PSME2 Antibody - #DF7402

(3)  
製品: PSME2 Antibody
カタログ: DF7402
タンパク質の説明: Rabbit polyclonal antibody to PSME2
アプリケーション: WB IHC
反応性: Human, Mouse, Rat
予測: Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Xenopus
分子量: 27kDa; 27kD(Calculated).
ユニプロット: Q9UL46
RRID: AB_2839340

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 100ul $280 在庫あり
 200ul $350 在庫あり

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関連ダウンロード
MS Report
HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
予測:
Pig(100%), Zebrafish(100%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%), Xenopus(89%)
クローナリティ:
Polyclonal
特異性:
PSME2 Antibody detects endogenous levels of total PSME2.
RRID:
AB_2839340
引用形式: Affinity Biosciences Cat# DF7402, RRID:AB_2839340.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

11S regulator complex beta subunit; 11S regulator complex subunit beta; Activator of multicatalytic protease subunit 2; Cell migration inducing protein 22; MCP activator 31 kD subunit; PA28 beta; PA28b; PA28beta; Proteasome (prosome macropain) activator subunit 2 (PA28 beta); Proteasome (prosome macropain) activator subunit 2; Proteasome activator 28 beta; Proteasome activator 28 subunit beta; Proteasome activator complex subunit 2; Proteasome activator hPA28 subunit beta; Proteasome activator subunit 2; PSME 2; PSME2; PSME2_HUMAN; REG beta; REG-beta; REGbeta;

免疫原

免疫原:
Uniprot:

Q9UL46(PSME2_HUMAN) >>Visit HPA database.

遺伝子(ID):
PSME2(5721)
タンパク質の説明:
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the beta subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three beta and three alpha subunits combine to form a heterohexameric ring. Six pseudogenes have been identified on chromosomes 4, 5, 8, 10 and 13.
タンパク質配列:
MAKPCGVRLSGEARKQVEVFRQNLFQEAEEFLYRFLPQKIIYLNQLLQEDSLNVADLTSLRAPLDIPIPDPPPKDDEMETDKQEKKEVHKCGFLPGNEKVLSLLALVKPEVWTLKEKCILVITWIQHLIPKIEDGNDFGVAIQEKVLERVNAVKTKVEAFQTTISKYFSERGDAVAKASKETHVMDYRALVHERDEAAYGELRAMVLDLRAFYAELYHIISSNLEKIVNPKGEEKPSMY

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Zebrafish
100
Rabbit
100
Xenopus
89
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q9UL46 基板として

Site PTM Type Enzyme
A2 Acetylation
K3 Methylation
K3 Ubiquitination
R8 Methylation
S10 Phosphorylation
K15 Ubiquitination
K39 Ubiquitination
S102 Phosphorylation
K108 Ubiquitination
K115 Ubiquitination
K145 Ubiquitination
T162 Phosphorylation
K166 Ubiquitination
K180 Acetylation
Y199 Phosphorylation
Y217 Phosphorylation
K235 Ubiquitination
Y239 Phosphorylation

研究背景

機能:

Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.

サブユニット構造:

Heterodimer of PSME1 and PSME2, which forms a hexameric ring.

タンパク質ファミリー:

Belongs to the PA28 family.

研究領域

· Genetic Information Processing > Folding, sorting and degradation > Proteasome.

· Organismal Systems > Immune system > Antigen processing and presentation.   (View pathway)

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