Cytokeratin 4 Antibody - #DF7050
| 製品: | Cytokeratin 4 Antibody |
| カタログ: | DF7050 |
| タンパク質の説明: | Rabbit polyclonal antibody to Cytokeratin 4 |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Horse, Sheep, Rabbit |
| 分子量: | 57kDa; 56kD(Calculated). |
| ユニプロット: | P19013 |
| RRID: | AB_2839006 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF7050, RRID:AB_2839006.
折りたたみ／展開
CK 4; CK-4; CK4; CYK4; Cytokeratin 4; Cytokeratin-4; Cytokeratin4; FLJ31692; K2C4_HUMAN; K4; Keratin 4; Keratin; Keratin type II cytoskeletal 4; Keratin-4; Keratin4; KRT 4; Krt4; type II cytoskeletal 4; Type-II keratin Kb4;
免疫原
Detected in the suprabasal layer of the stratified epithelium of the esophagus, exocervix, vagina, mouth and lingual mucosa, and in cells and cell clusters in the mucosa and serous gland ducts of the esophageal submucosa (at protein level). Expressed widely in the exocervix and esophageal epithelium, with lowest levels detected in the basal cell layer.
- P19013 K2C4_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MIARQQCVRGGPRGFSCGSAIVGGGKRGAFSSVSMSGGAGRCSSGGFGSRSLYNLRGNKSISMSVAGSRQGACFGGAGGFGTGGFGGGFGGSFSGKGGPGFPVCPAGGIQEVTINQSLLTPLHVEIDPEIQKVRTEEREQIKLLNNKFASFIDKVQFLEQQNKVLETKWNLLQQQTTTTSSKNLEPLFETYLSVLRKQLDTLGNDKGRLQSELKTMQDSVEDFKTKYEEEINKRTAAENDFVVLKKDVDAAYLNKVELEAKVDSLNDEINFLKVLYDAELSQMQTHVSDTSVVLSMDNNRNLDLDSIIAEVRAQYEEIAQRSKAEAEALYQTKVQQLQISVDQHGDNLKNTKSEIAELNRMIQRLRAEIENIKKQCQTLQVSVADAEQRGENALKDAHSKRVELEAALQQAKEELARMLREYQELMSVKLALDIEIATYRKLLEGEEYRMSGECQSAVSISVVSGSTSTGGISGGLGSGSGFGLSSGFGSGSGSGFGFGGSVSGSSSSKIISTTTLNKRR
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P19013 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S16 | Phosphorylation | Uniprot | |
| S19 | Phosphorylation | Uniprot | |
| K26 | Acetylation | Uniprot | |
| S31 | Phosphorylation | Uniprot | |
| S32 | Phosphorylation | Uniprot | |
| S34 | Phosphorylation | Uniprot | |
| S36 | Phosphorylation | Uniprot | |
| S49 | Phosphorylation | Uniprot | |
| S51 | Phosphorylation | Uniprot | |
| Y53 | Phosphorylation | Uniprot | |
| S60 | Phosphorylation | Uniprot | |
| S64 | Phosphorylation | Uniprot | |
| S68 | Phosphorylation | Uniprot | |
| K161 | Ubiquitination | Uniprot | |
| S164 | Phosphorylation | Uniprot | |
| K168 | Ubiquitination | Uniprot | |
| Y241 | Phosphorylation | Uniprot | |
| K259 | Acetylation | Uniprot | |
| Y266 | Phosphorylation | Uniprot | |
| K269 | Acetylation | Uniprot | |
| Y329 | Phosphorylation | Uniprot | |
| Y344 | Phosphorylation | Uniprot | |
| T346 | Phosphorylation | Uniprot | |
| S413 | Phosphorylation | Uniprot | |
| Y436 | Phosphorylation | Uniprot | |
| S441 | Phosphorylation | Uniprot | |
| Y462 | Phosphorylation | Uniprot |
研究背景
Detected in the suprabasal layer of the stratified epithelium of the esophagus, exocervix, vagina, mouth and lingual mucosa, and in cells and cell clusters in the mucosa and serous gland ducts of the esophageal submucosa (at protein level). Expressed widely in the exocervix and esophageal epithelium, with lowest levels detected in the basal cell layer.
Heterotetramer of two type I and two type II keratins. Keratin-4 is generally associated with keratin-13.
Belongs to the intermediate filament family.
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