ETV5 Antibody - #BF0096

(1)  
製品: ETV5 Antibody
カタログ: BF0096
タンパク質の説明: Mouse monoclonal antibody to ETV5
アプリケーション: WB ELISA
反応性: Human
分子量: 58kDa; 58kD(Calculated).
ユニプロット: P41161
RRID: AB_2833818

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MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Mouse
アプリケーション:
ELISA 1:10000, WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human
クローナリティ:
Monoclonal [AFB1794]
特異性:
ETV5 antibody detects endogenous levels of total ETV5.
RRID:
AB_2833818
引用形式: Affinity Biosciences Cat# BF0096, RRID:AB_2833818.
コンジュゲート:
Unconjugated.
精製:
Affinity-chromatography.
保存:
Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

ERM; Ets related protein ERM; ETS translocation variant 5; Ets variant gene 5; Ets-related protein ERM; ETV5; ETV5_HUMAN;

免疫原

免疫原:

Purified recombinant fragment of human ETV5 expressed in E. Coli.

Uniprot:

P41161(ETV5_HUMAN) >>Visit HPA database.

遺伝子(ID):
ETV5(2119)
発現特異性:
P41161 ETV5_HUMAN:

Ubiquitous.

タンパク質の説明:
ETS variant 5,transcription factor of the ETS family,divergent member of the winged helix-turn-helix superfamily,expressed in brain,placenta and other tissues involved in development. Tissue specificity: Ubiquitous. ERM is expressed in Sertoli cells and spermatogonial stem cells (SSCs). Studies on knockout mice have shown that it is required for SSC self-renewal but not differentiation, thus affected mice exhibit progressive germ cell depletion.
タンパク質配列:
MDGFYDQQVPFMVPGKSRSEECRGRPVIDRKRKFLDTDLAHDSEELFQDLSQLQEAWLAEAQVPDDEQFVPDFQSDNLVLHAPPPTKIKRELHSPSSELSSCSHEQALGANYGEKCLYNYCAYDRKPPSGFKPLTPPTTPLSPTHQNPLFPPPQATLPTSGHAPAAGPVQGVGPAPAPHSLPEPGPQQQTFAVPRPPHQPLQMPKMMPENQYPSEQRFQRQLSEPCHPFPPQPGVPGDNRPSYHRQMSEPIVPAAPPPPQGFKQEYHDPLYEHGVPGMPGPPAHGFQSPMGIKQEPRDYCVDSEVPNCQSSYMRGGYFSSSHEGFSYEKDPRLYFDDTCVVPERLEGKVKQEPTMYREGPPYQRRGSLQLWQFLVTLLDDPANAHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPDALFSMAFPDNQRPFLKAESECHLSEEDTLPLTHFEDSPAYLLDMDRCSSLPYAEGFAY

PTMs - P41161 基板として

Site PTM Type Enzyme
Y5 Phosphorylation
K89 Sumoylation
S94 Phosphorylation
S248 Phosphorylation
K263 Sumoylation
K293 Sumoylation
S310 Phosphorylation
K329 Ubiquitination
K350 Sumoylation
S367 Phosphorylation P17612 (PRKACA)
Y443 Phosphorylation
K468 Sumoylation

研究背景

機能:

Binds to DNA sequences containing the consensus nucleotide core sequence 5'-GGAA.-3'.

細胞の位置付け:

Nucleus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Ubiquitous.

サブユニット構造:

Interacts (via C-terminal) with ZMYM5 (via N-terminal 120 amino acid region).

タンパク質ファミリー:

Belongs to the ETS family.

研究領域

· Human Diseases > Cancers: Overview > Transcriptional misregulation in cancer.

· Human Diseases > Cancers: Specific types > Prostate cancer.   (View pathway)

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