CD209 Antibody - #DF2295
| 製品: | CD209 Antibody |
| カタログ: | DF2295 |
| タンパク質の説明: | Rabbit polyclonal antibody to CD209 |
| アプリケーション: | WB |
| 反応性: | Human, Mouse |
| 予測: | Pig, Bovine, Rabbit |
| 分子量: | 44 kDa; 46kD(Calculated). |
| ユニプロット: | Q9NNX6 |
| RRID: | AB_2839521 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF2295, RRID:AB_2839521.
折りたたみ／展開
C type lectin domain family 4 member L; C-type lectin domain family 4 member L; CD 209; CD209; CD209 antigen; CD209 antigen-like protein A; CD209 molecule; CD209_HUMAN; Cd209a; CDSIGN; CIRE; CLEC4L; DC SIGN; DC SIGN1; DC-SIGN; DC-SIGN1; DCSIGN; Dendritic cell specific ICAM 3 grabbing nonintegrin 1; Dendritic cell specific ICAM3 grabbing nonintegrin 1; Dendritic cell-specific ICAM-3-grabbing non-integrin 1; Dendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbing non-integrin; Dengue fever, protection against, included; Dentritic Cell Specific ICAM3 Grabbing Nonintegrin; HIV GP120 Binding Protein; MGC129965; MGC130443; SIGN-R1; SIGNR5;
免疫原
Predominantly expressed in dendritic cells and in DC-residing tissues. Also found in placental macrophages, endothelial cells of placental vascular channels, peripheral blood mononuclear cells, and THP-1 monocytes.
- Q9NNX6 CD209_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSDSKEPRLQQLGLLEEEQLRGLGFRQTRGYKSLAGCLGHGPLVLQLLSFTLLAGLLVQVSKVPSSISQEQSRQDAIYQNLTQLKAAVGELSEKSKLQEIYQELTQLKAAVGELPEKSKLQEIYQELTRLKAAVGELPEKSKLQEIYQELTWLKAAVGELPEKSKMQEIYQELTRLKAAVGELPEKSKQQEIYQELTRLKAAVGELPEKSKQQEIYQELTRLKAAVGELPEKSKQQEIYQELTQLKAAVERLCHPCPWEWTFFQGNCYFMSNSQRNWHDSITACKEVGAQLVVIKSAEEQNFLQLQSSRSNRFTWMGLSDLNQEGTWQWVDGSPLLPSFKQYWNRGEPNNVGEEDCAEFSGNGWNDDKCNLAKFWICKKSAASCSRDEEQFLSPAPATPNPPPA
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9NNX6 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y101 | Phosphorylation | Uniprot | |
| K108 | Acetylation | Uniprot | |
| S118 | Phosphorylation | Uniprot | |
| K131 | Acetylation | Uniprot | |
| S141 | Phosphorylation | Uniprot | |
| K154 | Acetylation | Uniprot | |
| S164 | Phosphorylation | Uniprot | |
| K177 | Acetylation | Uniprot | |
| S187 | Phosphorylation | Uniprot | |
| K200 | Acetylation | Uniprot | |
| S210 | Phosphorylation | Uniprot | |
| K223 | Acetylation | Uniprot | |
| S233 | Phosphorylation | Uniprot | |
| Y239 | Phosphorylation | Uniprot | |
| S338 | Phosphorylation | Uniprot |
研究背景
Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response.
On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells.
(Microbial infection) Acts as an attachment receptor for HIV-1 and HIV-2.
(Microbial infection) Acts as an attachment receptor for Ebolavirus.
(Microbial infection) Acts as an attachment receptor for Cytomegalovirus.
(Microbial infection) Acts as an attachment receptor for HCV.
(Microbial infection) Acts as an attachment receptor for Dengue virus.
(Microbial infection) Acts as an attachment receptor for Measles virus.
(Microbial infection) Acts as an attachment receptor for Herpes simplex virus 1.
(Microbial infection) Acts as an attachment receptor for Influenzavirus A.
(Microbial infection) Acts as an attachment receptor for SARS coronavirus.
(Microbial infection) Acts as an attachment receptor for Japanese encephalitis virus.
(Microbial infection) Acts as an attachment receptor for Lassa virus. Acts as an attachment receptor for Marburg virusn.
(Microbial infection) Acts as an attachment receptor for Respiratory syncytial virus.
(Microbial infection) Acts as an attachment receptor for Rift valley fever virus and uukuniemi virus.
(Microbial infection) Acts as an attachment receptor for West-nile virus.
(Microbial infection) Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of bacterial pathogen antigens, including Leishmania pifanoi LPG, Lewis-x antigen in Helicobacter pylori LPS, mannose in Klebsiella pneumonae LPS, di-mannose and tri-mannose in Mycobacterium tuberculosis ManLAM and Lewis-x antigen in Schistosoma mansoni SEA. Recognition of M.tuberculosis by dendritic cells occurs partially via this molecule.
Cell membrane>Single-pass type II membrane protein.
Cell membrane>Single-pass type II membrane protein.
Cell membrane>Single-pass type II membrane protein.
Cell membrane>Single-pass type II membrane protein.
Cell membrane>Single-pass type II membrane protein.
Secreted.
Secreted.
Secreted.
Secreted.
Secreted.
Secreted.
Secreted.
Predominantly expressed in dendritic cells and in DC-residing tissues. Also found in placental macrophages, endothelial cells of placental vascular channels, peripheral blood mononuclear cells, and THP-1 monocytes.
Homotetramer. Interacts with C1QBP; the interaction is indicative for a C1q:C1QBP:CD209 signaling complex. Interacts with ICAM2 and ICAM3 by binding to mannose-like carbohydrates. Interacts (via C-type lectin domain) with CEACAM1 (via Lewis X moieties); this interaction is regulated by the glycosylation pattern of CEACAM1 on cell types and regulates contact between dendritic cells and neutrophils.
(Microbial infection) Interacts with HIV-1 and HIV-2 gp120.
(Microbial infection) Interacts with ebolavirus envelope glycoproteins.
(Microbial infection) Interacts with cytomegalovirus gB protein.
(Microbial infection) Interacts with HCV E2 protein.
(Microbial infection) Interacts with dengue virus major envelope protein E.
(Microbial infection) Interacts with measles hemagglutinin.
(Microbial infection) Interacts with herpes simplex virus 1 surface proteins.
(Microbial infection) Interacts with Influenzavirus A hemagglutinin.
(Microbial infection) Interacts with SARS coronavirus glycoprotein.
(Microbial infection) Interacts with Japanese encephalitis virus E protein.
(Microbial infection) Interacts with Lassa virus Glycoprotein.
(Microbial infection) Interacts with marburg virus glycoprotein.
(Microbial infection) Interacts with Respiratory syncytial virus glycoprotein G.
(Microbial infection) Interacts with Rift valley fever virus and uukuniemi virus envelope glycoprotein.
(Microbial infection) Interacts with west-nile virus envelope glycoprotein.
(Microbial infection) Interacts with whole M.bovis cells in a Ca(2+)-dependent and independent manner; in vitro experiments suggest it interacts with CH60.1 (groL1), DnaK, GADPH (gap) and LrpG.
The tandem repeat domain, also called neck domain, mediates oligomerization.
研究領域
· Cellular Processes > Transport and catabolism > Phagosome. (View pathway)
· Human Diseases > Infectious diseases: Bacterial > Tuberculosis.
· Human Diseases > Infectious diseases: Viral > Measles.
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.