CENPI Antibody - #DF2311
| 製品: | CENPI Antibody |
| カタログ: | DF2311 |
| タンパク質の説明: | Rabbit polyclonal antibody to CENPI |
| アプリケーション: | WB IHC |
| 反応性: | Human |
| 分子量: | 87 kDa; 87kD(Calculated). |
| ユニプロット: | Q92674 |
| RRID: | AB_2839535 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF2311, RRID:AB_2839535.
折りたたみ／展開
CENP I; centromere protein I; Follicle simulating hormone primary response protein; FSH primary response 1; FSH primary response protein 1; FSH primary response, rat, homolog of, 1; FSHP1; FSHPRH1; interphase centromere complex protein 19; Leucine rich primary response gene 1; Leucine rich primary response protein 1; LRPR1; Mis6;
免疫原
- Q92674 CENPI_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSPQKRVKNVQAQNRTSQGSSSFQTTLSAWKVKQDPSNSKNISKHGQNNPVGDYEHADDQAEEDALQMAVGYFEKGPIKASQNKDKTLEKHLKTVENVAWKNGLASEEIDILLNIALSGKFGNAVNTRILKCMIPATVISEDSVVKAVSWLCVGKCSGSTKVLFYRWLVAMFDFIDRKEQINLLYGFFFASLQDDALCPYVCHLLYLLTKKENVKPFRVRKLLDLQAKMGMQPHLQALLSLYKFFAPALISVSLPVRKKIYFKNSENLWKTALLAVKQRNRGPSPEPLKLMLGPANVRPLKRKWNSLSVIPVLNSSSYTKECGKKEMSLSDCLNRSGSFPLEQLQSFPQLLQNIHCLELPSQMGSVLNNSLLLHYINCVRDEPVLLRFYYWLSQTLQEECIWYKVNNYEHGKEFTNFLDTIIRAECFLQEGFYSCEAFLYKSLPLWDGLCCRSQFLQLVSWIPFSSFSEVKPLLFDHLAQLFFTSTIYFKCSVLQSLKELLQNWLLWLSMDIHMKPVTNSPLETTLGGSMNSVSKLIHYVGWLSTTAMRLESNNTFLLHFILDFYEKVCDIYINYNLPLVVLFPPGIFYSALLSLDTSILNQLCFIMHRYRKNLTAAKKNELVQKTKSEFNFSSKTYQEFNHYLTSMVGCLWTSKPFGKGIYIDPEILEKTGVAEYKNSLNVVHHPSFLSYAVSFLLQESPEERTVNVSSIRGKKWSWYLDYLFSQGLQGLKLFIRSSVHHSSIPRAEGINCNNQY
PTMs - Q92674 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T16 | Phosphorylation | Uniprot | |
| S17 | Phosphorylation | Uniprot | |
| S22 | Phosphorylation | Uniprot | |
| T25 | Phosphorylation | Uniprot | |
| K93 | Ubiquitination | Uniprot | |
| K221 | Ubiquitination | Uniprot | |
| K270 | Ubiquitination | Uniprot | |
| K277 | Ubiquitination | Uniprot | |
| S284 | Phosphorylation | Uniprot | |
| K301 | Ubiquitination | Uniprot | |
| S306 | Phosphorylation | Uniprot | |
| S308 | Phosphorylation | Uniprot | |
| S316 | Phosphorylation | Uniprot | |
| Y318 | Phosphorylation | Uniprot | |
| K325 | Ubiquitination | Uniprot | |
| T420 | Phosphorylation | Uniprot | |
| S492 | Phosphorylation | Uniprot | |
| S520 | Phosphorylation | Uniprot | |
| K619 | Ubiquitination | Uniprot | |
| K625 | Ubiquitination | Uniprot | |
| K627 | Ubiquitination | Uniprot | |
| Y637 | Phosphorylation | Uniprot | |
| H642 | Phosphorylation | Uniprot | |
| Y643 | Phosphorylation | Uniprot | |
| K659 | Ubiquitination | Uniprot | |
| K670 | Ubiquitination | Uniprot | |
| T705 | Phosphorylation | Uniprot | |
| S709 | Phosphorylation | Uniprot |
研究背景
Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Required for the localization of CENPF, MAD1L1 and MAD2 (MAD2L1 or MAD2L2) to kinetochores. Involved in the response of gonadal tissues to follicle-stimulating hormone.
Sumoylated. Sumoylated form can be polyubiquitinated by RNF4, leading to its degradation. Desumoylation by SENP6 prevents its degradation.
Nucleus. Chromosome>Centromere.
Note: Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.
Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. Interacts with SENP6.
Belongs to the CENP-I/CTF3 family.
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