DCK Antibody - #DF6620
| 製品: | DCK Antibody |
| カタログ: | DF6620 |
| タンパク質の説明: | Rabbit polyclonal antibody to DCK |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| 分子量: | 31kDa; 31kD(Calculated). |
| ユニプロット: | P27707 |
| RRID: | AB_2838582 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF6620, RRID:AB_2838582.
折りたたみ／展開
dCK; DCK protein; DCK_HUMAN; Deoxycytidine kinase; Deoxynucleoside kinase; EC 2.7.1; EC 2.7.1.74; MGC117410; MGC138632; OTTHUMP00000219118; OTTHUMP00000219119;
免疫原
- P27707 DCK_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MATPPKRSCPSFSASSEGTRIKKISIEGNIAAGKSTFVNILKQLCEDWEVVPEPVARWCNVQSTQDEFEELTMSQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAEKPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQATPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNEDFKDKYESLVEKVKEFLSTL
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P27707 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T3 | Phosphorylation | Uniprot | |
| S8 | Phosphorylation | Uniprot | |
| C9 | S-Nitrosylation | Uniprot | |
| S11 | Phosphorylation | P48730 (CSNK1D) | Uniprot |
| S13 | Phosphorylation | Uniprot | |
| S15 | Phosphorylation | P48730 (CSNK1D) | Uniprot |
| S16 | Phosphorylation | Uniprot | |
| T19 | Phosphorylation | Uniprot | |
| K23 | Ubiquitination | Uniprot | |
| K34 | Ubiquitination | Uniprot | |
| S35 | Phosphorylation | Uniprot | |
| K42 | Ubiquitination | Uniprot | |
| S63 | Phosphorylation | Uniprot | |
| T64 | Phosphorylation | Uniprot | |
| T72 | Phosphorylation | P48730 (CSNK1D) | Uniprot |
| S74 | Phosphorylation | Q13535 (ATR) , P48730 (CSNK1D) , Q13315 (ATM) | Uniprot |
| K76 | Ubiquitination | Uniprot | |
| K88 | Acetylation | Uniprot | |
| K88 | Ubiquitination | Uniprot | |
| K115 | Ubiquitination | Uniprot | |
| K117 | Ubiquitination | Uniprot | |
| K121 | Ubiquitination | Uniprot | |
| Y190 | Phosphorylation | Uniprot | |
| Y204 | Phosphorylation | Uniprot | |
| K211 | Ubiquitination | Uniprot | |
| K222 | Ubiquitination | Uniprot | |
| K243 | Ubiquitination | Uniprot | |
| K245 | Ubiquitination | Uniprot | |
| K252 | Acetylation | Uniprot | |
| K252 | Ubiquitination | Uniprot | |
| K254 | Ubiquitination | Uniprot |
研究背景
Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.
Phosphorylated and activated in vitro upon phosphorylation at Ser-74 by CSNK1D/CK1.
Nucleus.
Homodimer.
Belongs to the DCK/DGK family.
研究領域
· Metabolism > Nucleotide metabolism > Purine metabolism.
· Metabolism > Nucleotide metabolism > Pyrimidine metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
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