NDUFS1 Antibody - #DF7041
(1)
(2)
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF7041, RRID:AB_2838997.
折りたたみ／展開
CI-75kD; Complex I 75Kd; Complex I, mitochondrial respiratory chain, 75 kD subunit; Complex I-75kD; mitochondrial; NADH coenzyme Q reductase; NADH dehydrogenase (ubiquinone) FeS protein 1 (75kD) (NADH coenzyme Q reductase); NADH ubiquinone oxidoreductase 75 kDa subunit mitochondrial; NADH-ubiquinone oxidoreductase 75 kDa subunit; NDUFS1; NDUS1_HUMAN; PRO1304;
免疫原
- P28331 NDUS1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLRIPVRKALVGLSKSPKGCVRTTATAASNLIEVFVDGQSVMVEPGTTVLQACEKVGMQIPRFCYHERLSVAGNCRMCLVEIEKAPKVVAACAMPVMKGWNILTNSEKSKKAREGVMEFLLANHPLDCPICDQGGECDLQDQSMMFGNDRSRFLEGKRAVEDKNIGPLVKTIMTRCIQCTRCIRFASEIAGVDDLGTTGRGNDMQVGTYIEKMFMSELSGNIIDICPVGALTSKPYAFTARPWETRKTESIDVMDAVGSNIVVSTRTGEVMRILPRMHEDINEEWISDKTRFAYDGLKRQRLTEPMVRNEKGLLTYTSWEDALSRVAGMLQSFQGKDVAAIAGGLVDAEALVALKDLLNRVDSDTLCTEEVFPTAGAGTDLRSNYLLNTTIAGVEEADVVLLVGTNPRFEAPLFNARIRKSWLHNDLKVALIGSPVDLTYTYDHLGDSPKILQDIASGSHPFSQVLKEAKKPMVVLGSSALQRNDGAAILAAVSSIAQKIRMTSGVTGDWKVMNILHRIASQVAALDLGYKPGVEAIRKNPPKVLFLLGADGGCITRQDLPKDCFIIYQGHHGDVGAPIADVILPGAAYTEKSATYVNTEGRAQQTKVAVTPPGLAREDWKIIRALSEIAGMTLPYDTLDQVRNRLEEVSPNLVRYDDIEGANYFQQANELSKLVNQQLLADPLVPPQLTIKDFYMTDSISRASQTMAKCVKAVTEGAQAVEEPSIC
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P28331 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S14 | Phosphorylation | Uniprot | |
| K15 | Ubiquitination | Uniprot | |
| S16 | Phosphorylation | Uniprot | |
| K84 | Acetylation | Uniprot | |
| K108 | Ubiquitination | Uniprot | |
| K157 | Methylation | Uniprot | |
| K163 | Ubiquitination | Uniprot | |
| T239 | Phosphorylation | Uniprot | |
| K289 | Acetylation | Uniprot | |
| K289 | Ubiquitination | Uniprot | |
| K298 | Methylation | Uniprot | |
| K298 | Ubiquitination | Uniprot | |
| K311 | Acetylation | Uniprot | |
| K311 | Ubiquitination | Uniprot | |
| Y316 | Phosphorylation | Uniprot | |
| T317 | Phosphorylation | Uniprot | |
| K420 | Ubiquitination | Uniprot | |
| S434 | Phosphorylation | Uniprot | |
| T439 | Phosphorylation | Uniprot | |
| Y440 | Phosphorylation | Uniprot | |
| T441 | Phosphorylation | Uniprot | |
| S448 | Phosphorylation | Uniprot | |
| K450 | Ubiquitination | Uniprot | |
| K467 | Acetylation | Uniprot | |
| K467 | Ubiquitination | Uniprot | |
| K470 | Ubiquitination | Uniprot | |
| K471 | Ubiquitination | Uniprot | |
| S478 | Phosphorylation | Uniprot | |
| S479 | Phosphorylation | Uniprot | |
| K499 | Acetylation | Uniprot | |
| K499 | Ubiquitination | Uniprot | |
| T503 | Phosphorylation | Uniprot | |
| S504 | Phosphorylation | Uniprot | |
| T507 | Phosphorylation | Uniprot | |
| K531 | Ubiquitination | Uniprot | |
| K607 | Ubiquitination | Uniprot | |
| T611 | Phosphorylation | Uniprot | |
| K621 | Ubiquitination | Uniprot | |
| R624 | Methylation | Uniprot | |
| T697 | Phosphorylation | Uniprot | |
| K709 | Ubiquitination | Uniprot | |
| C710 | S-Nitrosylation | Uniprot | |
| C727 | S-Nitrosylation | Uniprot |
研究背景
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). This is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized.
Mitochondrion inner membrane.
Complex I is composed of 45 different subunits.
Belongs to the complex I 75 kDa subunit family.
研究領域
· Human Diseases > Endocrine and metabolic diseases > Non-alcoholic fatty liver disease (NAFLD).
· Human Diseases > Neurodegenerative diseases > Alzheimer's disease.
· Human Diseases > Neurodegenerative diseases > Parkinson's disease.
· Human Diseases > Neurodegenerative diseases > Huntington's disease.
· Metabolism > Energy metabolism > Oxidative phosphorylation.
· Metabolism > Global and overview maps > Metabolic pathways.
· Organismal Systems > Nervous system > Retrograde endocannabinoid signaling. (View pathway)
参考文献
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.