KLRD1 Antibody - #DF6773

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製品: KLRD1 Antibody
カタログ: DF6773
タンパク質の説明: Rabbit polyclonal antibody to KLRD1
アプリケーション: WB IHC IF/ICC
反応性: Human, Mouse, Rat
分子量: 20kDa; 21kD(Calculated).
ユニプロット: Q13241
RRID: AB_2838735

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MS Report
HPLC Report
MSDS
説明書
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プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
クローナリティ:
Polyclonal
特異性:
KLRD1 Antibody detects endogenous levels of total KLRD1.
RRID:
AB_2838735
引用形式: Affinity Biosciences Cat# DF6773, RRID:AB_2838735.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

CD 94; CD94; CD94 antigen; Killer cell lectin like receptor subfamily D member 1; Killer cell lectin-like receptor subfamily D member 1; KLRD 1; KLRD1; KLRD1 protein; KLRD1_HUMAN; KP 43; KP43; Natural killer cells antigen CD94; NK cell receptor; OTTHUMP00000238754; OTTHUMP00000238755; OTTHUMP00000238756; OTTHUMP00000238758; OTTHUMP00000239093;

免疫原

免疫原:
Uniprot:

Q13241(KLRD1_HUMAN) >>Visit HPA database.

遺伝子(ID):
KLRD1(3824)
発現特異性:
Q13241 KLRD1_HUMAN:

Natural killer cells.

タンパク質の説明:
Natural killer (NK) cells are a distinct lineage of lymphocytes that mediate cytotoxic activity and secrete cytokines upon immune stimulation. Several genes of the C-type lectin superfamily, including members of the NKG2 family, are expressed by NK cells and may be involved in the regulation of NK cell function. KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
タンパク質配列:
MAVFKTTLWRLISGTLGIICLSLMSTLGILLKNSFTKLSIEPAFTPGPNIELQKDSDCCSCQEKWVGYRCNCYFISSEQKTWNESRHLCASQKSSLLQLQNTDELDFMSSSQQFYWIGLSYSEEHTAWLWENGSALSQYLFPSFETFNTKNCIAYNPNGNALDESCEDKNRYICKQQLI

PTMs - Q13241 基板として

Site PTM Type Enzyme
S13 Phosphorylation
T15 Phosphorylation
Y73 Phosphorylation

研究背景

機能:

Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.

細胞の位置付け:

Cell membrane>Single-pass type II membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Natural killer cells.

サブユニット構造:

Can form disulfide-bonded heterodimer with NKG2 family members. KLRD1-KLRC1 heterodimer interacts with peptide-bound HLA-E-B2M heterotrimeric complex. KLRD1 plays a prominent role in directly interacting with HLA-E. Interacts with the adapter protein TYROBP/DAP12; the interaction leads to natural killer cell activation.

研究領域

· Human Diseases > Immune diseases > Graft-versus-host disease.

· Organismal Systems > Immune system > Antigen processing and presentation.   (View pathway)

· Organismal Systems > Immune system > Natural killer cell mediated cytotoxicity.   (View pathway)

参考文献

1). Single-cell analysis of gastric signet ring cell carcinoma reveals cytological and immune microenvironment features. Nature Communications, 2023 (PubMed: 37225691) [IF=16.6]

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