THPO Antibody - #DF6640
| 製品: | THPO Antibody |
| カタログ: | DF6640 |
| タンパク質の説明: | Rabbit polyclonal antibody to THPO |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Horse, Sheep |
| 分子量: | 38kDa; 38kD(Calculated). |
| ユニプロット: | P40225 |
| RRID: | AB_2838602 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF6640, RRID:AB_2838602.
折りたたみ／展開
C mpl ligand; C-mpl ligand; Megakaryocyte colony stimulating factor; Megakaryocyte colony-stimulating factor; Megakaryocyte growth and development factor; Megakaryocyte stimulating factor; MGC163194; MGDF; MKCSF; ML; MPL ligand; MPLLG; Myeloproliferative leukemia virus oncogene ligand; Prepro thrombopoietin; THCYT1; THPO; Thrombopoietin; Thrombopoietin nirs variant 1; TPO; TPO_HUMAN;
免疫原
- P40225 TPO_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MELTELLLVVMLLLTARLTLSSPAPPACDLRVLSKLLRDSHVLHSRLSQCPEVHPLPTPVLLPAVDFSLGEWKTQMEETKAQDILGAVTLLLEGVMAARGQLGPTCLSSLLGQLSGQVRLLLGALQSLLGTQLPPQGRTTAHKDPNAIFLSFQHLLRGKVRFLMLVGGSTLCVRRAPPTTAVPSRTSLVLTLNELPNRTSGLLETNFTASARTTGSGLLKWQQGFRAKIPGLLNQTSRSLDQIPGYLNRIHELLNGTRGLFPGPSRRTLGAPDISSGTSDTGSLPPNLQPGYSPSPTHPPTGQYTLFPLPPTLPTPVVQLHPLLPDPSAPTPTPTSPLLNTSYTHSQNLSQEG
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P40225 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S22 | O-Glycosylation | Uniprot | |
| S34 | Phosphorylation | Uniprot | |
| T58 | O-Glycosylation | Uniprot | |
| T58 | Phosphorylation | Uniprot | |
| S68 | Phosphorylation | Uniprot | |
| T79 | Phosphorylation | Uniprot | |
| T131 | O-Glycosylation | Uniprot | |
| T179 | O-Glycosylation | Uniprot | |
| T180 | O-Glycosylation | Uniprot | |
| S184 | O-Glycosylation | Uniprot | |
| N197 | N-Glycosylation | Uniprot | |
| T205 | Phosphorylation | Uniprot | |
| N206 | N-Glycosylation | Uniprot | |
| T213 | O-Glycosylation | Uniprot | |
| S216 | Phosphorylation | Uniprot | |
| N234 | N-Glycosylation | Uniprot | |
| N255 | N-Glycosylation | Uniprot | |
| S265 | O-Glycosylation | Uniprot |
研究背景
Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.
Secreted.
Two-domain structure with an erythropoietin-like N-terminal and a Ser/Pro/Thr-rich C-terminal.
Belongs to the EPO/TPO family.
研究領域
· Environmental Information Processing > Signaling molecules and interaction > Cytokine-cytokine receptor interaction. (View pathway)
· Environmental Information Processing > Signal transduction > Jak-STAT signaling pathway. (View pathway)
· Organismal Systems > Immune system > Hematopoietic cell lineage. (View pathway)
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