KLC1 Antibody - #DF7392
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF7392, RRID:AB_2839330.
折りたたみ/展開
Kinesin 2 60/70kDa; Kinesin light chain 1; Kinesin2; KLC 1; KLC; Klc1; KLC1_HUMAN; KNS 2; KNS 2A; KNS2; KNS2A; Medulloblastoma antigen MU MB 2.50; MGC15245;
免疫原
- Q07866 KLC1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MYDNMSTMVYIKEDKLEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDESNLVEEKSNMIRKSLEMLELGLSEAQVMMALSNHLNAVESEKQKLRAQVRRLCQENQWLRDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLFPNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAANLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALEIYQTKLGPDDPNVAKTKNNLASCYLKQGKFKQAETLYKEILTRAHEREFGSVDDENKPIWMHAEEREECKGKQKDGTSFGEYGGWYKACKVDSPTVTTTLKNLGALYRRQGKFEAAETLEEAAMRSRKQGLDNVHKQRVAEVLNDPENMEKRRSRESLNVDVVKYESGPDGGEEVSMSVEWNGGVSGRASFCGKRQQQQWPGRRHR
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q07866 基板として
Site | PTM Type | Enzyme | Source |
---|---|---|---|
Y2 | Phosphorylation | Uniprot | |
Y10 | Phosphorylation | Uniprot | |
K18 | Ubiquitination | Uniprot | |
K54 | Ubiquitination | Uniprot | |
S75 | Phosphorylation | Uniprot | |
S134 | Phosphorylation | Uniprot | |
K146 | Ubiquitination | Uniprot | |
S162 | Phosphorylation | Uniprot | |
Y207 | Phosphorylation | Uniprot | |
K237 | Ubiquitination | Uniprot | |
Y271 | Phosphorylation | Uniprot | |
K272 | Acetylation | Uniprot | |
Y307 | Phosphorylation | Uniprot | |
K309 | Ubiquitination | Uniprot | |
Y360 | Phosphorylation | Uniprot | |
Y369 | Phosphorylation | Uniprot | |
T371 | Phosphorylation | Uniprot | |
K372 | Ubiquitination | Uniprot | |
K384 | Ubiquitination | Uniprot | |
S389 | Phosphorylation | Uniprot | |
K393 | Acetylation | Uniprot | |
K393 | Ubiquitination | Uniprot | |
S418 | Phosphorylation | Uniprot | |
K441 | Ubiquitination | Uniprot | |
S445 | Phosphorylation | Uniprot | |
Y449 | Phosphorylation | Uniprot | |
K454 | Methylation | Uniprot | |
S460 | Phosphorylation | P28482 (MAPK1) , P27361 (MAPK3) | Uniprot |
T462 | Phosphorylation | Uniprot | |
T464 | Phosphorylation | Uniprot | |
T465 | Phosphorylation | Uniprot | |
K495 | Ubiquitination | Uniprot | |
K503 | Ubiquitination | Uniprot | |
R505 | Methylation | Uniprot | |
K518 | Ubiquitination | Uniprot | |
S521 | Phosphorylation | Q13131 (PRKAA1) | Uniprot |
S524 | Phosphorylation | Uniprot | |
Y532 | Phosphorylation | Uniprot | |
S557 | Phosphorylation | Uniprot |
研究背景
Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.
Cell projection>Growth cone. Cytoplasmic vesicle. Cytoplasm>Cytoskeleton.
Found in a variety of tissues. Mostly abundant in brain and spine.
Oligomeric complex composed of two heavy chains and two light chains. Interacts with SPAG9. Interacts with ATCAY; may link mitochondria to KLC1 and regulate mitochondria localization into neuron projections (By similarity). Interacts (via TPR repeats) with TOR1A; the interaction associates TOR1A with the kinesin oligomeric complex. Interacts with BORCS5. Interacts with MAPK8IP3/JIP3 and NTRK2/TRKB; interaction with NTRK2/TRKB is mediated by MAPK8IP3/JIP3 (By similarity).
(Microbial infection) Interacts with adenovirus hexon-interlacing protein; this interaction leads to capsid disruption at the nuclear pore complex during virus entry into host cell.
Belongs to the kinesin light chain family.
研究領域
· Human Diseases > Infectious diseases: Bacterial > Salmonella infection.
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