WHSC1L1 Antibody - #DF7410
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF7410, RRID:AB_2839348.
折りたたみ／展開
DKFZp667H044; FLJ20353; Histone lysine N methyltransferase NSD3; Histone-lysine N-methyltransferase NSD3; MGC126766; MGC142029; NSD 3; NSD3_HUMAN; Nuclear set domain containing 3; Nuclear SET domain containing protein 3; Nuclear SET domain-containing protein 3; pp14328; Protein whistle; Whistle; WHSC1 like protein 1; WHSC1-like 1 isoform 9 with methyltransferase activity to lysine; WHSC1-like protein 1; WHSC1L1; WHSC1L1 protein; Wolf Hirschhorn syndrome candidate 1 like 1; Wolf-Hirschhorn syndrome candidate 1-like protein 1;
免疫原
Highly expressed in brain, heart and skeletal muscle. Expressed at lower level in liver and lung.
- Q9BZ95 NSD3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDFSFSFMQGIMGNTIQQPPQLIDSANIRQEDAFDNNSDIAEDGGQTPYEATLQQGFQYPATTEDLPPLTNGYPSSISVYETQTKYQSYNQYPNGSANGFGAVRNFSPTDYYHSEIPNTRPHEILEKPSPPQPPPPPSVPQTVIPKKTGSPEIKLKITKTIQNGRELFESSLCGDLLNEVQASEHTKSKHESRKEKRKKSNKHDSSRSEERKSHKIPKLEPEEQNRPNERVDTVSEKPREEPVLKEEAPVQPILSSVPTTEVSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRGAREYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNHSEKQKIRKPRPQRERAQWDIGIAHAEKALKMTREERIEQYTFIYIDKQPEEALSQAKKSVASKTEVKKTRRPRSVLNTQPEQTNAGEVASSLSSTEIRRHSQRRHTSAEEEEPPPVKIAWKTAAARKSLPASITMHKGSLDLQKCNMSPVVKIEQVFALQNATGDGKFIDQFVYSTKGIGNKTEISVRGQDRLIISTPNQRNEKPTQSVSSPEATSGSTGSVEKKQQRRSIRTRSESEKSTEVVPKKKIKKEQVETVPQATVKTGLQKGASEISDSCKPLKKRSRASTDVEMTSSAYRDTSDSDSRGLSDLQVGFGKQVDSPSATADADVSDVQSMDSSLSRRGTGMSKKDTVCQICESSGDSLIPCEGECCKHFHLECLGLASLPDSKFICMECKTGQHPCFSCKVSGKDVKRCSVGACGKFYHEACVRKFPTAIFESKGFRCPQHCCSACSMEKDIHKASKGRMMRCLRCPVAYHSGDACIAAGSMLVSSYILICSNHSKRSSNSSAVNVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLNESNRAELMKLPMIPSSSASKKKCEKGGRLLCCESCPASFHPECLSIEMPEGCWNCNDCKAGKKLHYKQIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSFAEGQTSINKTFKKALEEAAKRFQELKAQRESKEALEIEKNSRKPPPYKHIKANKVIGKVQIQVADLSEIPRCNCKPADENPCGLESECLNRMLQYECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCLGNGRTECHCGADNCSGFLGVRPKSACASTNEEKAKNAKLKQKRRKIKTEPKQMHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPYGKWECPWHQCDECSSAAVSFCEFCPHSFCKDHEKGALVPSALEGRLCCSEHDPMAPVSPEYWSKIKCKWESQDHGEEVKE
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9BZ95 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S107 | Phosphorylation | Uniprot | |
| K127 | Ubiquitination | Uniprot | |
| S129 | Phosphorylation | Uniprot | |
| S150 | Phosphorylation | Uniprot | |
| K159 | Ubiquitination | Uniprot | |
| S183 | Phosphorylation | Uniprot | |
| T186 | Phosphorylation | Uniprot | |
| K187 | Ubiquitination | Uniprot | |
| S188 | Phosphorylation | Uniprot | |
| K218 | Sumoylation | Uniprot | |
| K245 | Sumoylation | Uniprot | |
| K334 | Ubiquitination | Uniprot | |
| K345 | Ubiquitination | Uniprot | |
| Y390 | Phosphorylation | Uniprot | |
| Y394 | Phosphorylation | Uniprot | |
| S424 | Phosphorylation | Uniprot | |
| T428 | Phosphorylation | Uniprot | |
