TSYL2 Antibody - #DF2466
| 製品: | TSYL2 Antibody |
| カタログ: | DF2466 |
| タンパク質の説明: | Rabbit polyclonal antibody to TSYL2 |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 分子量: | 79kDa; 79kD(Calculated). |
| ユニプロット: | Q9H2G4 |
| RRID: | AB_2839672 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF2466, RRID:AB_2839672.
折りたたみ／展開
CASK interacting nucleosome assembly protein; CDA1; Cell division autoantigen 1; CINAP; CTCL; CTCL tumor antigen se20 4; CTCL-associated antigen se20-4; Cutaneous T cell lymphoma associated antigen se20 4; Cutaneous T cell lymphoma associated tumor antigen se20 4; Cutaneous T-cell lymphoma-associated antigen se20-4; Differentially Expressed Nucleolar TGF beta1 Target; Differentially Expressed Nucleolar TGF beta1 Target protein; Differentially-expressed nucleolar TGF-beta1 target protein; HRIHFB2216; NP79; Nuclear protein of 79 kDa; RP1 290F12.2; SE20 4; SE204; Testis specific protein Y encoded like 2; testis-specific protein Y encoded-like 2; Testis-specific Y-encoded-like protein 2; TSPX; TSPY like 2; TSPY like protein 2; TSPY-like protein 2; TSPYL2; TSYL2_HUMAN;
免疫原
Ubiquitously expressed, with highest levels in brain, testis and heart, and lowest levels in liver and pancreas.
- Q9H2G4 TSYL2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDRPDEGPPAKTRRLSSSESPQRDPPPPPPPPPLLRLPLPPPQQRPRLQEETEAAQVLADMRGVGLGPALPPPPPYVILEEGGIRAYFTLGAECPGWDSTIESGYGEAPPPTESLEALPTPEASGGSLEIDFQVVQSSSFGGEGALETCSAVGWAPQRLVDPKSKEEAIIIVEDEDEDERESMRSSRRRRRRRRRKQRKVKRESRERNAERMESILQALEDIQLDLEAVNIKAGKAFLRLKRKFIQMRRPFLERRDLIIQHIPGFWVKAFLNHPRISILINRRDEDIFRYLTNLQVQDLRHISMGYKMKLYFQTNPYFTNMVIVKEFQRNRSGRLVSHSTPIRWHRGQEPQARRHGNQDASHSFFSWFSNHSLPEADRIAEIIKNDLWVNPLRYYLRERGSRIKRKKQEMKKRKTRGRCEVVIMEDAPDYYAVEDIFSEISDIDETIHDIKISDFMETTDYFETTDNEITDINENICDSENPDHNEVPNNETTDNNESADDHETTDNNESADDNNENPEDNNKNTDDNEENPNNNENTYGNNFFKGGFWGSHGNNQDSSDSDNEADEASDDEDNDGNEGDNEGSDDDGNEGDNEGSDDDDRDIEYYEKVIEDFDKDQADYEDVIEIISDESVEEEGIEEGIQQDEDIYEEGNYEEEGSEDVWEEGEDSDDSDLEDVLQVPNGWANPGKRGKTG
PTMs - Q9H2G4 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K11 | Ubiquitination | Uniprot | |
| S16 | Phosphorylation | Uniprot | |
| S17 | Phosphorylation | Uniprot | |
| S18 | Phosphorylation | Uniprot | |
| S20 | Phosphorylation | P24941 (CDK2) | Uniprot |
| S182 | Phosphorylation | Uniprot | |
| K235 | Ubiquitination | Uniprot | |
| S303 | Phosphorylation | Uniprot | |
| Y306 | Phosphorylation | Uniprot | |
| Y311 | Phosphorylation | Uniprot | |
| S339 | Phosphorylation | Uniprot | |
| T340 | Phosphorylation | P24941 (CDK2) | Uniprot |
| K384 | Ubiquitination | Uniprot | |
| K407 | Methylation | Uniprot | |
| K414 | Acetylation | Uniprot |
研究背景
Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression.
Phosphorylation at Ser-20 and/or Thr-340 impairs function on cell proliferation.
Nucleus. Cytoplasm.
Note: Enriched in transcriptionally active regions of chromatin in neurons.
Ubiquitously expressed, with highest levels in brain, testis and heart, and lowest levels in liver and pancreas.
Interacts with histones. Interacts with CASK. Part of a complex containing CASK, TBR1 and TSPYL2 (By similarity).
Belongs to the nucleosome assembly protein (NAP) family.
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