IL2RG Antibody - #DF6642
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| 製品: | IL2RG Antibody |
| カタログ: | DF6642 |
| タンパク質の説明: | Rabbit polyclonal antibody to IL2RG |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Sheep, Dog |
| 分子量: | 42kDa; 42kD(Calculated). |
| ユニプロット: | P31785 |
| RRID: | AB_2838604 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF6642, RRID:AB_2838604.
折りたたみ／展開
CD132; CD132 antigen; CIDX; common cytokine receptor gamma chain; Cytokine receptor common subunit gamma; Gamma C; gamma(c); gammaC; IL-2 receptor subunit gamma; IL-2R gamma chain; IL-2R subunit gamma; IL-2RG; Il2rg; IL2RG_HUMAN; IMD4; interleukin 2 receptor, gamma; Interleukin-2 receptor subunit gamma; p64; SCIDX; SCIDX1;
免疫原
- P31785 IL2RG_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLKPSLPFTSLLFLQLPLLGVGLNTTILTPNGNEDTTADFFLTTMPTDSLSVSTLPLPEVQCFVFNVEYMNCTWNSSSEPQPTNLTLHYWYKNSDNDKVQKCSHYLFSEEITSGCQLQKKEIHLYQTFVVQLQDPREPRRQATQMLKLQNLVIPWAPENLTLHKLSESQLELNWNNRFLNHCLEHLVQYRTDWDHSWTEQSVDYRHKFSLPSVDGQKRYTFRVRSRFNPLCGSAQHWSEWSHPIHWGSNTSKENPFLFALEAVVISVGSMGLIISLLCVYFWLERTMPRIPTLKNLEDLVTEYHGNFSAWSGVSKGLAESLQPDYSERLCLVSEIPPKGGALGEGPGASPCNQHSPYWAPPCYTLKPET
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P31785 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| N71 | N-Glycosylation | Uniprot | |
| N84 | N-Glycosylation | Uniprot | |
| K101 | Ubiquitination | Uniprot | |
| K119 | Ubiquitination | Uniprot | |
| K147 | Ubiquitination | Uniprot | |
| N159 | N-Glycosylation | Uniprot | |
| K164 | Ubiquitination | Uniprot | |
| K207 | Ubiquitination | Uniprot | |
| K217 | Ubiquitination | Uniprot | |
| T292 | Phosphorylation | Uniprot | |
| K294 | Ubiquitination | Uniprot | |
| T301 | Phosphorylation | Uniprot | |
| Y303 | Phosphorylation | Uniprot | |
| S308 | Phosphorylation | Uniprot | |
| K315 | Ubiquitination | Uniprot | |
| S320 | Phosphorylation | Uniprot | |
| Y325 | Phosphorylation | Uniprot | |
| S326 | Phosphorylation | Uniprot | |
| Y357 | Phosphorylation | Uniprot | |
| Y363 | Phosphorylation | Uniprot |
研究背景
Common subunit for the receptors for a variety of interleukins. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15.
Cell membrane>Single-pass type I membrane protein. Cell surface.
The gamma subunit is common to the IL2, IL4, IL7, IL15, IL21 and probably also the IL13 receptors. Interacts with SHB upon interleukin stimulation.
(Microbial infection) Interacts with HTLV-1 accessory protein p12I.
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.
Belongs to the type I cytokine receptor family. Type 5 subfamily.
研究領域
· Cellular Processes > Transport and catabolism > Endocytosis. (View pathway)
· Environmental Information Processing > Signaling molecules and interaction > Cytokine-cytokine receptor interaction. (View pathway)
· Environmental Information Processing > Signal transduction > PI3K-Akt signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > Jak-STAT signaling pathway. (View pathway)
· Human Diseases > Infectious diseases: Viral > Measles.
· Human Diseases > Infectious diseases: Viral > HTLV-I infection.
· Human Diseases > Cancers: Overview > Pathways in cancer. (View pathway)
· Human Diseases > Immune diseases > Inflammatory bowel disease (IBD).
· Human Diseases > Immune diseases > Primary immunodeficiency.
· Organismal Systems > Immune system > Th1 and Th2 cell differentiation. (View pathway)
· Organismal Systems > Immune system > Th17 cell differentiation. (View pathway)
参考文献
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