CACNG5 Antibody - #DF2265
| 製品: | CACNG5 Antibody |
| カタログ: | DF2265 |
| タンパク質の説明: | Rabbit polyclonal antibody to CACNG5 |
| アプリケーション: | WB |
| 反応性: | Human, Mouse, Rat, Monkey |
| 予測: | Pig, Bovine, Dog, Chicken, Xenopus |
| 分子量: | 31 kDa; 31kD(Calculated). |
| ユニプロット: | Q9UF02 |
| RRID: | AB_2839494 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF2265, RRID:AB_2839494.
折りたたみ／展開
CACNG 5; Cacng5; Calcium channel voltage dependent gamma subunit 5; CCG5_HUMAN; MGC126656; MGC126682; Neuronal voltage gated calcium channel gamma 5 subunit; Neuronal voltage-gated calcium channel gamma-5 subunit; Voltage dependent calcium channel gamma 5 subunit; Voltage-dependent calcium channel gamma-5 subunit;
免疫原
- Q9UF02 CCG5_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSACGRKALTLLSSVFAVCGLGLLGIAVSTDYWLYLEEGVIVPQNQSTEIKMSLHSGLWRVCFLAGEERGRCFTIEYVMPMNTQLTSESTVNVLKMIRSATPFPLVSLFFMFIGFILNNIGHIRPHRTILAFVSGIFFILSGLSLVVGLVLYISSINDEMLNRTKDAETYFNYKYGWSFAFAAISFLLTESAGVMSVYLFMKRYTAEDMYRPHPGFYRPRLSNCSDYSGQFLHPDAWVRGRSPSDISSEASLQMNSNYPALLKCPDYDQMSSSPC
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9UF02 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y175 | Phosphorylation | Uniprot | |
| S178 | Phosphorylation | Uniprot | |
| T189 | Phosphorylation | Uniprot | |
| Y204 | Phosphorylation | Uniprot | |
| T205 | Phosphorylation | Uniprot | |
| Y210 | Phosphorylation | Uniprot | |
| Y267 | Phosphorylation | Uniprot |
研究背景
Regulates the gating properties of AMPA-selective glutamate receptors (AMPARs). Modulates their gating properties by accelerating their rates of activation, deactivation and desensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity for GRIA1, GRIA4 and the long isoform of GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity).
Membrane>Multi-pass membrane protein. Cell junction>Synapse>Postsynaptic density membrane.
The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG7 and CACNG8. Interacts with GRIA1, GRIA2, GRIA3 and GRIA4 (By similarity).
Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
研究領域
· Environmental Information Processing > Signal transduction > MAPK signaling pathway. (View pathway)
· Human Diseases > Cardiovascular diseases > Hypertrophic cardiomyopathy (HCM).
· Human Diseases > Cardiovascular diseases > Arrhythmogenic right ventricular cardiomyopathy (ARVC).
· Human Diseases > Cardiovascular diseases > Dilated cardiomyopathy (DCM).
· Organismal Systems > Circulatory system > Cardiac muscle contraction. (View pathway)
· Organismal Systems > Circulatory system > Adrenergic signaling in cardiomyocytes. (View pathway)
· Organismal Systems > Endocrine system > Oxytocin signaling pathway.
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