CHRNA5 Antibody - #DF6586
| 製品: | CHRNA5 Antibody |
| カタログ: | DF6586 |
| タンパク質の説明: | Rabbit polyclonal antibody to CHRNA5 |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| 分子量: | 53kDa; 53kD(Calculated). |
| ユニプロット: | P30532 |
| RRID: | AB_2838548 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF6586, RRID:AB_2838548.
折りたたみ／展開
Acetylcholine receptor nicotinic alpha 5 (neuronal); ACHA5_HUMAN; AChR; Cholinergic receptor neuronal nicotinic alpha polypeptide 5; Cholinergic receptor nicotinic alpha 5; Cholinergic receptor nicotinic alpha polypeptide 5; CHRNA 5; CHRNA5; LNCR2; NACHRA 5; NACHRA5; Neuronal acetylcholine receptor subunit alpha 5; Neuronal acetylcholine receptor subunit alpha-5; Neuronal nicotinic acetylcholine receptor alpha 5 subunit; Neuronal nicotinic acetylcholine receptor, alpha5 subunit; OTTHUMP00000185019;
免疫原
- P30532 ACHA5_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAARGSGPRALRLLLLVQLVAGRCGLAGAAGGAQRGLSEPSSIAKHEDSLLKDLFQDYERWVRPVEHLNDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQEWIDVKLRWNPDDYGGIKVIRVPSDSVWTPDIVLFDNADGRFEGTSTKTVIRYNGTVTWTPPANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIILEDQDVDKRDFFDNGEWEIVSATGSKGNRTDSCCWYPYVTYSFVIKRLPLFYTLFLIIPCIGLSFLTVLVFYLPSNEGEKICLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHHRSSSTHNAMAPLVRKIFLHTLPKLLCMRSHVDRYFTQKEETESGSGPKSSRNTLEAALDSIRYITRHIMKENDVREVVEDWKFIAQVLDRMFLWTFLFVSIVGSLGLFVPVIYKWANILIPVHIGNANK
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P30532 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K45 | Ubiquitination | Uniprot | |
| K52 | Ubiquitination | Uniprot | |
| K71 | Ubiquitination | Uniprot | |
| K100 | Ubiquitination | Uniprot | |
| K107 | Ubiquitination | Uniprot | |
| K119 | Ubiquitination | Uniprot | |
| S147 | Phosphorylation | Uniprot | |
| T148 | Phosphorylation | Uniprot | |
| K149 | Ubiquitination | Uniprot | |
| T150 | Phosphorylation | Uniprot | |
| K227 | Ubiquitination | Uniprot | |
| K354 | Ubiquitination | Uniprot | |
| Y373 | Phosphorylation | Uniprot | |
| K377 | Ubiquitination | Uniprot | |
| K387 | Ubiquitination | Uniprot | |
| K409 | Ubiquitination | Uniprot |
研究背景
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Cell junction>Synapse>Postsynaptic cell membrane>Multi-pass membrane protein. Cell membrane>Multi-pass membrane protein.
Neuronal AChR seems to be composed of two different type of subunits: alpha and non-alpha (beta). Interacts with LYPD6.
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-5/CHRNA5 sub-subfamily.
研究領域
· Environmental Information Processing > Signaling molecules and interaction > Neuroactive ligand-receptor interaction.
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