RAMP2 Antibody - #DF7173

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製品: RAMP2 Antibody
カタログ: DF7173
タンパク質の説明: Rabbit polyclonal antibody to RAMP2
アプリケーション: WB IHC
反応性: Human, Mouse, Rat
分子量: 20kD; 20kD(Calculated).
ユニプロット: O60895
RRID: AB_2839125

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MS Report
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MSDS
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WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
クローナリティ:
Polyclonal
特異性:
RAMP2 Antibody detects endogenous levels of total RAMP2.
RRID:
AB_2839125
引用形式: Affinity Biosciences Cat# DF7173, RRID:AB_2839125.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

Calcitonin receptor like receptor activity modifying protein 2; Calcitonin-receptor-like receptor activity-modifying protein 2; CRLR activity modifying protein 2; CRLR activity-modifying protein 2; OTTMUSP00000002615; OTTMUSP00000037624; RAMP2; RAMP2_HUMAN; Receptor (calcitonin) activity modifying protein 2; Receptor activity modifying protein 2; Receptor activity modifying protein 2 isoform; Receptor activity-modifying protein 2; RP23-281C18.6;

免疫原

免疫原:
Uniprot:

O60895(RAMP2_HUMAN) >>Visit HPA database.

遺伝子(ID):
RAMP2(10266)
発現特異性:
O60895 RAMP2_HUMAN:

Strongly expressed in lung, breast, immune system and fetal tissues.

タンパク質配列:
MASLRVERAGGPRLPRTRVGRPAALRLLLLLGAVLNPHEALAQPLPTTGTPGSEGGTVKNYETAVQFCWNHYKDQMDPIEKDWCDWAMISRPYSTLRDCLEHFAELFDLGFPNPLAERIIFETHQIHFANCSLVQPTFSDPPEDVLLAMIIAPICLIPFLITLVVWRSKDSEAQA

研究背景

機能:

Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.

細胞の位置付け:

Membrane>Single-pass type I membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Strongly expressed in lung, breast, immune system and fetal tissues.

サブユニット構造:

Heterodimer of CALCRL and RAMP2.

タンパク質ファミリー:

Belongs to the RAMP family.

研究領域

· Organismal Systems > Circulatory system > Vascular smooth muscle contraction.   (View pathway)

参考文献

1). Adrenomedullin ameliorates palmitic acid-induced insulin resistance through PI3K/Akt pathway in adipocytes. ACTA DIABETOLOGICA, 2022 (PubMed: 34978596) [IF=3.8]

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