MSH3 Antibody - #DF2385
| 製品: | MSH3 Antibody |
| カタログ: | DF2385 |
| タンパク質の説明: | Rabbit polyclonal antibody to MSH3 |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Horse, Sheep, Rabbit, Dog |
| 分子量: | 127 kDa; 127kD(Calculated). |
| ユニプロット: | P20585 |
| RRID: | AB_2839593 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF2385, RRID:AB_2839593.
折りたたみ／展開
Divergent upstream protein; DNA mismatch repair protein; DNA mismatch repair protein Msh 3; DNA mismatch repair protein MSH3; DUC 1; DUC1; DUG; DUP; hMSH3; MGC163306; MGC163308; Mismatch repair protein 1; MRP 1; MRP1; MSH 3; MSH3; MSH3_HUMAN; MutS homolog 3 (E. coli); MutS homolog 3;
免疫原
- P20585 MSH3_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSRRKPASGGLAASSSAPARQAVLSRFFQSTGSLKSTSSSTGAADQVDPGAAAAAAAAAAAAPPAPPAPAFPPQLPPHIATEIDRRKKRPLENDGPVKKKVKKVQQKEGGSDLGMSGNSEPKKCLRTRNVSKSLEKLKEFCCDSALPQSRVQTESLQERFAVLPKCTDFDDISLLHAKNAVSSEDSKRQINQKDTTLFDLSQFGSSNTSHENLQKTASKSANKRSKSIYTPLELQYIEMKQQHKDAVLCVECGYKYRFFGEDAEIAARELNIYCHLDHNFMTASIPTHRLFVHVRRLVAKGYKVGVVKQTETAALKAIGDNRSSLFSRKLTALYTKSTLIGEDVNPLIKLDDAVNVDEIMTDTSTSYLLCISENKENVRDKKKGNIFIGIVGVQPATGEVVFDSFQDSASRSELETRMSSLQPVELLLPSALSEQTEALIHRATSVSVQDDRIRVERMDNIYFEYSHAFQAVTEFYAKDTVDIKGSQIISGIVNLEKPVICSLAAIIKYLKEFNLEKMLSKPENFKQLSSKMEFMTINGTTLRNLEILQNQTDMKTKGSLLWVLDHTKTSFGRRKLKKWVTQPLLKLREINARLDAVSEVLHSESSVFGQIENHLRKLPDIERGLCSIYHKKCSTQEFFLIVKTLYHLKSEFQAIIPAVNSHIQSDLLRTVILEIPELLSPVEHYLKILNEQAAKVGDKTELFKDLSDFPLIKKRKDEIQGVIDEIRMHLQEIRKILKNPSAQYVTVSGQEFMIEIKNSAVSCIPTDWVKVGSTKAVSRFHSPFIVENYRHLNQLREQLVLDCSAEWLDFLEKFSEHYHSLCKAVHHLATVDCIFSLAKVAKQGDYCRPTVQEERKIVIKNGRHPVIDVLLGEQDQYVPNNTDLSEDSERVMIITGPNMGGKSSYIKQVALITIMAQIGSYVPAEEATIGIVDGIFTRMGAADNIYKGQSTFMEELTDTAEIIRKATSQSLVILDELGRGTSTHDGIAIAYATLEYFIRDVKSLTLFVTHYPPVCELEKNYSHQVGNYHMGFLVSEDESKLDPGAAEQVPDFVTFLYQITRGIAARSYGLNVAKLADVPGEILKKAAHKSKELEGLINTKRKRLKYFAKLWTMHNAQDLQKWTEEFNMEETQTSLLH
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P20585 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S14 | Phosphorylation | Uniprot | |
| S16 | Phosphorylation | Uniprot | |
| S30 | Phosphorylation | Uniprot | |
| S33 | Phosphorylation | Uniprot | |
| K103 | Acetylation | Uniprot | |
| K107 | Ubiquitination | Uniprot | |
| S111 | Phosphorylation | Uniprot | |
| S116 | Phosphorylation | Uniprot | |
| K165 | Ubiquitination | Uniprot | |
| K178 | Ubiquitination | Uniprot | |
| K193 | Ubiquitination | Uniprot | |
| S201 | Phosphorylation | Uniprot | |
| K215 | Ubiquitination | Uniprot | |
| Y229 | Phosphorylation | Uniprot | |
| Y236 | Phosphorylation | Uniprot | |
| K240 | Ubiquitination | Uniprot | |
| K308 | Ubiquitination | Uniprot | |
| K316 | Methylation | Uniprot | |
| K316 | Ubiquitination | Uniprot | |
| S337 | Phosphorylation | Uniprot | |
| T338 | Phosphorylation | Uniprot | |
| S520 | Phosphorylation | Uniprot | |
| T540 | Phosphorylation | Uniprot | |
| T541 | Phosphorylation | Uniprot | |
| K557 | Sumoylation | Uniprot | |
| K586 | Ubiquitination | Uniprot | |
| K695 | Ubiquitination | Uniprot | |
| K704 | Ubiquitination | Uniprot | |
| K713 | Ubiquitination | Uniprot | |
| K770 | Ubiquitination | Uniprot | |
| K775 | Ubiquitination | Uniprot | |
| K842 | Ubiquitination | Uniprot | |
| K902 | Ubiquitination | Uniprot | |
| T967 | Phosphorylation | Uniprot | |
| S968 | Phosphorylation | Uniprot | |
| T1054 | Phosphorylation | Uniprot | |
| Y1068 | Phosphorylation | Uniprot | |
| K1074 | Ubiquitination | Uniprot | |
| K1091 | Ubiquitination | Uniprot | |
| T1099 | Phosphorylation | Uniprot | |
| K1100 | Ubiquitination | Uniprot |
研究背景
Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.
Component of the DNA mismatch repair (MMR) complex composed at least of MSH2, MSH3, MSH6, PMS1 and MLH1. Heterodimer consisting of MSH2-MSH3 (MutS beta). Forms a ternary complex with MutL alpha (MLH1-PMS1). Interacts with EXO1. Interacts with MCM9.
Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.
研究領域
· Genetic Information Processing > Replication and repair > Mismatch repair.
· Human Diseases > Drug resistance: Antineoplastic > Platinum drug resistance.
· Human Diseases > Cancers: Overview > Pathways in cancer. (View pathway)
· Human Diseases > Cancers: Specific types > Colorectal cancer. (View pathway)
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