PSMA4 Antibody - #DF6976
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF6976, RRID:AB_2838932.
折りたたみ／展開
HC9; HsT17706; Macropain subunit C9; MGC111191; MGC12467; MGC24813; Multicatalytic endopeptidase complex subunit C9; Proteasome (prosome macropain) subunit alpha type 4; Proteasome alpha 4 subunit; Proteasome component C9; Proteasome subunit alpha type 4; Proteasome subunit alpha type-4; Proteasome subunit HC9; Proteasome subunit L; PSA4_HUMAN; PSC9; PSMA 4; psmA4;
免疫原
- P25789 PSA4_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSRRYDSRTTIFSPEGRLYQVEYAMEAIGHAGTCLGILANDGVLLAAERRNIHKLLDEVFFSEKIYKLNEDMACSVAGITSDANVLTNELRLIAQRYLLQYQEPIPCEQLVTALCDIKQAYTQFGGKRPFGVSLLYIGWDKHYGFQLYQSDPSGNYGGWKATCIGNNSAAAVSMLKQDYKEGEMTLKSALALAIKVLNKTMDVSKLSAEKVEIATLTRENGKTVIRVLKQKEVEQLIKKHEEEEAKAEREKKEKEQKEKDK
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P25789 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S13 | Phosphorylation | Uniprot | |
| K54 | Ubiquitination | Uniprot | |
| S62 | Phosphorylation | Uniprot | |
| K64 | Ubiquitination | Uniprot | |
| K67 | Ubiquitination | Uniprot | |
| S75 | Phosphorylation | Uniprot | |
| T80 | Phosphorylation | Uniprot | |
| S81 | Phosphorylation | Uniprot | |
| Y121 | Phosphorylation | Uniprot | |
| K127 | Acetylation | Uniprot | |
| K127 | Sumoylation | Uniprot | |
| K127 | Ubiquitination | Uniprot | |
| Y143 | Phosphorylation | Uniprot | |
| Y148 | Phosphorylation | Uniprot | |
| K160 | Acetylation | Uniprot | |
| K160 | Sumoylation | Uniprot | |
| K160 | Ubiquitination | Uniprot | |
| S168 | Phosphorylation | Uniprot | |
| S173 | Phosphorylation | Uniprot | |
| K176 | Acetylation | Uniprot | |
| K176 | Ubiquitination | Uniprot | |
| K180 | Ubiquitination | Uniprot | |
| K187 | Ubiquitination | Uniprot | |
| S188 | Phosphorylation | Uniprot | |
| K195 | Ubiquitination | Uniprot | |
| K199 | Ubiquitination | Uniprot | |
| K205 | Ubiquitination | Uniprot | |
| K210 | Acetylation | Uniprot | |
| K210 | Ubiquitination | Uniprot | |
| K222 | Ubiquitination | Uniprot | |
| T223 | Phosphorylation | Uniprot | |
| K231 | Acetylation | Uniprot | |
| K231 | Ubiquitination | Uniprot | |
| K238 | Acetylation | Uniprot | |
| K238 | Ubiquitination | Uniprot | |
| K246 | Ubiquitination | Uniprot |
研究背景
Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).
Cytoplasm. Nucleus.
Note: Colocalizes with TRIM5 in the cytoplasmic bodies.
The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7.
(Microbial infection) Interaction with HTLV-1 TAX protein favors NFKB1 activation.
Belongs to the peptidase T1A family.
研究領域
· Genetic Information Processing > Folding, sorting and degradation > Proteasome.
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