CES1 Antibody - #DF6661
| 製品: | CES1 Antibody |
| カタログ: | DF6661 |
| タンパク質の説明: | Rabbit polyclonal antibody to CES1 |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Dog |
| 分子量: | 63kDa; 63kD(Calculated). |
| ユニプロット: | P23141 |
| RRID: | AB_2838623 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF6661, RRID:AB_2838623.
折りたたみ／展開
ACAT; Acyl coenzyme A cholesterol acyltransferase; Acyl-coenzyme A:cholesterol acyltransferase; Brain carboxylesterase hBr1; Carboxyesterase ES-3; Carboxylesterase; Carboxylesterase 1 (monocyte/macrophage serine esterase 1); Carboxylesterase 1; Carboxylesterase 1 deficiency, included; Carboxylesterase 2, formerly; CE 1; CEH; Ces-1; CES1; CES2; CESDD1; Cholesterol ester hydrolase, neutral, macrophage-derived; Cholesteryl ester hydrolase; Cocaine carboxylesterase; EC 3.1.1.1; Egasyn; ES-HTEL; ES-x; Es22; EST1_HUMAN; Esterase 22; Esterase; hCE 1; HMSE; HMSE1; Liver carboxylesterase 1; Liver carboxylesterase 3; Methylumbelliferyl acetate deacetylase 1; MGC117365; MGC156521; Monocyte carboxylesterase deficiency, included; Monocyte esterase deficiency, included; Monocyte/macrophage serine esterase; PCE-1; pI 5.5 esterase; Proline-beta-naphthylamidase; REH; Retinyl ester hydrolase; Serine esterase 1; Ses-1; SES1; TGH; Triacylglycerol hydrolase;
免疫原
- P23141 EST1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MWLRAFILATLSASAAWGHPSSPPVVDTVHGKVLGKFVSLEGFAQPVAIFLGIPFAKPPLGPLRFTPPQPAEPWSFVKNATSYPPMCTQDPKAGQLLSELFTNRKENIPLKLSEDCLYLNIYTPADLTKKNRLPVMVWIHGGGLMVGAASTYDGLALAAHENVVVVTIQYRLGIWGFFSTGDEHSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLFHRAISESGVALTSVLVKKGDVKPLAEQIAITAGCKTTTSAVMVHCLRQKTEEELLETTLKMKFLSLDLQGDPRESQPLLGTVIDGMLLLKTPEELQAERNFHTVPYMVGINKQEFGWLIPMQLMSYPLSEGQLDQKTAMSLLWKSYPLVCIAKELIPEATEKYLGGTDDTVKKKDLFLDLIADVMFGVPSVIVARNHRDAGAPTYMYEFQYRPSFSSDMKPKTVIGDHGDELFSVFGAPFLKEGASEEEIRLSKMVMKFWANFARNGNPNGEGLPHWPEYNQKEGYLQIGANTQAAQKLKDKEVAFWTNLFAKKAVEKPPQTEHIEL
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P23141 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| N79 | N-Glycosylation | Uniprot | |
| Y83 | Phosphorylation | Uniprot | |
| T88 | Phosphorylation | Uniprot | |
| S380 | Phosphorylation | Uniprot | |
| K393 | Ubiquitination | Uniprot | |
| K402 | Acetylation | Uniprot | |
| K402 | Ubiquitination | Uniprot | |
| Y403 | Phosphorylation | Uniprot | |
| T407 | Phosphorylation | Uniprot | |
| T444 | Phosphorylation | Uniprot | |
| S493 | Phosphorylation | Uniprot | |
| K538 | Acetylation | Uniprot | |
| K558 | Acetylation | Uniprot |
研究背景
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine. Catalyzes the transesterification of cocaine to form cocaethylene. Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate.
Contains sialic acid.
Cleavage of the signal sequence can occur at 2 positions, either between Trp-17 and Gly-18 or between Gly-18 and His-19.
Endoplasmic reticulum lumen.
Expressed predominantly in liver with lower levels in heart and lung.
Homotrimer and homohexamer. Binds to beta-glucuronidase.
Belongs to the type-B carboxylesterase/lipase family.
研究領域
· Metabolism > Xenobiotics biodegradation and metabolism > Drug metabolism - other enzymes.
· Metabolism > Global and overview maps > Metabolic pathways.
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