PEX1 Antibody - #DF2221

(2)  
製品: PEX1 Antibody
カタログ: DF2221
タンパク質の説明: Rabbit polyclonal antibody to PEX1
アプリケーション: WB IHC
反応性: Human, Mouse
分子量: 142 kDa; 143kD(Calculated).
ユニプロット: O43933
RRID: AB_2839452

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MS Report
HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse
クローナリティ:
Polyclonal
特異性:
PEX1 Antibody detects endogenous levels of total PEX1.
RRID:
AB_2839452
引用形式: Affinity Biosciences Cat# DF2221, RRID:AB_2839452.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

Highly similar to ATPase [H.sapiens]; Peroxin 1; Peroxin-1; peroxin1; Peroxisome biogenesis disorder protein 1; Peroxisome biogenesis factor 1; PEX1; PEX1_HUMAN; ZWS1;

免疫原

免疫原:

A synthesized peptide derived from human PEX1, corresponding to a region within N-terminal amino acids.

Uniprot:

O43933(PEX1_HUMAN) >>Visit HPA database.

遺伝子(ID):
PEX1(5189)
タンパク質の説明:
Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes.
タンパク質配列:
MWGSDRLAGAGGGGAAVTVAFTNARDCFLHLPRRLVAQLHLLQNQAIEVVWSHQPAFLSWVEGRHFSDQGENVAEINRQVGQKLGLSNGGQVFLKPCSHVVSCQQVEVEPLSADDWEILELHAVSLEQHLLDQIRIVFPKAIFPVWVDQQTYIFIQIVALIPAASYGRLETDTKLLIQPKTRRAKENTFSKADAEYKKLHSYGRDQKGMMKELQTKQLQSNTVGITESNENESEIPVDSSSVASLWTMIGSIFSFQSEKKQETSWGLTEINAFKNMQSKVVPLDNIFRVCKSQPPSIYNASATSVFHKHCAIHVFPWDQEYFDVEPSFTVTYGKLVKLLSPKQQQSKTKQNVLSPEKEKQMSEPLDQKKIRSDHNEEDEKACVLQVVWNGLEELNNAIKYTKNVEVLHLGKVWIPDDLRKRLNIEMHAVVRITPVEVTPKIPRSLKLQPRENLPKDISEEDIKTVFYSWLQQSTTTMLPLVISEEEFIKLETKDGLKEFSLSIVHSWEKEKDKNIFLLSPNLLQKTTIQVLLDPMVKEENSEEIDFILPFLKLSSLGGVNSLGVSSLEHITHSLLGRPLSRQLMSLVAGLRNGALLLTGGKGSGKSTLAKAICKEAFDKLDAHVERVDCKALRGKRLENIQKTLEVAFSEAVWMQPSVVLLDDLDLIAGLPAVPEHEHSPDAVQSQRLAHALNDMIKEFISMGSLVALIATSQSQQSLHPLLVSAQGVHIFQCVQHIQPPNQEQRCEILCNVIKNKLDCDINKFTDLDLQHVAKETGGFVARDFTVLVDRAIHSRLSRQSISTREKLVLTTLDFQKALRGFLPASLRSVNLHKPRDLGWDKIGGLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPPGTGKTLLAGVIARESRMNFISVKGPELLSKYIGASEQAVRDIFIRAQAAKPCILFFDEFESIAPRRGHDNTGVTDRVVNQLLTQLDGVEGLQGVYVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQVSRLEILNVLSDSLPLADDVDLQHVASVTDSFTGADLKALLYNAQLEALHGMLLSSGLQDGSSSSDSDLSLSSMVFLNHSSGSDDSAGDGECGLDQSLVSLEMSEILPDESKFNMYRLYFGSSYESELGNGTSSDLSSQCLSAPSSMTQDLPGVPGKDQLFSQPPVLRTASQEGCQELTQEQRDQLRADISIIKGRYRSQSGEDESMNQPGPIKTRLAISQSHLMTALGHTRPSISEDDWKNFAELYESFQNPKRRKNQSGTMFRPGQKVTLA

PTMs - O43933 基板として

Site PTM Type Enzyme
K191 Ubiquitination
K198 Ubiquitination
Y202 Phosphorylation
K211 Ubiquitination
K260 Ubiquitination
S264 Phosphorylation
K274 Ubiquitination
S278 Phosphorylation
K279 Ubiquitination
K291 Ubiquitination
K337 Ubiquitination
K342 Ubiquitination
K349 Ubiquitination
S354 Phosphorylation
K357 Ubiquitination
K402 Ubiquitination
K411 Ubiquitination
T438 Phosphorylation
K446 Ubiquitination
K455 Ubiquitination
K513 Ubiquitination
S541 Phosphorylation
S585 Phosphorylation
K610 Ubiquitination
K614 Ubiquitination
K619 Ubiquitination
K630 Ubiquitination
K756 Ubiquitination
K763 Ubiquitination
K774 Ubiquitination
K806 Ubiquitination
T810 Phosphorylation
T811 Phosphorylation
K816 Ubiquitination
K833 Ubiquitination
K841 Ubiquitination
Y880 Phosphorylation
T885 Phosphorylation
K887 Ubiquitination
K906 Ubiquitination
K913 Ubiquitination
K933 Ubiquitination
K1001 Ubiquitination
S1172 Phosphorylation
T1179 Phosphorylation
S1181 Phosphorylation
S1201 Phosphorylation
K1204 Ubiquitination
Y1207 Phosphorylation
S1209 Phosphorylation
S1211 Phosphorylation
S1216 Phosphorylation
K1224 Ubiquitination
S1259 Phosphorylation
K1264 Ubiquitination
S1270 Phosphorylation

研究背景

機能:

Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes.

細胞の位置付け:

Cytoplasm. Peroxisome membrane.
Note: Associated with peroxisomal membranes.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
サブユニット構造:

Interacts directly with PEX6. Interacts indirectly with PEX26, via its interaction with PEX6.

タンパク質ファミリー:

Belongs to the AAA ATPase family.

研究領域

· Cellular Processes > Transport and catabolism > Peroxisome.   (View pathway)

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