RB6I2 Antibody - #DF2426
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| 製品: | RB6I2 Antibody |
| カタログ: | DF2426 |
| タンパク質の説明: | Rabbit polyclonal antibody to RB6I2 |
| アプリケーション: | WB |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| 分子量: | 128kDa; 128kD(Calculated). |
| ユニプロット: | Q8IUD2 |
| RRID: | AB_2839632 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF2426, RRID:AB_2839632.
折りたたみ／展開
Cast 2; CAST2; CAZ associated structural protein 2; Elks; ELKS/RAB6 interacting/CAST family member 1; ELKS/RAB6-interacting/CAST family member 1; ERC 1; ERC protein 1; ERC-1; Erc1; ERC1 protein; KIAA1081; MGC12974; RAB6 interacting protein 2; RAB6-interacting protein 2; RAB6IP2; RB6I2_HUMAN;
免疫原
Widely expressed. Isoform 2 and isoform 4 are abundantly expressed in brain. Isoform 1 and isoform 3 are predominantly expressed in testis and thyroid, and isoform 1 predominates in other tissues tested.
- Q8IUD2 RB6I2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHENVGSETPKSTMTLGRSGGRLPYGVRMTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQAAWENELQKMTRGQLQDELEKGERDNAELQEFANAILQQIADHCPDILEQVVNALEESS
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q8IUD2 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y2 | Phosphorylation | Uniprot | |
| S4 | Phosphorylation | Uniprot | |
| R6 | Methylation | Uniprot | |
| S7 | Phosphorylation | Uniprot | |
| K10 | Acetylation | Uniprot | |
| S14 | Phosphorylation | Uniprot | |
| S15 | Phosphorylation | Uniprot | |
| S17 | Phosphorylation | Uniprot | |
| R20 | Methylation | Uniprot | |
| S21 | Phosphorylation | Uniprot | |
| S27 | Phosphorylation | Uniprot | |
| T35 | Phosphorylation | Uniprot | |
| S37 | Phosphorylation | Uniprot | |
| T38 | Phosphorylation | Uniprot | |
| S41 | Phosphorylation | Uniprot | |
| T53 | Phosphorylation | Uniprot | |
| S55 | Phosphorylation | Uniprot | |
| Y73 | Phosphorylation | Uniprot | |
| S75 | Phosphorylation | Uniprot | |
| R93 | Methylation | Uniprot | |
| S94 | Phosphorylation | Uniprot | |
| S181 | Phosphorylation | Uniprot | |
| S191 | Phosphorylation | Uniprot | |
| S250 | Phosphorylation | Uniprot | |
| C258 | S-Nitrosylation | Uniprot | |
| K299 | Ubiquitination | Uniprot | |
| S374 | Phosphorylation | Uniprot | |
| K488 | Ubiquitination | Uniprot | |
| K552 | Ubiquitination | Uniprot | |
| K590 | Acetylation | Uniprot | |
| K602 | Ubiquitination | Uniprot | |
| S603 | Phosphorylation | Uniprot | |
| K625 | Ubiquitination | Uniprot | |
| K652 | Acetylation | Uniprot | |
| K655 | Acetylation | Uniprot | |
| K658 | Acetylation | Uniprot | |
| K671 | Ubiquitination | Uniprot | |
| S674 | Phosphorylation | Uniprot | |
| K679 | Ubiquitination | Uniprot | |
| S688 | Phosphorylation | Uniprot | |
| K691 | Ubiquitination | Uniprot | |
| K719 | Ubiquitination | Uniprot | |
| S730 | Phosphorylation | Uniprot | |
| R736 | Methylation | Uniprot | |
| K766 | Ubiquitination | Uniprot | |
| K799 | Acetylation | Uniprot | |
| K805 | Acetylation | Uniprot | |
| S807 | Phosphorylation | Uniprot | |
| S824 | Phosphorylation | Uniprot | |
| K835 | Ubiquitination | Uniprot | |
| K894 | Ubiquitination | Uniprot | |
| S901 | Phosphorylation | Uniprot | |
| K905 | Ubiquitination | Uniprot | |
| K973 | Ubiquitination | Uniprot | |
| Y987 | Phosphorylation | Uniprot | |
| K1003 | Ubiquitination | Uniprot | |
| S1005 | Phosphorylation | Uniprot | |
| T1046 | Phosphorylation | Uniprot | |
| S1050 | Phosphorylation | Uniprot | |
| Y1051 | Phosphorylation | Uniprot | |
| K1066 | Ubiquitination | Uniprot |
研究背景
Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport.
Cytoplasm>Cytoskeleton>Microtubule organizing center>Centrosome. Cytoplasm. Membrane>Peripheral membrane protein. Golgi apparatus membrane>Peripheral membrane protein. Cell junction>Synapse>Presynaptic cell membrane.
Note: Recruited on Golgi membranes by RAB6A in a GTP-dependent manner (By similarity).
Widely expressed. Isoform 2 and isoform 4 are abundantly expressed in brain. Isoform 1 and isoform 3 are predominantly expressed in testis and thyroid, and isoform 1 predominates in other tissues tested.
Part of a complex with CHUK, IKBKB and IKBKG. Interacts with CHUK, IKBKB and IKBKG. The interaction with IKBKG is independent of CHUK and IKBKB. Interacts with NFKBIA. Isoform 4 interacts with PPFIA1, and through its C-terminus with the PDZ domains of RIMS1 and RIMS2. Interacts with ERC2/CAST1. Interacts with the GTB-bound forms of RAB6A isoform 1 and isoform 2 and with RAB6B. The interaction was strongest with RAB6B, followed by RAB6A isoform 2 and weakest with RAB6A isoform 1 (By similarity). Interacts with SDCCAG8.
研究領域
· Environmental Information Processing > Signal transduction > NF-kappa B signaling pathway. (View pathway)
参考文献
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