 and XRCC5. Associates with HYPK when in a complex with NAA10. Interaction with HYPK reduces the capacity to interact with NAA50.
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