NEUROG3 Antibody - #DF7077

(2)  
製品: NEUROG3 Antibody
カタログ: DF7077
タンパク質の説明: Rabbit polyclonal antibody to NEUROG3
アプリケーション: WB IHC
反応性: Human, Mouse, Rat
予測: Pig, Rabbit
分子量: 23kDa; 23kD(Calculated).
ユニプロット: Q9Y4Z2
RRID: AB_2839033

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関連ダウンロード
MS Report
HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:1000, IHC 1:50-1:100
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
予測:
Pig(80%), Rabbit(100%)
クローナリティ:
Polyclonal
特異性:
NEUROG3 Antibody detects endogenous levels of total NEUROG3.
RRID:
AB_2839033
引用形式: Affinity Biosciences Cat# DF7077, RRID:AB_2839033.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

ATH4B; Atoh5; bHLHa7; Class A basic helix-loop-helix protein 7; Math4B; NEUROG3; Neurogenin-3; NGN-3; ngn3; NGN3_HUMAN; OTTHUMP00000019730; Protein atonal homolog 5;

免疫原

免疫原:
Uniprot:

Q9Y4Z2(NGN3_HUMAN) >>Visit HPA database.

遺伝子(ID):
NEUROG3(50674)
タンパク質の説明:
Neurogenin-3 is a protein that in humans is encoded by the NEUROG3 gene. Neurogenin-3 is expressed in endocrine progenitor cells and is required for endocrine cell development in the pancreas and intestine. It belongs to a family of basic helix-loop-helix (bHLH) transcription factors involved in the determination of neural precursor cells in the neuroectoderm. The pancreas and brain the major splicing isoform does not code for a protein. Acts as a transcriptional regulator. Together with NKX2-2, initiates transcriptional activation of NEUROD1.
タンパク質配列:
MTPQPSGAPTVQVTRETERSFPRASEDEVTCPTSAPPSPTRTRGNCAEAEEGGCRGAPRKLRARRGGRSRPKSELALSKQRRSRRKKANDRERNRMHNLNSALDALRGVLPTFPDDAKLTKIETLRFAHNYIWALTQTLRIADHSLYALEPPAPHCGELGSPGGSPGDWGSLYSPVSQAGSLSPAASLEERPGLLGATFSACLSPGSLAFSDFL

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Rabbit
100
Pig
80
Bovine
78
Sheep
78
Dog
70
Horse
0
Xenopus
0
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q9Y4Z2 基板として

Site PTM Type Enzyme
T112 Phosphorylation
S174 Phosphorylation
S183 Phosphorylation

研究背景

機能:

Acts as a transcriptional regulator. Together with NKX2-2, initiates transcriptional activation of NEUROD1. Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types (By similarity).

細胞の位置付け:

Nucleus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
サブユニット構造:

Efficient DNA binding requires dimerization with another bHLH protein. Interacts with ATOH8.

研究領域

· Human Diseases > Endocrine and metabolic diseases > Maturity onset diabetes of the young.

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