CCL21 Antibody - #DF6681
製品: | CCL21 Antibody |
カタログ: | DF6681 |
タンパク質の説明: | Rabbit polyclonal antibody to CCL21 |
アプリケーション: | WB IHC |
反応性: | Human, Mouse, Rat |
分子量: | 15kDa; 15kD(Calculated). |
ユニプロット: | O00585 |
RRID: | AB_2838643 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF6681, RRID:AB_2838643.
折りたたみ/展開
6Ckine; Beta-chemokine exodus-2; C C motif chemokine ligand 21; C-C motif chemokine 21; CCL21; CCL21_HUMAN; Chemokine (C-C motif) ligand 21; Chemokine CC motif ligand 21; CKb9; ECL; Efficient Chemoattractant for Lymphocytes; SCYA21; Secondary lymphoid-tissue chemokine; SLC; Small inducible cytokine A21; Small inducible cytokine subfamily A (Cys-Cys), member 21; Small-inducible cytokine A21; TCA4; UNQ784/PRO1600;
免疫原
Highly expressed in high endothelial venules of lymph nodes, spleen and appendix. Intermediate levels found in small intestine, thyroid gland and trachea. Low level expression in thymus, bone marrow, liver, and pancreas. Also found in tonsil, fetal heart and fetal spleen.
- O00585 CCL21_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAQSLALSLLILVLAFGIPRTQGSDGGAQDCCLKYSQRKIPAKVVRSYRKQEPSLGCSIPAILFLPRKRSQAELCADPKELWVQQLMQHLDKTPSPQKPAQGCRKDRGASKTGKKGKGSKGCKRTERSQTPKGP
PTMs - O00585 基板として
Site | PTM Type | Enzyme | Source |
---|---|---|---|
K114 | Acetylation | Uniprot | |
K115 | Acetylation | Uniprot | |
K115 | Methylation | Uniprot | |
K117 | Acetylation | Uniprot | |
K117 | Methylation | Uniprot | |
K120 | Acetylation | Uniprot | |
K120 | Methylation | Uniprot | |
K123 | Methylation | Uniprot |
研究背景
Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.
Secreted.
Highly expressed in high endothelial venules of lymph nodes, spleen and appendix. Intermediate levels found in small intestine, thyroid gland and trachea. Low level expression in thymus, bone marrow, liver, and pancreas. Also found in tonsil, fetal heart and fetal spleen.
Monomer. Binds to CCR7. Interacts with PDPN; relocalizes PDPN to the basolateral membrane.
Belongs to the intercrine beta (chemokine CC) family.
研究領域
· Environmental Information Processing > Signaling molecules and interaction > Cytokine-cytokine receptor interaction. (View pathway)
· Environmental Information Processing > Signal transduction > NF-kappa B signaling pathway. (View pathway)
· Organismal Systems > Immune system > Chemokine signaling pathway. (View pathway)
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