SF3A3 Antibody - #DF2246
| 製品: | SF3A3 Antibody |
| カタログ: | DF2246 |
| タンパク質の説明: | Rabbit polyclonal antibody to SF3A3 |
| アプリケーション: | WB |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 59 kDa; 59kD(Calculated). |
| ユニプロット: | Q12874 |
| RRID: | AB_2839477 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF2246, RRID:AB_2839477.
折りたたみ／展開
SF3A3; Pre mRNA splicing factor SF3a (60kD); Pre mRNA splicing factor SF3a; PRP 9; PRP9; PRPF 9; PRPF9; SAP 61; SAP61; SF3a60; Spliceosome associated protein 61; Splicing factor 3a subunit 3 60kDa; Splicing factor 3a subunit 3;
免疫原
- Q12874 SF3A3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
METILEQQRRYHEEKERLMDVMAKEMLTKKSTLRDQINSDHRTRAMQDRYMEVSGNLRDLYDDKDGLRKEELNAISGPNEFAEFYNRLKQIKEFHRKHPNEICVPMSVEFEELLKARENPSEEAQNLVEFTDEEGYGRYLDLHDCYLKYINLKASEKLDYITYLSIFDQLFDIPKERKNAEYKRYLEMLLEYLQDYTDRVKPLQDQNELFGKIQAEFEKKWENGTFPGWPKETSSALTHAGAHLDLSAFSSWEELASLGLDRLKSALLALGLKCGGTLEERAQRLFSTKGKSLESLDTSLFAKNPKSKGTKRDTERNKDIAFLEAQIYEYVEILGEQRHLTHENVQRKQARTGEEREEEEEEQISESESEDEENEIIYNPKNLPLGWDGKPIPYWLYKLHGLNINYNCEICGNYTYRGPKAFQRHFAEWRHAHGMRCLGIPNTAHFANVTQIEDAVSLWAKLKLQKASERWQPDTEEEYEDSSGNVVNKKTYEDLKRQGLL
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q12874 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| K24 | Acetylation | Uniprot | |
| K24 | Ubiquitination | Uniprot | |
| T32 | Phosphorylation | Uniprot | |
| T43 | Phosphorylation | Uniprot | |
| R49 | Methylation | Uniprot | |
| S54 | Phosphorylation | Uniprot | |
| R58 | Methylation | Uniprot | |
| Y61 | Phosphorylation | Uniprot | |
| K64 | Ubiquitination | Uniprot | |
| K69 | Ubiquitination | Uniprot | |
| K92 | Acetylation | Uniprot | |
| K92 | Ubiquitination | Uniprot | |
| K97 | Ubiquitination | Uniprot | |
| K115 | Ubiquitination | Uniprot | |
| S121 | Phosphorylation | Uniprot | |
| T131 | Phosphorylation | Uniprot | |
| K148 | Ubiquitination | Uniprot | |
| K153 | Ubiquitination | Uniprot | |
| K201 | Ubiquitination | Uniprot | |
| K212 | Ubiquitination | Uniprot | |
| K219 | Acetylation | Uniprot | |
| S265 | Phosphorylation | Uniprot | |
| K273 | Ubiquitination | Uniprot | |
| T277 | Phosphorylation | Uniprot | |
| K291 | Ubiquitination | Uniprot | |
| S292 | Phosphorylation | Uniprot | |
| S295 | Phosphorylation | Uniprot | |
| S299 | Phosphorylation | Uniprot | |
| K303 | Ubiquitination | Uniprot | |
| T352 | Phosphorylation | Uniprot | |
| S365 | Phosphorylation | Uniprot | |
| S367 | Phosphorylation | Uniprot | |
| S369 | Phosphorylation | Uniprot | |
| Y378 | Phosphorylation | Uniprot | |
| K390 | Ubiquitination | Uniprot | |
| Y414 | Phosphorylation | Uniprot | |
| Y416 | Phosphorylation | Uniprot | |
| K420 | Ubiquitination | Uniprot | |
| K466 | Ubiquitination | Uniprot | |
| R470 | Methylation | Uniprot | |
| T475 | Phosphorylation | Uniprot | |
| Y479 | Phosphorylation | Uniprot | |
| S482 | Phosphorylation | Uniprot | |
| K489 | Acetylation | Uniprot | |
| K489 | Ubiquitination | Uniprot | |
| T491 | Phosphorylation | Uniprot | |
| Y492 | Phosphorylation | Uniprot | |
| K496 | Methylation | Uniprot | |
| K496 | Ubiquitination | Uniprot |
研究背景
Involved in pre-mRNA splicing as a component of the splicing factor SF3A complex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex. Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes.
Nucleus speckle. Nucleus.
Ubiquitous.
Component of splicing factor SF3A which is composed of three subunits; SF3A3/SAP61, SF3A2/SAP62 and SF3A1/SAP114. SF3A1 functions as scaffold that interacts directly with both SF3A2 and SF3A3. SF3A associates with the splicing factor SF3B and a 12S RNA unit to form the mature 17S U2 small nuclear ribonucleoprotein complex (17S U2 snRNP). Identified in the spliceosome 'E' complex, a precursor of the spliceosome 'A' complex. Identified in the spliceosome 'A' and 'B' complexes. Identified in the spliceosome 'C' complex.
Belongs to the SF3A3 family.
研究領域
· Genetic Information Processing > Transcription > Spliceosome.
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