GLB1 Antibody - #DF6667
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製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF6667, RRID:AB_2838629.
折りたたみ／展開
Acid beta galactosidase; Acid beta-galactosidase; Beta galactosidase 1; Beta galactosidase; Beta-galactosidase; BGAL_HUMAN; EBP; EBP, included; Elastin receptor 1 (67kD); Elastin receptor 1 67kDa; Elastin receptor 1; Elastin receptor 1, included; Elastin-binding protein, included; ELNR1; Galactosidase beta 1; GLB 1; GLB1; Lactase; MPS4B; S-GAL, included;
免疫原
Detected in placenta (at protein level) (PubMed:8383699). Detected in fibroblasts and testis (PubMed:2511208).
- P16278 BGAL_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPGFLVRILPLLLVLLLLGPTRGLRNATQRMFEIDYSRDSFLKDGQPFRYISGSIHYSRVPRFYWKDRLLKMKMAGLNAIQTYVPWNFHEPWPGQYQFSEDHDVEYFLRLAHELGLLVILRPGPYICAEWEMGGLPAWLLEKESILLRSSDPDYLAAVDKWLGVLLPKMKPLLYQNGGPVITVQVENEYGSYFACDFDYLRFLQKRFRHHLGDDVVLFTTDGAHKTFLKCGALQGLYTTVDFGTGSNITDAFLSQRKCEPKGPLINSEFYTGWLDHWGQPHSTIKTEAVASSLYDILARGASVNLYMFIGGTNFAYWNGANSPYAAQPTSYDYDAPLSEAGDLTEKYFALRNIIQKFEKVPEGPIPPSTPKFAYGKVTLEKLKTVGAALDILCPSGPIKSLYPLTFIQVKQHYGFVLYRTTLPQDCSNPAPLSSPLNGVHDRAYVAVDGIPQGVLERNNVITLNITGKAGATLDLLVENMGRVNYGAYINDFKGLVSNLTLSSNILTDWTIFPLDTEDAVRSHLGGWGHRDSGHHDEAWAHNSSNYTLPAFYMGNFSIPSGIPDLPQDTFIQFPGWTKGQVWINGFNLGRYWPARGPQLTLFVPQHILMTSAPNTITVLELEWAPCSSDDPELCAVTFVDRPVIGSSVTYDHPSKPVEKRLMPPPPQKNKDSWLDHV
PTMs - P16278 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T21 | Phosphorylation | Uniprot | |
| S37 | Phosphorylation | Uniprot | |
| S40 | Phosphorylation | Uniprot | |
| K43 | Methylation | Uniprot | |
| K43 | Ubiquitination | Uniprot | |
| Y57 | Phosphorylation | Uniprot | |
| S58 | Phosphorylation | Uniprot | |
| Y154 | Phosphorylation | Uniprot | |
| N247 | N-Glycosylation | Uniprot | |
| T286 | Phosphorylation | Uniprot | |
| Y294 | Phosphorylation | Uniprot | |
| S368 | Phosphorylation | Uniprot | |
| T369 | Phosphorylation | Uniprot | |
| K383 | Ubiquitination | Uniprot | |
| N464 | N-Glycosylation | Uniprot | |
| Y485 | Phosphorylation | Uniprot | |
| Y488 | Phosphorylation | Uniprot | |
| K493 | Acetylation | Uniprot | |
| N498 | N-Glycosylation | Uniprot | |
| N555 | N-Glycosylation | Uniprot | |
| K670 | Ubiquitination | Uniprot |
研究背景
Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.
Has no beta-galactosidase catalytic activity, but plays functional roles in the formation of extracellular elastic fibers (elastogenesis) and in the development of connective tissue. Seems to be identical to the elastin-binding protein (EBP), a major component of the non-integrin cell surface receptor expressed on fibroblasts, smooth muscle cells, chondroblasts, leukocytes, and certain cancer cell types. In elastin producing cells, associates with tropoelastin intracellularly and functions as a recycling molecular chaperone which facilitates the secretions of tropoelastin and its assembly into elastic fibers.
Lysosome.
Cytoplasm>Perinuclear region.
Note: Localized to the perinuclear area of the cytoplasm but not to lysosomes.
Detected in placenta (at protein level). Detected in fibroblasts and testis.
Homodimer. May form higher multimers (Probable).
Belongs to the glycosyl hydrolase 35 family.
研究領域
· Cellular Processes > Transport and catabolism > Lysosome. (View pathway)
· Metabolism > Carbohydrate metabolism > Galactose metabolism.
· Metabolism > Glycan biosynthesis and metabolism > Other glycan degradation.
· Metabolism > Glycan biosynthesis and metabolism > Glycosaminoglycan degradation.
· Metabolism > Lipid metabolism > Sphingolipid metabolism.
· Metabolism > Glycan biosynthesis and metabolism > Glycosphingolipid biosynthesis - ganglio series.
· Metabolism > Global and overview maps > Metabolic pathways.
参考文献
Application: IHC Species: Mouse Sample:
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