GPSN2 Antibody - #DF2247
| 製品: | GPSN2 Antibody |
| カタログ: | DF2247 |
| タンパク質の説明: | Rabbit polyclonal antibody to GPSN2 |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Horse, Dog, Chicken, Xenopus |
| 分子量: | 36 kDa; 36kD(Calculated). |
| ユニプロット: | Q9NZ01 |
| RRID: | AB_2839478 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF2247, RRID:AB_2839478.
折りたたみ／展開
2410016D23Rik; A230102P12Rik; AI173355; D17Ertd178e; Glycoprotein synaptic 2; Gpsn2; Neuroprotective protein 13; SC2; Synaptic glycoprotein SC2; Tecr; TER; Trans 2,3 enoyl CoA reductase;
免疫原
- Q9NZ01 TECR_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MKHYEVEILDAKTREKLCFLDKVEPHATIAEIKNLFTKTHPQWYPARQSLRLDPKGKSLKDEDVLQKLPVGTTATLYFRDLGAQISWVTVFLTEYAGPLFIYLLFYFRVPFIYGHKYDFTSSRHTVVHLACICHSFHYIKRLLETLFVHRFSHGTMPLRNIFKNCTYYWGFAAWMAYYINHPLYTPPTYGAQQVKLALAIFVICQLGNFSIHMALRDLRPAGSKTRKIPYPTKNPFTWLFLLVSCPNYTYEVGSWIGFAIMTQCLPVALFSLVGFTQMTIWAKGKHRSYLKEFRDYPPLRMPIIPFLL
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9NZ01 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K2 | Acetylation | Uniprot | |
| K2 | Ubiquitination | Uniprot | |
| Y4 | Phosphorylation | Uniprot | |
| K12 | Acetylation | Uniprot | |
| K12 | Ubiquitination | Uniprot | |
| K16 | Ubiquitination | Uniprot | |
| K22 | Acetylation | Uniprot | |
| K22 | Ubiquitination | Uniprot | |
| T28 | Phosphorylation | Uniprot | |
| K33 | Ubiquitination | Uniprot | |
| K38 | Acetylation | Uniprot | |
| K38 | Ubiquitination | Uniprot | |
| S49 | Phosphorylation | Uniprot | |
| K57 | Ubiquitination | Uniprot | |
| S58 | Phosphorylation | Uniprot | |
| K60 | Acetylation | Uniprot | |
| K60 | Ubiquitination | Uniprot | |
| K67 | Ubiquitination | Uniprot | |
| K116 | Ubiquitination | Uniprot | |
| T145 | Phosphorylation | Uniprot | |
| K224 | Ubiquitination | Uniprot | |
| K227 | Ubiquitination | Uniprot | |
| K291 | Ubiquitination | Uniprot |
研究背景
Involved in both the production of very long-chain fatty acids for sphingolipid synthesis and the degradation of the sphingosine moiety in sphingolipids through the sphingosine 1-phosphate metabolic pathway. Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Catalyzes the saturation step of the sphingosine 1-phosphate metabolic pathway, the conversion of trans-2-hexadecenoyl-CoA to palmitoyl-CoA.
Glycosylated.
Endoplasmic reticulum membrane>Multi-pass membrane protein.
Expressed in most tissues tested. Highly expressed in skeletal muscle.
Interacts with ELOVL1 and LASS2.
Belongs to the steroid 5-alpha reductase family.
研究領域
· Metabolism > Lipid metabolism > Fatty acid elongation.
· Metabolism > Lipid metabolism > Biosynthesis of unsaturated fatty acids.
· Metabolism > Global and overview maps > Fatty acid metabolism.
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