CAPZA2 Antibody - #DF6784
| 製品: | CAPZA2 Antibody |
| カタログ: | DF6784 |
| タンパク質の説明: | Rabbit polyclonal antibody to CAPZA2 |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 33kDa; 33kD(Calculated). |
| ユニプロット: | P47755 |
| RRID: | AB_2838746 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF6784, RRID:AB_2838746.
折りたたみ／展開
CAPPA2; Capping protein (actin filament) muscle Z line, alpha 2; CapZ alpha 2; CapZ alpha-2; CAPZ; CAPZA2; CAZA2_HUMAN; F actin capping protein alpha 2 subunit; F actin capping protein subunit alpha 2; F-actin-capping protein subunit alpha-2;
免疫原
- P47755 CAZA2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDVRLLLNNDNLLREGAAHAFAQYNLDQFTPVKIEGYEDQVLITEHGDLGNGKFLDPKNRICFKFDHLRKEATDPRPCEVENAVESWRTSVETALRAYVKEHYPNGVCTVYGKKIDGQQTIIACIESHQFQAKNFWNGRWRSEWKFTITPSTTQVVGILKIQVHYYEDGNVQLVSHKDIQDSLTVSNEVQTAKEFIKIVEAAENEYQTAISENYQTMSDTTFKALRRQLPVTRTKIDWNKILSYKIGKEMQNA
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P47755 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| S9 | Phosphorylation | Uniprot | |
| K13 | Ubiquitination | Uniprot | |
| K19 | Acetylation | Uniprot | |
| K19 | Ubiquitination | Uniprot | |
| T63 | Phosphorylation | Uniprot | |
| K86 | Acetylation | Uniprot | |
| K86 | Ubiquitination | Uniprot | |
| K91 | Ubiquitination | Uniprot | |
| K97 | Acetylation | Uniprot | |
| K97 | Ubiquitination | Uniprot | |
| K103 | Ubiquitination | Uniprot | |
| K133 | Ubiquitination | Uniprot | |
| T142 | Phosphorylation | Uniprot | |
| Y144 | Phosphorylation | Uniprot | |
| K146 | Ubiquitination | Uniprot | |
| T180 | Phosphorylation | Uniprot | |
| Y198 | Phosphorylation | Uniprot | |
| K226 | Ubiquitination | Uniprot | |
| K230 | Ubiquitination | Uniprot | |
| K256 | Methylation | Uniprot | |
| K256 | Ubiquitination | Uniprot | |
| K268 | Sumoylation | Uniprot | |
| K268 | Ubiquitination | Uniprot | |
| K273 | Acetylation | Uniprot | |
| K273 | Sumoylation | Uniprot | |
| K273 | Ubiquitination | Uniprot | |
| Y277 | Phosphorylation | Uniprot | |
| K278 | Acetylation | Uniprot | |
| K278 | Sumoylation | Uniprot | |
| K278 | Ubiquitination | Uniprot | |
| K281 | Ubiquitination | Uniprot |
研究背景
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
Heterodimer of an alpha and a beta subunit. Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH (WASHC1, WASH2P, WASH3P, WASH4P, WASH5P or WASH6P), WASHC2 (WASHC2A or WASHC2C), WASHC3, WASHC4 and WASHC5. Interacts with RCSD1/CAPZIP. Directly interacts with CRACD; this interaction decreases binding to actin.
Belongs to the F-actin-capping protein alpha subunit family.
研究領域
· Cellular Processes > Transport and catabolism > Endocytosis. (View pathway)
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