Zyxin Antibody - #DF6858
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF6858, RRID:AB_2838817.
折りたたみ／展開
ESP 2; ESP2; HED 2; HED2; ZYX; ZYX protein; Zyxin 2; Zyxin2;
免疫原
- Q15942 ZYX_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAAPRPSPAISVSVSAPAFYAPQKKFGPVVAPKPKVNPFRPGDSEPPPAPGAQRAQMGRVGEIPPPPPEDFPLPPPPLAGDGDDAEGALGGAFPPPPPPIEESFPPAPLEEEIFPSPPPPPEEEGGPEAPIPPPPQPREKVSSIDLEIDSLSSLLDDMTKNDPFKARVSSGYVPPPVATPFSSKSSTKPAAGGTAPLPPWKSPSSSQPLPQVPAPAQSQTQFHVQPQPQPKPQVQLHVQSQTQPVSLANTQPRGPPASSPAPAPKFSPVTPKFTPVASKFSPGAPGGSGSQPNQKLGHPEALSAGTGSPQPPSFTYAQQREKPRVQEKQHPVPPPAQNQNQVRSPGAPGPLTLKEVEELEQLTQQLMQDMEHPQRQNVAVNELCGRCHQPLARAQPAVRALGQLFHIACFTCHQCAQQLQGQQFYSLEGAPYCEGCYTDTLEKCNTCGEPITDRMLRATGKAYHPHCFTCVVCARPLEGTSFIVDQANRPHCVPDYHKQYAPRCSVCSEPIMPEPGRDETVRVVALDKNFHMKCYKCEDCGKPLSIEADDNGCFPLDGHVLCRKCHTARAQT
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q15942 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| R5 | Methylation | Uniprot | |
| S7 | Phosphorylation | Uniprot | |
| S13 | Phosphorylation | Uniprot | |
| S15 | Phosphorylation | Uniprot | |
| Y20 | Phosphorylation | Uniprot | |
| K24 | Acetylation | Uniprot | |
| K25 | Acetylation | Uniprot | |
| K25 | Methylation | Uniprot | |
| S44 | Phosphorylation | Uniprot | |
| S116 | Phosphorylation | Uniprot | |
| S142 | Phosphorylation | P31749 (AKT1) | Uniprot |
| S143 | Phosphorylation | Uniprot | |
| S150 | Phosphorylation | Uniprot | |
| K165 | Acetylation | Uniprot | |
| K165 | Methylation | Uniprot | |
| K165 | Ubiquitination | Uniprot | |
| S169 | Phosphorylation | Uniprot | |
| S170 | Phosphorylation | Uniprot | |
| Y172 | Phosphorylation | Uniprot | |
| T179 | Phosphorylation | Uniprot | |
| K201 | Methylation | Uniprot | |
| S202 | Phosphorylation | Uniprot | |
| S206 | Phosphorylation | Uniprot | |
| T250 | Phosphorylation | Uniprot | |
| S258 | Phosphorylation | Uniprot | |
| S259 | Phosphorylation | Uniprot | |
| K265 | Acetylation | Uniprot | |
| K265 | Ubiquitination | Uniprot | |
| S267 | Phosphorylation | Uniprot | |
| T270 | Phosphorylation | Uniprot | |
| K272 | Acetylation | Uniprot | |
| K272 | Methylation | Uniprot | |
| K272 | Ubiquitination | Uniprot | |
| T274 | Phosphorylation | Uniprot | |
| S278 | Phosphorylation | Uniprot | |
| K279 | Acetylation | Uniprot | |
| K279 | Methylation | Uniprot | |
| K279 | Ubiquitination | Uniprot | |
| S281 | Phosphorylation | Uniprot | |
| S288 | Phosphorylation | Uniprot | |
| S290 | Phosphorylation | Uniprot | |
| K295 | Ubiquitination | Uniprot | |
| S303 | Phosphorylation | P24941 (CDK2) | Uniprot |
| T306 | Phosphorylation | P24941 (CDK2) | Uniprot |
| S308 | Phosphorylation | P24941 (CDK2) | Uniprot |
| S313 | Phosphorylation | Uniprot | |
| T315 | Phosphorylation | Uniprot | |
| Y316 | Phosphorylation | Uniprot | |
| K328 | Ubiquitination | Uniprot | |
| R343 | Methylation | Uniprot | |
| S344 | Phosphorylation | Uniprot | |
| T352 | Phosphorylation | Uniprot | |
| S505 | Phosphorylation | Uniprot | |
| K528 | Acetylation | Uniprot |
研究背景
Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity).
Cytoplasm. Cytoplasm>Cytoskeleton. Nucleus. Cell junction>Focal adhesion.
Note: Associates with the actin cytoskeleton near the adhesion plaques. Enters the nucleus in the presence of HESX1.
Interacts with HPV type 6 protein E6. Does not interact significantly with E6 proteins from HPV types 11, 16, or 18. Interacts, via the Pro-rich regions, with the EVH1 domains of ENAH, EVL and VASP. Interacts with the first LIM domain of TES. Interacts with NEBL (isoform 2). Interacts with SYNPO2.
(Microbial infection) Interacts with human papillomavirus type 6/HPV6 protein E6. Does not interact significantly with E6 proteins from HPV types 11, 16, or 18.
Belongs to the zyxin/ajuba family.
研究領域
· Cellular Processes > Cellular community - eukaryotes > Focal adhesion. (View pathway)
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