PVRL1 Antibody - #DF6771
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF6771, RRID:AB_2838733.
折りたたみ／展開
CD111; CD111 antigen; CLPED1; ectodermal dysplasia 4 (Margarita Island type); ED4; Herpes virus entry mediator C; Herpesvirus entry mediator C; Herpesvirus Ig like receptor; Herpesvirus Ig-like receptor; HIgR; HveC; MGC142031; Nectin 1; Nectin-1; OFC7; OROFACIAL CLEFT 7; OTTHUMP00000232093; OTTHUMP00000232094; OTTHUMP00000232095; Poliovirus receptor related protein 1; poliovirus receptor-like 1; Poliovirus receptor-related protein 1; PRR; PRR1; PVRL 1; PVRL1; PVRL1_HUMAN; PVRR; PVRR1; SK-12;
免疫原
- Q15223 NECT1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MARMGLAGAAGRWWGLALGLTAFFLPGVHSQVVQVNDSMYGFIGTDVVLHCSFANPLPSVKITQVTWQKSTNGSKQNVAIYNPSMGVSVLAPYRERVEFLRPSFTDGTIRLSRLELEDEGVYICEFATFPTGNRESQLNLTVMAKPTNWIEGTQAVLRAKKGQDDKVLVATCTSANGKPPSVVSWETRLKGEAEYQEIRNPNGTVTVISRYRLVPSREAHQQSLACIVNYHMDRFKESLTLNVQYEPEVTIEGFDGNWYLQRMDVKLTCKADANPPATEYHWTTLNGSLPKGVEAQNRTLFFKGPINYSLAGTYICEATNPIGTRSGQVEVNITEFPYTPSPPEHGRRAGPVPTAIIGGVAGSILLVLIVVGGIVVALRRRRHTFKGDYSTKKHVYGNGYSKAGIPQHHPPMAQNLQYPDDSDDEKKAGPLGGSSYEEEEEEEEGGGGGERKVGGPHPKYDEDAKRPYFTVDEAEARQDGYGDRTLGYQYDPEQLDLAENMVSQNDGSFISKKEWYV
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q15223 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S52 | Phosphorylation | Uniprot | |
| S59 | Phosphorylation | Uniprot | |
| N72 | N-Glycosylation | Uniprot | |
| N139 | N-Glycosylation | Uniprot | |
| K145 | Ubiquitination | Uniprot | |
| S181 | Phosphorylation | Uniprot | |
| K190 | Ubiquitination | Uniprot | |
| N202 | N-Glycosylation | Uniprot | |
| Y211 | Phosphorylation | Uniprot | |
| N332 | N-Glycosylation | Uniprot | |
| K386 | Ubiquitination | Uniprot | |
| Y389 | Phosphorylation | Uniprot | |
| S390 | Phosphorylation | Uniprot | |
| T391 | Phosphorylation | Uniprot | |
| K393 | Ubiquitination | Uniprot | |
| Y396 | Phosphorylation | Uniprot | |
| Y400 | Phosphorylation | Uniprot | |
| Y418 | Phosphorylation | Uniprot | |
| S422 | Phosphorylation | Uniprot | |
| K427 | Ubiquitination | Uniprot | |
| S434 | Phosphorylation | Uniprot | |
| S435 | Phosphorylation | Uniprot | |
| Y436 | Phosphorylation | Uniprot | |
| Y460 | Phosphorylation | Uniprot | |
| K465 | Ubiquitination | Uniprot | |
| Y468 | Phosphorylation | Uniprot | |
| T470 | Phosphorylation | Uniprot | |
| Y481 | Phosphorylation | Uniprot | |
| Y488 | Phosphorylation | Uniprot | |
| Y490 | Phosphorylation | Uniprot | |
| S508 | Phosphorylation | Uniprot | |
| S511 | Phosphorylation | Uniprot |
研究背景
Promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between NECTIN1 and NECTIN3 and between NECTIN1 and NECTIN4. Has some neurite outgrowth-promoting activity.
(Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1, herpes simplex virus 2/HHV-2, and pseudorabies virus/PRV.
Cell membrane>Single-pass type I membrane protein. Cell junction>Synapse>Presynaptic cell membrane.
Cell membrane>Single-pass type I membrane protein.
Secreted.
Interacts (via Ig-like C2-type domain 2) with FGFR1, FGFR2 and FGFR3 (By similarity). Cis- and trans-homodimer. Can form trans-heterodimers with NECTIN3 and with NECTIN4. Interaction between NECTIN1 and NECTIN3 on the pre- and postsynaptic sites, respectively, initiates the formation of puncta adherentia junctions between axons and dendrites. Interacts (via cytoplasmic domain) with AFDN (via PDZ domain); this interaction recruits NECTIN1 to cadherin-based adherens junctions and provides a connection with the actin cytoskeleton. Interacts with integrin alphaV/beta3.
(Microbial infection) Interacts with herpes simplex virus 1/HHV-1, herpes simplex virus 2/HHV-2, and pseudorabies virus/PRV envelope glycoprotein D.
Ig-like C2-type 2 mediates neurite outgrowth through binding, induction of phosphorylation, and activation of FGFR.
Belongs to the nectin family.
研究領域
· Cellular Processes > Cellular community - eukaryotes > Adherens junction. (View pathway)
· Environmental Information Processing > Signaling molecules and interaction > Cell adhesion molecules (CAMs). (View pathway)
· Human Diseases > Infectious diseases: Viral > Herpes simplex infection.
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