DLGAP5 Antibody - #DF6920
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF6920, RRID:AB_2838879.
折りたたみ／展開
DAP-5; DAP5; Discs large homolog 7; Disks large associated protein 5; Disks large associated protein DLG7; Disks large-associated protein 5; Disks large-associated protein DLG7; DLG 1; DLG 7; DLG1; DLG7; DLGAP5; DLGP5_HUMAN; Drosophila discs large 1 tumor suppressor like; Hepatoma up regulated protein; Hepatoma up-regulated protein; Hepatoma upregulated protein; HURP; KIAA0008;
免疫原
Abundantly expressed in fetal liver. Expressed at lower levels in bone marrow, testis, colon, and placenta.
- Q15398 DLGP5_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSSSHFASRHRKDISTEMIRTKIAHRKSLSQKENRHKEYERNRHFGLKDVNIPTLEGRILVELDETSQGLVPEKTNVKPRAMKTILGDQRKQMLQKYKEEKQLQKLKEQREKAKRGIFKVGRYRPDMPCFLLSNQNAVKAEPKKAIPSSVRITRSKAKDQMEQTKIDNESDVRAIRPGPRQTSEKKVSDKEKKVVQPVMPTSLRMTRSATQAAKQVPRTVSSTTARKPVTRAANENEPEGKVPSKGRPAKNVETKPDKGISCKVDSEENTLNSQTNATSGMNPDGVLSKMENLPEINTAKIKGKNSFAPKDFMFQPLDGLKTYQVTPMTPRSANAFLTPSYTWTPLKTEVDESQATKEILAQKCKTYSTKTIQQDSNKLPCPLGPLTVWHEEHVLNKNEATTKNLNGLPIKEVPSLERNEGRIAQPHHGVPYFRNILQSETEKLTSHCFEWDRKLELDIPDDAKDLIRTAVGQTRLLMKERFKQFEGLVDDCEYKRGIKETTCTDLDGFWDMVSFQIEDVIHKFNNLIKLEESGWQVNNNMNHNMNKNVFRKKVVSGIASKPKQDDAGRIAARNRLAAIKNAMRERIRQEECAETAVSVIPKEVDKIVFDAGFFRVESPVKLFSGLSVSSEGPSQRLGTPKSVNKAVSQSRNEMGIPQQTTSPENAGPQNTKSEHVKKTLFLSIPESRSSIEDAQCPGLPDLIEENHVVNKTDLKVDCLSSERMSLPLLAGGVADDINTNKKEGISDVVEGMELNSSITSQDVLMSSPEKNTASQNSILEEGETKISQSELFDNKSLTTECHLLDSPGLNCSNPFTQLERRHQEHARHISFGGNLITFSPLQPGEF
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q15398 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S8 | Phosphorylation | Uniprot | |
| S15 | Phosphorylation | Uniprot | |
| S28 | Phosphorylation | Uniprot | |
| S30 | Phosphorylation | Uniprot | |
| S67 | Phosphorylation | Uniprot | |
| T84 | Phosphorylation | Uniprot | |
| K158 | Methylation | Uniprot | |
| T182 | Phosphorylation | Uniprot | |
| S188 | Phosphorylation | Uniprot | |
| K192 | Acetylation | Uniprot | |
| K193 | Sumoylation | Uniprot | |
| T201 | Phosphorylation | Uniprot | |
| S202 | Phosphorylation | Uniprot | |
| R204 | Methylation | Uniprot | |
| T219 | Phosphorylation | Uniprot | |
| S221 | Phosphorylation | Uniprot | |
| T224 | Phosphorylation | Uniprot | |
| S306 | Phosphorylation | Uniprot | |
| K310 | Ubiquitination | Uniprot | |
| T326 | Phosphorylation | Uniprot | |
| T329 | Phosphorylation | P28482 (MAPK1) , P06493 (CDK1) | Uniprot |
| S332 | Phosphorylation | Uniprot | |
| T338 | Phosphorylation | Uniprot | |
| S340 | Phosphorylation | Uniprot | |
| T342 | Phosphorylation | P24941 (CDK2) | Uniprot |
| T344 | Phosphorylation | P24941 (CDK2) | Uniprot |
| K347 | Sumoylation | Uniprot | |
| K347 | Ubiquitination | Uniprot | |
| T348 | Phosphorylation | Uniprot | |
| S353 | Phosphorylation | Uniprot | |
| T356 | Phosphorylation | Uniprot | |
| K357 | Ubiquitination | Uniprot | |
| K363 | Ubiquitination | Uniprot | |
| S368 | Phosphorylation | Uniprot | |
| K370 | Ubiquitination | Uniprot | |
| S376 | Phosphorylation | Uniprot | |
