CCNT1 Antibody - #DF2288
| 製品: | CCNT1 Antibody |
| カタログ: | DF2288 |
| タンパク質の説明: | Rabbit polyclonal antibody to CCNT1 |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse |
| 予測: | Bovine, Horse, Sheep, Rabbit |
| 分子量: | 87 kDa; 81kD(Calculated). |
| ユニプロット: | O60563 |
| RRID: | AB_2839514 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF2288, RRID:AB_2839514.
折りたたみ／展開
CCN T1; CCNT; CCNT 1; Ccnt1; CCNT1_HUMAN; CDK9 associated C type protein; Cyc T1; Cyclin C related protein; Cyclin T; cyclin T1; Cyclin T1b; Cyclin-T; Cyclin-T1; CYCT 1; CycT1; HIVE1; Human immunodeficiency virus 1 expression; Human immunodeficiency virus type 1 (HIV 1) expression (elevated) 1; pTEFb subunit; Subunit of positive elongation transcription factor b;
免疫原
- O60563 CCNT1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O60563 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K33 | Ubiquitination | Uniprot | |
| K100 | Ubiquitination | Uniprot | |
| T110 | Phosphorylation | Uniprot | |
| S117 | Phosphorylation | Uniprot | |
| T186 | Phosphorylation | Uniprot | |
| T278 | Phosphorylation | Uniprot | |
| S279 | Phosphorylation | Uniprot | |
| T282 | Phosphorylation | Uniprot | |
| S290 | Phosphorylation | Uniprot | |
| S292 | Phosphorylation | Uniprot | |
| T307 | Phosphorylation | Uniprot | |
| S340 | Phosphorylation | Uniprot | |
| K342 | Sumoylation | Uniprot | |
| K376 | Methylation | Uniprot | |
| K376 | Ubiquitination | Uniprot | |
| K380 | Acetylation | Uniprot | |
| K386 | Acetylation | Uniprot | |
| K386 | Ubiquitination | Uniprot | |
| S388 | Phosphorylation | Uniprot | |
| K390 | Acetylation | Uniprot | |
| K390 | Methylation | Uniprot | |
| K390 | Ubiquitination | Uniprot | |
| K404 | Acetylation | Uniprot | |
| K404 | Ubiquitination | Uniprot | |
| Y418 | Phosphorylation | Uniprot | |
| Y420 | Phosphorylation | Uniprot | |
| K476 | Acetylation | Uniprot | |
| K481 | Ubiquitination | Uniprot | |
| K492 | Acetylation | Uniprot | |
| S495 | Phosphorylation | Uniprot | |
| S499 | Phosphorylation | Uniprot | |
| S529 | Phosphorylation | Uniprot | |
| S531 | Phosphorylation | Uniprot | |
| K546 | Ubiquitination | Uniprot | |
| S549 | Phosphorylation | Uniprot | |
| S564 | Phosphorylation | P53350 (PLK1) | Uniprot |
| S570 | Phosphorylation | Uniprot | |
| S577 | Phosphorylation | Uniprot | |
| K590 | Ubiquitination | Uniprot | |
| S629 | Phosphorylation | Uniprot | |
| Y690 | Phosphorylation | Uniprot | |
| K707 | Acetylation | Uniprot |
研究背景
Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II).
(Microbial infection) In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes.
Nucleus.
Ubiquitously expressed.
Cyclin-T1 is the predominant cyclin that associates with CDK9 to form a heterodimer called P-TEFb. P-TEFb forms a complex with AFF4/AF5Q31. Component of a complex which is at least composed of HTATSF1/Tat-SF1, P-TEFb complex, RNA pol II, SUPT5H, and NCL/nucleolin. Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs. Interacts with BRD4, targets chromatin binding. Interacts with JMJD6. Interacts with MDFIC. Interacts with HSF1. Interacts with HTATSF1. Interacts with AFF4. Interacts with TBX21.
(Microbial infection) Interacts with the transactivation region of HIV-1, HIV-2 and SIV Tat.
Belongs to the cyclin family. Cyclin C subfamily.
研究領域
· Human Diseases > Cancers: Overview > Transcriptional misregulation in cancer.
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