IL24 Antibody - #DF6672

(2)  
製品: IL24 Antibody
カタログ: DF6672
タンパク質の説明: Rabbit polyclonal antibody to IL24
アプリケーション: WB IHC
反応性: Human, Mouse, Rat
分子量: 24kDa; 24kD(Calculated).
ユニプロット: Q13007
RRID: AB_2838634

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MS Report
HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
クローナリティ:
Polyclonal
特異性:
IL24 Antibody detects endogenous levels of total IL24.
RRID:
AB_2838634
引用形式: Affinity Biosciences Cat# DF6672, RRID:AB_2838634.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

C49A; FISP; IL 24; IL 4 induced secreted protein; IL-24; IL10B; Il24; IL24_HUMAN; interleukin 24; Interleukin-24; MDA-7; MDA7; Melanocyte associated Mda 7; Melanoma differentiation association protein 7; Melanoma differentiation-associated gene 7 protein; Mob5; ST16; Suppression of tumorigenicity 16 (melanoma differentiation); Suppression of tumorigenicity 16; Suppression of tumorigenicity 16 protein;

免疫原

免疫原:
Uniprot:

Q13007(IL24_HUMAN) >>Visit HPA database.

遺伝子(ID):
IL24(11009)
発現特異性:
Q13007 IL24_HUMAN:

Up-regulated in melanoma cells induced to terminally differentiate.

タンパク質の説明:
This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
タンパク質配列:
MNFQQRLQSLWTLARPFCPPLLATASQMQMVVLPCLGFTLLLWSQVSGAQGQEFHFGPCQVKGVVPQKLWEAFWAVKDTMQAQDNITSARLLQQEVLQNVSDAESCYLVHTLLEFYLKTVFKNYHNRTVEVRTLKSFSTLANNFVLIVSQLQPSQENEMFSIRDSAHRRFLLFRRAFKQLDVEAALTKALGEVDILLTWMQKFYKL

PTMs - Q13007 基板として

Site PTM Type Enzyme
S88 Phosphorylation
S101 Phosphorylation
T111 Phosphorylation
K122 Ubiquitination
T133 Phosphorylation
S161 Phosphorylation
T198 Phosphorylation

研究背景

機能:

Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation.

PTMs:

Ubiquitination at Lys-122 promotes proteasomal degradation.

細胞の位置付け:

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Up-regulated in melanoma cells induced to terminally differentiate.

タンパク質ファミリー:

Belongs to the IL-10 family.

研究領域

· Environmental Information Processing > Signaling molecules and interaction > Cytokine-cytokine receptor interaction.   (View pathway)

· Environmental Information Processing > Signal transduction > Jak-STAT signaling pathway.   (View pathway)

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