NDUFA10 Antibody - #DF2211
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF2211, RRID:AB_2839442.
折りたたみ／展開
CI 42KD; CI-42k; Complex I-42kD; MGC5103; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10 42kDa; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial complex I 42kDa subunit; NADH ubiquinone oxidoreductase 42 kDa subunit mitochondrial precursor; NADH-ubiquinone oxidoreductase 42 kDa subunit; ndufa10l;
免疫原
- O95299 NDUAA_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MALRLLKLAATSASARVVAAGAQRVRGIHSSVQCKLRYGMWHFLLGDKASKRLTERSRVITVDGNICTGKGKLAKEIAEKLGFKHFPEAGIHYPDSTTGDGKPLATDYNGNCSLEKFYDDPRSNDGNSYRLQSWLYSSRLLQYSDALEHLLTTGQGVVLERSIFSDFVFLEAMYNQGFIRKQCVDHYNEVKSVTICDYLPPHLVIYIDVPVPEVQRRIQKKGDPHEMKITSAYLQDIENAYKKTFLPEMSEKCEVLQYSAREAQDSKKVVEDIEYLKFDKGPWLKQDNRTLYHLRLLVQDKFEVLNYTSIPIFLPEVTIGAHQTDRVLHQFRELPGRKYSPGYNTEVGDKWIWLK
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O95299 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K48 | Ubiquitination | Uniprot | |
| S57 | Phosphorylation | Uniprot | |
| T61 | Phosphorylation | Uniprot | |
| K80 | Acetylation | Uniprot | |
| K80 | Ubiquitination | Uniprot | |
| K84 | Ubiquitination | Uniprot | |
| K102 | Ubiquitination | Uniprot | |
| K181 | Ubiquitination | Uniprot | |
| K221 | Acetylation | Uniprot | |
| T230 | Phosphorylation | Uniprot | |
| S231 | Phosphorylation | Uniprot | |
| Y233 | Phosphorylation | Uniprot | |
| Y241 | Phosphorylation | Uniprot | |
| K242 | Acetylation | Uniprot | |
| K242 | Ubiquitination | Uniprot | |
| K243 | Acetylation | Uniprot | |
| K243 | Ubiquitination | Uniprot | |
| S250 | Phosphorylation | Uniprot | |
| K252 | Ubiquitination | Uniprot | |
| K267 | Acetylation | Uniprot | |
| K268 | Ubiquitination | Uniprot | |
| Y275 | Phosphorylation | Uniprot | |
| K277 | Ubiquitination | Uniprot | |
| K280 | Ubiquitination | Uniprot | |
| K285 | Ubiquitination | Uniprot | |
| K338 | Ubiquitination | Uniprot | |
| T345 | Phosphorylation | Uniprot | |
| K350 | Ubiquitination | Uniprot |
研究背景
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Phosphorylation at Ser-250 by PINK1 is required for the binding and/or reduction of the complex I substrate ubiquinone.
Mitochondrion matrix.
Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction.
Belongs to the complex I NDUFA10 subunit family.
研究領域
· Human Diseases > Endocrine and metabolic diseases > Non-alcoholic fatty liver disease (NAFLD).
· Human Diseases > Neurodegenerative diseases > Alzheimer's disease.
· Human Diseases > Neurodegenerative diseases > Parkinson's disease.
· Human Diseases > Neurodegenerative diseases > Huntington's disease.
· Metabolism > Energy metabolism > Oxidative phosphorylation.
· Metabolism > Global and overview maps > Metabolic pathways.
· Organismal Systems > Nervous system > Retrograde endocannabinoid signaling. (View pathway)
Restrictive clause
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For Research Use Only.
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