| K397 | Ubiquitination | Uniprot | |
| T401 | Phosphorylation | Uniprot | |
| T402 | Phosphorylation | Uniprot | |
| K403 | Ubiquitination | Uniprot | |
| K411 | Ubiquitination | Uniprot | |
| S415 | Phosphorylation | Uniprot | |
| T441 | Phosphorylation | Uniprot | |
| K443 | Ubiquitination | Uniprot | |
| K454 | Ubiquitination | Uniprot | |
| K464 | Ubiquitination | Uniprot | |
| T469 | Phosphorylation | Uniprot | |
| K483 | Ubiquitination | Uniprot | |
| K495 | Ubiquitination | Uniprot | |
| K529 | Ubiquitination | Uniprot | |
| K547 | Ubiquitination | Uniprot | |
| K553 | Ubiquitination | Uniprot | |
| K561 | Ubiquitination | Uniprot | |
| K580 | Ubiquitination | Uniprot | |
| S618 | Phosphorylation | P06493 (CDK1) | Uniprot |
| S624 | Phosphorylation | Uniprot | |
| S627 | Phosphorylation | O14965 (AURKA) | Uniprot |
| S629 | Phosphorylation | Uniprot | |
| S630 | Phosphorylation | Uniprot | |
| S634 | Phosphorylation | Uniprot | |
| T639 | Phosphorylation | P06493 (CDK1) | Uniprot |
| S642 | Phosphorylation | Uniprot | |
| K645 | Ubiquitination | Uniprot | |
| T661 | Phosphorylation | Uniprot | |
| S662 | Phosphorylation | Uniprot | |
| T671 | Phosphorylation | Uniprot | |
| S687 | Phosphorylation | Uniprot | |
| S689 | Phosphorylation | Uniprot | |
| S690 | Phosphorylation | Uniprot | |
| K711 | Ubiquitination | Uniprot | |
| K715 | Ubiquitination | Uniprot | |
| S720 | Phosphorylation | Uniprot | |
| S721 | Phosphorylation | Uniprot | |
| S725 | Phosphorylation | O14965 (AURKA) | Uniprot |
| S757 | Phosphorylation | O14965 (AURKA) | Uniprot |
| T759 | Phosphorylation | Uniprot | |
| S767 | Phosphorylation | Uniprot | |
| S774 | Phosphorylation | Uniprot | |
| S777 | Phosphorylation | Uniprot | |
| T784 | Phosphorylation | Uniprot | |
| K785 | Ubiquitination | Uniprot | |
| S787 | Phosphorylation | Uniprot | |
| S789 | Phosphorylation | Uniprot | |
| S796 | Phosphorylation | Uniprot | |
| T798 | Phosphorylation | Uniprot | |
| T799 | Phosphorylation | Uniprot | |
| S806 | Phosphorylation | Uniprot | |
| S812 | Phosphorylation | Uniprot | |
| T816 | Phosphorylation | Uniprot | |
| S830 | Phosphorylation | O14965 (AURKA) | Uniprot |
| T837 | Phosphorylation | Uniprot | |
| S839 | Phosphorylation | P06493 (CDK1) | Uniprot |
研究背景
Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells.
Ubiquitinated, leading to its degradation.
Decreased phosphorylation levels are associated with the differentiation of intestinal epithelial cells.
Nucleus. Cytoplasm. Cytoplasm>Cytoskeleton>Spindle.
Note: Localizes to the spindle in mitotic cells. Colocalizes with CDH1 at sites of cell-cell contact in intestinal epithelial cells.
Abundantly expressed in fetal liver. Expressed at lower levels in bone marrow, testis, colon, and placenta.
Interacts with CDK1. Interacts with the C-terminal proline-rich region of FBXO7. Recruited by FBXO7 to a SCF (SKP1-CUL1-F-box) protein complex in a CDK1/Cyclin B-phosphorylation dependent manner. Interacts with CDH1.
Belongs to the SAPAP family.
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