FOXP1 Antibody - #DF7250
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF7250, RRID:AB_2839189.
折りたたみ／展開
12CC4; FLJ23741; Fork head related protein like B; Forkhead box P1; Forkhead box protein P1; FOX P1; FOXP 1; foxp1; FOXP1_HUMAN; Glutamine rich factor 1; hFKH1B; HSPC215; MGC12942; MGC88572; MGC99551; QRF 1; QRF1;
免疫原
- Q9H334 FOXP1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MMQESGTETKSNGSAIQNGSGGSNHLLECGGLREGRSNGETPAVDIGAADLAHAQQQQQQALQVARQLLLQQQQQQQVSGLKSPKRNDKQPALQVPVSVAMMTPQVITPQQMQQILQQQVLSPQQLQVLLQQQQALMLQQQQLQEFYKKQQEQLQLQLLQQQHAGKQPKEQQQVATQQLAFQQQLLQMQQLQQQHLLSLQRQGLLTIQPGQPALPLQPLAQGMIPTELQQLWKEVTSAHTAEETTGNNHSSLDLTTTCVSSSAPSKTSLIMNPHASTNGQLSVHTPKRESLSHEEHPHSHPLYGHGVCKWPGCEAVCEDFQSFLKHLNSEHALDDRSTAQCRVQMQVVQQLELQLAKDKERLQAMMTHLHVKSTEPKAAPQPLNLVSSVTLSKSASEASPQSLPHTPTTPTAPLTPVTQGPSVITTTSMHTVGPIRRRYSDKYNVPISSADIAQNQEFYKNAEVRPPFTYASLIRQAILESPEKQLTLNEIYNWFTRMFAYFRRNAATWKNAVRHNLSLHKCFVRVENVKGAVWTVDEVEFQKRRPQKISGNPSLIKNMQSSHAYCTPLNAALQASMAENSIPLYTTASMGNPTLGNLASAIREELNGAMEHTNSNESDSSPGRSPMQAVHPVHVKEEPLDPEEAEGPLSLVTTANHSPDFDHDRDYEDEPVNEDME
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9H334 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S79 | Phosphorylation | Uniprot | |
| K82 | Ubiquitination | Uniprot | |
| S83 | Phosphorylation | Uniprot | |
| K149 | Ubiquitination | Uniprot | |
| K166 | Ubiquitination | Uniprot | |
| T285 | Phosphorylation | Uniprot | |
| R336 | Methylation | Uniprot | |
| T367 | Phosphorylation | Uniprot | |
| K377 | Ubiquitination | Uniprot | |
| S440 | Phosphorylation | Uniprot | |
| K460 | Ubiquitination | Uniprot | |
| K521 | Ubiquitination | Uniprot | |
| K543 | Ubiquitination | Uniprot | |
| S615 | Phosphorylation | Uniprot | |
| S618 | Phosphorylation | Uniprot | |
| S620 | Phosphorylation | Uniprot | |
| S621 | Phosphorylation | Uniprot | |
| S625 | Phosphorylation | Uniprot | |
| K636 | Sumoylation | Uniprot | |
| S650 | Phosphorylation | Uniprot | |
| T653 | Phosphorylation | Uniprot | |
| S658 | Phosphorylation | Uniprot |
研究背景
Transcriptional repressor. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal chord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintenance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18 (By similarity). Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis. Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor. Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B. Can negatively regulate androgen receptor signaling. Acts as a transcriptional activator of the FBXL7 promoter; this activity is regulated by AURKA.
Involved in transcriptional regulation in embryonic stem cells (ESCs). Stimulates expression of transcription factors that are required for pluripotency and decreases expression of differentiation-associated genes. Has distinct DNA-binding specifities as compared to the canonical form and preferentially binds DNA with the sequence 5'-CGATACAA-3' (or closely related sequences). Promotes ESC self-renewal and pluripotency (By similarity).
Nucleus.
Note: Not found in the nucleolus.
Isoform 8 is specifically expressed in embryonic stem cells.
Forms homodimers and heterodimers with FOXP2 and FOXP4. Dimerization is required for DNA-binding. Self-associates. Interacts with CTBP1 (By similarity). Interacts with NCOR2 and AR. Interacts with FOXP2. Interacts with TBR1. Interacts with AURKA; this interaction facilitates the phosphorylation of FOXP1, which suppresses the expression of FBXL7.
The leucine-zipper is required for dimerization and transcriptional repression.
研究領域
· Human Diseases > Cancers: Overview > MicroRNAs in cancer.
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