NUP62 Antibody - #DF6968
| 製品: | NUP62 Antibody |
| カタログ: | DF6968 |
| タンパク質の説明: | Rabbit polyclonal antibody to NUP62 |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Sheep, Dog, Chicken, Xenopus |
| 分子量: | 53kDa; 53kD(Calculated). |
| ユニプロット: | P37198 |
| RRID: | AB_2838924 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF6968, RRID:AB_2838924.
折りたたみ／展開
62 kDa nucleoporin; DKFZp547L134; FLJ20822; FLJ43869; IBSN; MGC841; Nuclear pore glycoprotein p62; nucleoporin 62kDa; Nucleoporin Nup62; nucleoporin p62; nucleoporin p62KD; NUP62; NUP62 protein; p62; SNDI;
免疫原
- P37198 NUP62_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSGFNFGGTGAPTGGFTFGTAKTATTTPATGFSFSTSGTGGFNFGAPFQPATSTPSTGLFSLATQTPATQTTGFTFGTATLASGGTGFSLGIGASKLNLSNTAATPAMANPSGFGLGSSNLTNAISSTVTSSQGTAPTGFVFGPSTTSVAPATTSGGFSFTGGSTAQPSGFNIGSAGNSAQPTAPATLPFTPATPAATTAGATQPAAPTPTATITSTGPSLFASIATAPTSSATTGLSLCTPVTTAGAPTAGTQGFSLKAPGAASGTSTTTSTAATATATTTSSSSTTGFALNLKPLAPAGIPSNTAAAVTAPPGPGAAAGAAASSAMTYAQLESLINKWSLELEDQERHFLQQATQVNAWDRTLIENGEKITSLHREVEKVKLDQKRLDQELDFILSQQKELEDLLSPLEELVKEQSGTIYLQHADEEREKTYKLAENIDAQLKRMAQDLKDIIEHLNTSGAPADTSDPLQQICKILNAHMDSLQWIDQNSALLQRKVEEVTKVCEGRRKEQERSFRITFD
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P37198 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Acetylation | Uniprot | |
| S2 | Phosphorylation | Uniprot | |
| T20 | Phosphorylation | Uniprot | |
| T269 | Phosphorylation | Uniprot | |
| S272 | Phosphorylation | Uniprot | |
| T281 | Phosphorylation | Uniprot | |
| K371 | Ubiquitination | Uniprot | |
| S408 | Phosphorylation | Uniprot | |
| K415 | Ubiquitination | Uniprot | |
| S418 | Phosphorylation | Uniprot | |
| Y422 | Phosphorylation | Uniprot | |
| Y434 | Phosphorylation | Uniprot | |
| K435 | Ubiquitination | Uniprot | |
| K445 | Ubiquitination | Uniprot | |
| K452 | Ubiquitination | Uniprot | |
| S468 | Phosphorylation | Uniprot | |
| K476 | Ubiquitination | Uniprot | |
| K498 | Ubiquitination | Uniprot | |
| K504 | Ubiquitination | Uniprot | |
| S516 | Phosphorylation | Uniprot | |
| T520 | Phosphorylation | Uniprot |
研究背景
Essential component of the nuclear pore complex. The N-terminal is probably involved in nucleocytoplasmic transport. The C-terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of p62 to the pore complex. Plays a role in mitotic cell cycle progression by regulating centrosome segregation, centriole maturation and spindle orientation. It might be involved in protein recruitment to the centrosome after nuclear breakdown.
O-glycosylated. Contains about 10 N-acetylglucosamine side chain sites predicted for the entire protein, among which only one in the C-terminal.
The inner channel of the NPC has a different redox environment from the cytoplasm and allows the formation of interchain disulfide bonds between some nucleoporins, the significant increase of these linkages upon oxidative stress reduces the permeability of the NPC.
Nucleus>Nuclear pore complex. Cytoplasm>Cytoskeleton>Spindle pole. Nucleus envelope. Cytoplasm>Cytoskeleton>Microtubule organizing center>Centrosome.
Note: Central region of the nuclear pore, within the transporter (PubMed:1915414). During mitotic cell division, it associates with the poles of the mitotic spindle (PubMed:24107630).
Component of the p62 complex, a complex at least composed of NUP62, NUP54, and NUP58 (By similarity). Interacts with NUP88. Interacts with NUTF2 (By similarity). Interacts with HIKESHI. Interacts with OSBPL8. Interacts with CAPG. Interacts with SAS6 and TUBG1 at the centrosome. Interacts with MCM3AP isoform GANP.
(Microbial infection) Interacts with Epstein-barr virus BGLF4; this interaction allows BGLF4 nuclear entry.
Contains FG repeats.
Belongs to the nucleoporin NSP1/NUP62 family.
研究領域
· Genetic Information Processing > Translation > RNA transport.
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