RPS19 Antibody - #DF6756

(1)  
製品: RPS19 Antibody
カタログ: DF6756
タンパク質の説明: Rabbit polyclonal antibody to RPS19
アプリケーション: WB IHC IF/ICC
反応性: Human, Mouse, Rat
予測: Pig, Bovine, Horse, Sheep, Dog
分子量: 16kDa; 16kD(Calculated).
ユニプロット: P39019
RRID: AB_2838718

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MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
予測:
Pig(100%), Bovine(100%), Horse(100%), Sheep(100%), Dog(100%)
クローナリティ:
Polyclonal
特異性:
RPS19 Antibody detects endogenous levels of total RPS19.
RRID:
AB_2838718
引用形式: Affinity Biosciences Cat# DF6756, RRID:AB_2838718.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

40S ribosomal protein S19; DBA; DBA1; HGNC:10402; Ribosomal protein S19; rps19; RS19_HUMAN; S19;

免疫原

免疫原:
Uniprot:

P39019(RS19_HUMAN) >>Visit HPA database.

遺伝子(ID):
RPS19(6223)
発現特異性:
P39019 RS19_HUMAN:

Higher level expression is seen in the colon carcinoma tissue than normal colon tissue.

タンパク質の説明:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19E family of ribosomal proteins. It is located in the cytoplasm. Mutations in this gene cause Diamond-Blackfan anemia (DBA), a constitutional erythroblastopenia characterized by absent or decreased erythroid precursors, in a subset of patients. This suggests a possible extra-ribosomal function for this gene in erythropoietic differentiation and proliferation, in addition to its ribosomal function. Higher expression levels of this gene in some primary colon carcinomas compared to matched normal colon tissues has been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
タンパク質配列:
MPGVTVKDVNQQEFVRALAAFLKKSGKLKVPEWVDTVKLAKHKELAPYDENWFYTRAASTARHLYLRGGAGVGSMTKIYGGRQRNGVMPSHFSRGSKSVARRVLQALEGLKMVEKDQDGGRKLTPQGQRDLDRIAGQVAAANKKH

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Xenopus
0
Zebrafish
0
Chicken
0
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - P39019 基板として

Site PTM Type Enzyme
K7 Ubiquitination
K23 Acetylation
K29 Ubiquitination
K38 Ubiquitination
K43 Ubiquitination
Y48 Phosphorylation
Y54 Phosphorylation
T55 Phosphorylation
R56 Methylation
S59 Phosphorylation P17612 (PRKACA) , Q14012 (CAMK1)
R67 Methylation
S74 Phosphorylation
T76 Phosphorylation
K77 Acetylation
K77 Ubiquitination
R94 Methylation
K111 Acetylation
K111 Ubiquitination
K115 Acetylation
K122 Ubiquitination
R133 Methylation
K143 Acetylation
K143 Ubiquitination
K144 Acetylation

研究背景

機能:

Required for pre-rRNA processing and maturation of 40S ribosomal subunits.

細胞の位置付け:

Nucleus.
Note: Located more specifically in the nucleoli.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Higher level expression is seen in the colon carcinoma tissue than normal colon tissue.

サブユニット構造:

Interacts with RPS19BP1.

タンパク質ファミリー:

Belongs to the eukaryotic ribosomal protein eS19 family.

研究領域

· Genetic Information Processing > Translation > Ribosome.

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