KCNN1 Antibody - #DF2237

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製品: KCNN1 Antibody
カタログ: DF2237
タンパク質の説明: Rabbit polyclonal antibody to KCNN1
アプリケーション: WB IF/ICC
反応性: Human, Mouse, Rat
予測: Pig, Horse, Sheep, Dog
分子量: 60 kDa; 60kD(Calculated).
ユニプロット: Q92952
RRID: AB_2839468

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製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:2000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
予測:
Pig(92%), Horse(92%), Sheep(100%), Dog(92%)
クローナリティ:
Polyclonal
特異性:
KCNN1 Antibody detects endogenous levels of total KCNN1.
RRID:
AB_2839468
引用形式: Affinity Biosciences Cat# DF2237, RRID:AB_2839468.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

hSK1; KCa2.1; KCNN 1; Kcnn1; KCNN1_HUMAN; Potassium intermediate/small conductance calcium activated channel subfamily N member 1; SK; SK1; SKCa 1; SKCa1; Small conductance calcium activated potassium channel protein 1; Small conductance calcium-activated potassium channel protein 1;

免疫原

免疫原:
Uniprot:

Q92952(KCNN1_HUMAN) >>Visit HPA database.

遺伝子(ID):
KCNN1(3780)
タンパク質の説明:
Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin
タンパク質配列:
MNSHSYNGSVGRPLGSGPGALGRDPPDPEAGHPPQPPHSPGLQVVVAKSEPARPSPGSPRGQPQDQDDDEDDEEDEAGRQRASGKPSNVGHRLGHRRALFEKRKRLSDYALIFGMFGIVVMVTETELSWGVYTKESLYSFALKCLISLSTAILLGLVVLYHAREIQLFMVDNGADDWRIAMTCERVFLISLELAVCAIHPVPGHYRFTWTARLAFTYAPSVAEADVDVLLSIPMFLRLYLLGRVMLLHSKIFTDASSRSIGALNKITFNTRFVMKTLMTICPGTVLLVFSISSWIIAAWTVRVCERYHDKQEVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKHTRLVKKPDQARVRKHQRKFLQAIHQAQKLRSVKIEQGKLNDQANTLTDLAKTQTVMYDLVSELHAQHEELEARLATLESRLDALGASLQALPGLIAQAIRPPPPPLPPRPGPGPQDQAARSSPCRWTPVAPSDCG

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Sheep
100
Pig
92
Horse
92
Dog
92
Chicken
77
Bovine
0
Xenopus
0
Zebrafish
0
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q92952 基板として

Site PTM Type Enzyme
S16 Phosphorylation
S107 Phosphorylation
Y109 Phosphorylation P00533 (EGFR)
K373 Ubiquitination
T409 Phosphorylation

研究背景

機能:

Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin (By similarity).

細胞の位置付け:

Membrane>Multi-pass membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
サブユニット構造:

Heterooligomer. The complex is composed of 4 channel subunits each of which binds to a calmodulin subunit which regulates the channel activity through calcium-binding (By similarity).

タンパク質ファミリー:

Belongs to the potassium channel KCNN family. KCa2.1/KCNN1 subfamily.

研究領域

· Organismal Systems > Endocrine system > Insulin secretion.   (View pathway)

参考文献

1). Roles of nucleus accumbens shell small-conductance calcium-activated potassium channels in the conditioned fear freezing. Journal of Psychiatric Research, 2023 (PubMed: 37216772) [IF=4.8]

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