RASSF7 Antibody - #DF2230
| 製品: | RASSF7 Antibody |
| カタログ: | DF2230 |
| タンパク質の説明: | Rabbit polyclonal antibody to RASSF7 |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse |
| 予測: | Horse |
| 分子量: | 40 kDa; 40kD(Calculated). |
| ユニプロット: | Q02833 |
| RRID: | AB_2839461 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF2230, RRID:AB_2839461.
折りたたみ／展開
C11orf13; Chromosome 11 open reading frame 13; HRAS1; HRAS1 related cluster 1; HRAS1 related cluster protein 1; HRAS1-related cluster protein 1; HRC1; MGC126069; MGC126070; Ras association (RalGDS/AF 6) domain family (N terminal) member 7; Ras association (RalGDS/AF 6) domain family 7; Ras association domain containing protein 7; Ras association domain-containing protein 7; RASF7_HUMAN; RASSF 7; RASSF7;
免疫原
- Q02833 RASF7_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLLGLAAMELKVWVDGIQRVVCGVSEQTTCQEVVIALAQAIGQTGRFVLVQRLREKERQLLPQECPVGAQATCGQFASDVQFVLRRTGPSLAGRPSSDSCPPPERCLIRASLPVKPRAALGCEPRKTLTPEPAPSLSRPGPAAPVTPTPGCCTDLRGLELRVQRNAEELGHEAFWEQELRREQAREREGQARLQALSAATAEHAARLQALDAQARALEAELQLAAEAPGPPSPMASATERLHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEELNRELRQCNLQQFIQQTGAALPPPPRPDRGPPGTQGPLPPAREESLLGAPSESHAGAQPRPRGGPHDAELLEVAAAPAPEWCPLAAQPQAL
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q02833 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S97 | Phosphorylation | Uniprot | |
| K115 | Ubiquitination | Uniprot | |
| T129 | Phosphorylation | Uniprot | |
| T146 | Phosphorylation | Uniprot | |
| S232 | Phosphorylation | Uniprot | |
| T238 | Phosphorylation | Uniprot |
研究背景
Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti-apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization.
Polyubiquitinated and degraded by the proteasome upon prolonged stress stimuli.
Cytoplasm>Cytoskeleton>Microtubule organizing center>Centrosome.
Note: Colocalizes with gamma-tubulin.
Interacts with MAP2K7 and GTP-bound NRAS.
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