ZFPM1 Antibody - #DF2428
| 製品: | ZFPM1 Antibody |
| カタログ: | DF2428 |
| タンパク質の説明: | Rabbit polyclonal antibody to ZFPM1 |
| アプリケーション: | WB |
| 反応性: | Human, Mouse |
| 予測: | Pig |
| 分子量: | 104 kDa; 105kD(Calculated). |
| ユニプロット: | Q8IX07 |
| RRID: | AB_2839634 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF2428, RRID:AB_2839634.
折りたたみ／展開
FOG-1; FOG1_HUMAN; Friend of GATA 1; Friend of GATA protein 1; Friend of GATA1; ZFPM1; Zinc finger protein; Zinc finger protein 89A; Zinc finger protein multitype 1; Zinc finger protein ZFPM1;
免疫原
Mainly expressed in hematopoietic tissues. Also expressed in adult cerebellum, stomach, lymph node, liver and pancreas. Expressed in fetal heart, liver and spleen.
- Q8IX07 FOG1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSRRKQSNPRQIKRSLGDMEAREEVQLVGASHMEQKATAPEAPSPPSADVNSPPPLPPPTSPGGPKELEGQEPEPRPTEEEPGSPWSGPDELEPVVQDGQRRIRARLSLATGLSWGPFHGSVQTRASSPRQAEPSPALTLLLVDEACWLRTLPQALTEAEANTEIHRKDDALWCRVTKPVPAGGLLSVLLTAEPHSTPGHPVKKEPAEPTCPAPAHDLQLLPQQAGMASILATAVINKDVFPCKDCGIWYRSERNLQAHLLYYCASRQGTGSPAAAATDEKPKETYPNERVCPFPQCRKSCPSASSLEIHMRSHSGERPFVCLICLSAFTTKANCERHLKVHTDTLSGVCHSCGFISTTRDILYSHLVTNHMVCQPGSKGEIYSPGAGHPATKLPPDSLGSFQQQHTALQGPLASADLGLAPTPSPGLDRKALAEATNGEARAEPLAQNGGSSEPPAAPRSIKVEAVEEPEAAPILGPGEPGPQAPSRTPSPRSPAPARVKAELSSPTPGSSPVPGELGLAGALFLPQYVFGPDAAPPASEILAKMSELVHSRLQQGAGAGAGGAQTGLFPGAPKGATCFECEITFSNVNNYYVHKRLYCSGRRAPEDAPAARRPKAPPGPARAPPGQPAEPDAPRSSPGPGAREEGAGGAATPEDGAGGRGSEGSQSPGSSVDDAEDDPSRTLCEACNIRFSRHETYTVHKRYYCASRHDPPPRRPAAPPGPPGPAAPPAPSPAAPVRTRRRRKLYELHAAGAPPPPPPGHAPAPESPRPGSGSGSGPGLAPARSPGPAADGPIDLSKKPRRPLPGAPAPALADYHECTACRVSFHSLEAYLAHKKYSCPAAPPPGALGLPAAACPYCPPNGPVRGDLLEHFRLAHGLLLGAPLAGPGVEARTPADRGPSPAPAPAASPQPGSRGPRDGLGPEPQEPPPGPPPSPAAAPEAVPPPPAPPSYSDKGVQTPSKGTPAPLPNGNHRYCRLCNIKFSSLSTFIAHKKYYCSSHAAEHVK
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q8IX07 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S15 | Phosphorylation | Uniprot | |
| S44 | Phosphorylation | Uniprot | |
| S47 | Phosphorylation | Uniprot | |
| S52 | Phosphorylation | Uniprot | |
| S84 | Phosphorylation | Uniprot | |
| S87 | Phosphorylation | Uniprot | |
| Y262 | Phosphorylation | Uniprot | |
| S266 | Phosphorylation | Uniprot | |
| T270 | Phosphorylation | Uniprot | |
| S272 | Phosphorylation | Uniprot | |
| T278 | Phosphorylation | Uniprot | |
| Y383 | Phosphorylation | Uniprot | |
| S384 | Phosphorylation | Uniprot | |
| K463 | Sumoylation | Uniprot | |
| S487 | Phosphorylation | Uniprot | |
| T489 | Phosphorylation | Uniprot | |
| S491 | Phosphorylation | Uniprot | |
| S494 | Phosphorylation | Uniprot | |
| K501 | Sumoylation | Uniprot | |
| S638 | Phosphorylation | Uniprot | |
| T653 | Phosphorylation | Uniprot | |
| S666 | Phosphorylation | Uniprot | |
| S668 | Phosphorylation | Uniprot | |
| S671 | Phosphorylation | Uniprot | |
| S681 | Phosphorylation | Uniprot | |
| Y698 | Phosphorylation | Uniprot | |
| T699 | Phosphorylation | Uniprot | |
| Y704 | Phosphorylation | Uniprot | |
| S708 | Phosphorylation | Uniprot | |
| S733 | Phosphorylation | Uniprot | |
| S768 | Phosphorylation | Uniprot | |
| S773 | Phosphorylation | Uniprot | |
| S786 | Phosphorylation | Uniprot | |
| S798 | Phosphorylation | Uniprot | |
| T894 | Phosphorylation | Uniprot | |
| S901 | Phosphorylation | Uniprot | |
| S909 | Phosphorylation | Uniprot | |
| S914 | Phosphorylation | Uniprot | |
| S935 | Phosphorylation | Uniprot |
研究背景
Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of some genes in gonads. May also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2 (By similarity).
Nucleus.
Mainly expressed in hematopoietic tissues. Also expressed in adult cerebellum, stomach, lymph node, liver and pancreas. Expressed in fetal heart, liver and spleen.
Interacts with corepressor CTBP2; this interaction is however not essential for corepressor activity (By similarity). Interacts with the N-terminal zinc-finger of GATA1, GATA2 and probably GATA3.
The CCHC FOG-type zinc fingers 1, 2, 3 and 5 directly bind to GATA-type zinc fingers. The Tyr residue adjacent to the last Cys of the CCHC FOG-type zinc finger is essential for the interaction with GATA-type zinc fingers (By similarity).
Belongs to the FOG (Friend of GATA) family.
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