| T433 | Phosphorylation | Uniprot | |
| T456 | Phosphorylation | Uniprot | |
| S457 | Phosphorylation | Uniprot | |
| K467 | Sumoylation | Uniprot | |
| K467 | Ubiquitination | Uniprot | |
| K471 | Ubiquitination | Uniprot | |
| K477 | Methylation | Uniprot | |
| K477 | Ubiquitination | Uniprot | |
| S478 | Phosphorylation | Uniprot | |
| K487 | Ubiquitination | Uniprot | |
| S489 | Phosphorylation | Uniprot | |
| K494 | Ubiquitination | Uniprot | |
| S498 | Phosphorylation | Uniprot | |
| Y524 | Phosphorylation | Uniprot | |
| K527 | Ubiquitination | Uniprot | |
| K532 | Acetylation | Uniprot | |
| K532 | Sumoylation | Uniprot | |
| K532 | Ubiquitination | Uniprot | |
| S546 | Phosphorylation | Uniprot | |
| T547 | Phosphorylation | Uniprot | |
| K554 | Acetylation | Uniprot | |
| K554 | Ubiquitination | Uniprot | |
| T556 | Phosphorylation | Uniprot | |
| S558 | Phosphorylation | Uniprot | |
| S560 | Phosphorylation | Uniprot | |
| S561 | Phosphorylation | Uniprot | |
| S568 | Phosphorylation | Uniprot | |
| T569 | Phosphorylation | Uniprot | |
| S571 | Phosphorylation | Uniprot | |
| S580 | Phosphorylation | Uniprot | |
| T583 | Phosphorylation | Uniprot | |
| S585 | Phosphorylation | Uniprot | |
| S587 | Phosphorylation | Uniprot | |
| S590 | Phosphorylation | Uniprot | |
| K601 | Sumoylation | Uniprot | |
| T611 | Phosphorylation | Uniprot | |
| K628 | Sumoylation | Uniprot | |
| S634 | Phosphorylation | Uniprot | |
| S637 | Phosphorylation | Uniprot | |
| T638 | Phosphorylation | Uniprot | |
| S655 | Phosphorylation | Uniprot | |
| S659 | Phosphorylation | Uniprot | |
| K667 | Methylation | Uniprot | |
| S671 | Phosphorylation | Uniprot | |
| K781 | Acetylation | Uniprot | |
| K790 | Acetylation | Uniprot | |
| S889 | Phosphorylation | Uniprot | |
| Y891 | Phosphorylation | Uniprot | |
| S896 | Phosphorylation | Uniprot | |
| K914 | Acetylation | Uniprot | |
| K915 | Acetylation | Uniprot | |
| Y960 | Phosphorylation | Uniprot | |
| Y971 | Phosphorylation | Uniprot | |
| K1058 | Sumoylation | Uniprot | |
| K1065 | Ubiquitination | Uniprot | |
| Y1073 | Phosphorylation | Uniprot | |
| K1074 | Ubiquitination | Uniprot | |
| K1077 | Acetylation | Uniprot | |
| K1080 | Acetylation | Uniprot | |
| K1141 | Ubiquitination | Uniprot | |
| K1151 | Sumoylation | Uniprot | |
| K1167 | Ubiquitination | Uniprot | |
| K1215 | Ubiquitination | Uniprot | |
| K1391 | Ubiquitination | Uniprot | |
| S1406 | Phosphorylation | Uniprot | |
| S1415 | Phosphorylation | Uniprot |
研究背景
Histone methyltransferase. Preferentially dimethylates 'Lys-4' and 'Lys-27' of histone H3 forming H3K2me2 and H3K27me2. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression.
Nucleus. Chromosome.
Highly expressed in brain, heart and skeletal muscle. Expressed at lower level in liver and lung.
Interacts with BRD4.
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.
研究領域
· Metabolism > Amino acid metabolism > Lysine degradation.
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