RGS2 Antibody - #DF6621
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF6621, RRID:AB_2838583.
折りたたみ／展開
Basic helix-loop-helix phosphoprotein G0S8; Cell growth inhibiting protein 31; Cell growth-inhibiting gene 31 protein; G0 to G1 switch regulatory 8 24kD; G0/G1 switch regulatory protein 8; G0S8; GOS8; OTTHUMP00000060765; Regulator of G protein signaling 2; Regulator of G protein signalling 2 24kD; Regulator of G-protein signaling 2; Regulators of G protein signaling XRGSVI; RGS 2; RGS2; RGS2_HUMAN;
免疫原
Expressed in acute myelogenous leukemia (AML) and in acute lymphoblastic leukemia (ALL).
- P41220 RGS2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MQSAMFLAVQHDCRPMDKSAGSGHKSEEKREKMKRTLLKDWKTRLSYFLQNSSTPGKPKTGKKSKQQAFIKPSPEEAQLWSEAFDELLASKYGLAAFRAFLKSEFCEENIEFWLACEDFKKTKSPQKLSSKARKIYTDFIEKEAPKEINIDFQTKTLIAQNIQEATSGCFTTAQKRVYSLMENNSYPRFLESEFYQDLCKKPQITTEPHAT
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P41220 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K39 | Ubiquitination | Uniprot | |
| S46 | Phosphorylation | Q13976 (PRKG1) | Uniprot |
| T54 | Phosphorylation | Uniprot | |
| K57 | Ubiquitination | Uniprot | |
| S64 | Phosphorylation | Q13976 (PRKG1) | Uniprot |
| K71 | Ubiquitination | Uniprot | |
| K121 | Acetylation | Uniprot | |
| K123 | Acetylation | Uniprot | |
| K127 | Ubiquitination | Uniprot | |
| K134 | Ubiquitination | Uniprot | |
| K142 | Ubiquitination | Uniprot | |
| K146 | Ubiquitination | Uniprot | |
| K175 | Ubiquitination | Uniprot | |
| Y178 | Phosphorylation | Uniprot | |
| S179 | Phosphorylation | Uniprot | |
| K201 | Ubiquitination | Uniprot |
研究背景
Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. It is involved in the negative regulation of the angiotensin-activated signaling pathway. Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein.
Phosphorylated by protein kinase C. Phosphorylation by PRKG1 leads to activation of RGS2 activity.
Cell membrane. Cytoplasm. Nucleus>Nucleolus.
Cell membrane. Cytoplasm. Nucleus>Nucleolus.
Cell membrane. Cytoplasm. Nucleus>Nucleolus.
Cell membrane. Mitochondrion.
Expressed in acute myelogenous leukemia (AML) and in acute lymphoblastic leukemia (ALL).
Interacts with GNAQ. Does not interact with GNAI1 and GNAI3. Interacts with EIF2B5. Interacts with PRKG1 (isoform alpha).
研究領域
· Environmental Information Processing > Signal transduction > cGMP-PKG signaling pathway. (View pathway)
· Organismal Systems > Sensory system > Olfactory transduction.
· Organismal Systems > Endocrine system > Oxytocin signaling pathway.
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