GNA11 Antibody - #DF7067
| 製品: | GNA11 Antibody |
| カタログ: | DF7067 |
| タンパク質の説明: | Rabbit polyclonal antibody to GNA11 |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat, Pig |
| 予測: | Pig, Bovine, Horse, Sheep, Dog, Chicken, Xenopus |
| 分子量: | 42kDa; 42kD(Calculated). |
| ユニプロット: | P29992 |
| RRID: | AB_2839023 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF7067, RRID:AB_2839023.
折りたたみ／展開
G alpha 11; G alpha q; G protein subunit alpha 11; GAQ; GNA 11; GNA11; GNAQ; Guanine nucleotide binding protein (G protein) alpha 11 (Gq class); Guanine nucleotide binding protein (G protein) alpha 11; Guanine nucleotide binding protein (G protein) q polypeptide; Guanine nucleotide binding protein alpha q; Guanine nucleotide binding protein G(q) subunit alpha; Guanine nucleotide binding protein G(y) subunit alpha; Guanine nucleotide binding protein Gq class GNA11; Guanine nucleotide binding protein subunit alpha 11;
免疫原
- P29992 GNA11_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MTLESMMACCLSDEVKESKRINAEIEKQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGAGYSEEDKRGFTKLVYQNIFTAMQAMIRAMETLKILYKYEQNKANALLIREVDVEKVTTFEHQYVSAIKTLWEDPGIQECYDRRREYQLSDSAKYYLTDVDRIATLGYLPTQQDVLRVRVPTTGIIEYPFDLENIIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLVESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEDKILYSHLVDYFPEFDGPQRDAQAAREFILKMFVDLNPDSDKIIYSHFTCATDTENIRFVFAAVKDTILQLNLKEYNLV
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P29992 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K16 | Ubiquitination | Uniprot | |
| R20 | Methylation | Uniprot | |
| K27 | Ubiquitination | Uniprot | |
| S50 | Phosphorylation | Uniprot | |
| K52 | Ubiquitination | Uniprot | |
| S68 | Phosphorylation | Uniprot | |
| K72 | Ubiquitination | Uniprot | |
| K98 | Ubiquitination | Uniprot | |
| K102 | Sumoylation | Uniprot | |
| K102 | Ubiquitination | Uniprot | |
| K107 | Ubiquitination | Uniprot | |
| K120 | Ubiquitination | Uniprot | |
| K133 | Ubiquitination | Uniprot | |
| C144 | S-Nitrosylation | Uniprot | |
| S154 | Phosphorylation | Uniprot | |
| K158 | Ubiquitination | Uniprot | |
| T162 | Phosphorylation | Uniprot | |
| T169 | Phosphorylation | Uniprot | |
| K252 | Ubiquitination | Uniprot | |
| K282 | Ubiquitination | Uniprot | |
| Y291 | Phosphorylation | Uniprot | |
| K345 | Ubiquitination | Uniprot | |
| K354 | Ubiquitination | Uniprot |
研究背景
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C.
(Microbial infection) Deamidated at Gln-209 by Photorhabdus asymbiotica toxin PAU_02230, blocking GTP hydrolysis of heterotrimeric GNAQ or GNA11 and G-alphai (GNAI1, GNAI2 or GNAI3) proteins, thereby activating RhoA.
Cell membrane>Lipid-anchor. Cytoplasm.
Note: In testicular cells, expressed exclusively in the cytoplasm.
Expressed in testis.
G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with RGS22. Interacts with NTSR1.
Belongs to the G-alpha family. G(q) subfamily.
研究領域
· Cellular Processes > Cellular community - eukaryotes > Gap junction. (View pathway)
· Environmental Information Processing > Signal transduction > Calcium signaling pathway. (View pathway)
· Environmental Information Processing > Signal transduction > cGMP-PKG signaling pathway. (View pathway)
· Human Diseases > Infectious diseases: Parasitic > Chagas disease (American trypanosomiasis).
· Human Diseases > Infectious diseases: Parasitic > Amoebiasis.
· Human Diseases > Cancers: Overview > Pathways in cancer. (View pathway)
· Organismal Systems > Circulatory system > Vascular smooth muscle contraction. (View pathway)
· Organismal Systems > Nervous system > Cholinergic synapse.
· Organismal Systems > Nervous system > Long-term depression.
· Organismal Systems > Endocrine system > Insulin secretion. (View pathway)
· Organismal Systems > Endocrine system > Aldosterone synthesis and secretion.
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