製品: TBXAS1 Antibody
カタログ: DF6739
タンパク質の説明: Rabbit polyclonal antibody to TBXAS1
アプリケーション: WB IHC IF/ICC
反応性: Human, Mouse, Rat
予測: Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
分子量: 61kDa; 61kD(Calculated).
ユニプロット: P24557
RRID: AB_2838701

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 100ul $280 在庫あり
 200ul $350 在庫あり

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製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
予測:
Pig(82%), Bovine(82%), Horse(91%), Sheep(82%), Rabbit(100%), Dog(100%), Chicken(86%)
クローナリティ:
Polyclonal
特異性:
TBXAS1 Antibody detects endogenous levels of total TBXAS1.
RRID:
AB_2838701
引用形式: Affinity Biosciences Cat# DF6739, RRID:AB_2838701.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ/展開

BDPLT14; CYP5; CYP5A1; Cytochrome P450 5A1; Cytochrome P450, family 5, subfamily A, polypeptide 1; FLJ52771; GHOSAL; Platelet cytochrome P450 subfamily V; Tbxas1; THAS; THAS_HUMAN; Thromboxane A synthase 1 (platelet); Thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A); Thromboxane A synthase 1; Thromboxane A synthase 1 platelet cytochrome P450 subfamily V; Thromboxane-A synthase; TS; TXA synthase; TXAS; TXS;

免疫原

免疫原:
Uniprot:
遺伝子(ID):
発現特異性:
P24557 THAS_HUMAN:

Platelets, lung, kidney, spleen, macrophages and lung fibroblasts.

タンパク質の説明:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
タンパク質配列:
MEALGFLKLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGFWESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Rabbit
100
Dog
100
Horse
91
Chicken
86
Pig
82
Bovine
82
Sheep
82
Xenopus
73
Zebrafish
71
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - P24557 基板として

Site PTM Type Enzyme
T57 Phosphorylation

研究背景

細胞の位置付け:

Endoplasmic reticulum membrane>Multi-pass membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Platelets, lung, kidney, spleen, macrophages and lung fibroblasts.

サブユニット構造:

Monomer.

タンパク質ファミリー:

Belongs to the cytochrome P450 family.

研究領域

· Metabolism > Lipid metabolism > Arachidonic acid metabolism.

· Metabolism > Global and overview maps > Metabolic pathways.

· Organismal Systems > Immune system > Platelet activation.   (View pathway)

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