K2C1 Antibody - #DF2554
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF2554, RRID:AB_2839760.
折りたたみ／展開
67 kDa cytokeratin; CK-1; CK1; Cytokeratin 1; Cytokeratin 19; Cytokeratin 8; Cytokeratin-1; EHK; EHK1; epidermolytic hyperkeratosis 1; EPPK; Hair alpha protein; K1; K2C1_HUMAN; KB1; Keratin 1; keratin 1, type II; Keratin 19; Keratin 8; Keratin; keratin, type II cytoskeletal 1; Keratin-1; Krt1; KRT19; KRT1A; KRT8; KRTA; NEPPK; type II cytoskeletal 1; Type-II keratin Kb1;
免疫原
The source of this protein is neonatal foreskin. The 67-kDa type II keratins are expressed in terminally differentiating epidermis.
- P04264 K2C1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSRQFSSRSGYRSGGGFSSGSAGIINYQRRTTSSSTRRSGGGGGRFSSCGGGGGSFGAGGGFGSRSLVNLGGSKSISISVARGGGRGSGFGGGYGGGGFGGGGFGGGGFGGGGIGGGGFGGFGSGGGGFGGGGFGGGGYGGGYGPVCPPGGIQEVTINQSLLQPLNVEIDPEIQKVKSREREQIKSLNNQFASFIDKVRFLEQQNQVLQTKWELLQQVDTSTRTHNLEPYFESFINNLRRRVDQLKSDQSRLDSELKNMQDMVEDYRNKYEDEINKRTNAENEFVTIKKDVDGAYMTKVDLQAKLDNLQQEIDFLTALYQAELSQMQTQISETNVILSMDNNRSLDLDSIIAEVKAQYEDIAQKSKAEAESLYQSKYEELQITAGRHGDSVRNSKIEISELNRVIQRLRSEIDNVKKQISNLQQSISDAEQRGENALKDAKNKLNDLEDALQQAKEDLARLLRDYQELMNTKLALDLEIATYRTLLEGEESRMSGECAPNVSVSVSTSHTTISGGGSRGGGGGGYGSGGSSYGSGGGSYGSGGGGGGGRGSYGSGGSSYGSGGGSYGSGGGGGGHGSYGSGSSSGGYRGGSGGGGGGSSGGRGSGGGSSGGSIGGRGSSSGGVKSSGGSSSVKFVSTTYSGVTR
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P04264 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S13 | Phosphorylation | Uniprot | |
| S21 | Phosphorylation | Uniprot | |
| Y27 | Phosphorylation | Uniprot | |
| T31 | Phosphorylation | Uniprot | |
| S47 | Phosphorylation | Uniprot | |
| S48 | Phosphorylation | Uniprot | |
| S66 | Phosphorylation | Uniprot | |
| R82 | Methylation | Uniprot | |
| S193 | Phosphorylation | Uniprot | |
| K197 | Acetylation | Uniprot | |
| K197 | Ubiquitination | Uniprot | |
| K211 | Methylation | Uniprot | |
| S233 | Phosphorylation | Uniprot | |
| S254 | Phosphorylation | Uniprot | |
| K269 | Methylation | Uniprot | |
| K269 | Ubiquitination | Uniprot | |
| Y270 | Phosphorylation | Uniprot | |
| K276 | Methylation | Uniprot | |
| K276 | Ubiquitination | Uniprot | |
| Y295 | Phosphorylation | Uniprot | |
| T297 | Phosphorylation | Uniprot | |
| K298 | Acetylation | Uniprot | |
| S344 | Phosphorylation | Uniprot | |
| K355 | Ubiquitination | Uniprot | |
| Y358 | Phosphorylation | Uniprot | |
| K364 | Ubiquitination | Uniprot | |
| K366 | Ubiquitination | Uniprot | |
| S371 | Phosphorylation | Uniprot | |
| Y373 | Phosphorylation | Uniprot | |
| Y377 | Phosphorylation | Uniprot | |
| T383 | Phosphorylation | Uniprot | |
| S394 | Phosphorylation | Uniprot | |
| K395 | Ubiquitination | Uniprot | |
| S399 | Phosphorylation | Uniprot | |
| K417 | Ubiquitination | Uniprot | |
| S427 | Phosphorylation | Uniprot | |
| K443 | Ubiquitination | Uniprot | |
| S491 | Phosphorylation | Uniprot | |
| S494 | Phosphorylation | Uniprot | |
| S502 | Phosphorylation | Uniprot | |
| T507 | Phosphorylation | Uniprot | |
| S517 | Phosphorylation | Uniprot | |
| R518 | Methylation | Uniprot | |
| S530 | Phosphorylation | Uniprot | |
| Y532 | Phosphorylation | Uniprot | |
| S534 | Phosphorylation | Uniprot | |
| Y539 | Phosphorylation | Uniprot | |
| S551 | Phosphorylation | Uniprot | |
| Y552 | Phosphorylation | Uniprot | |
| S558 | Phosphorylation | Uniprot | |
| S568 | Phosphorylation | Uniprot | |
| Y578 | Phosphorylation | Uniprot | |
| Y587 | Phosphorylation | Uniprot | |
| S598 | Phosphorylation | Uniprot | |
| S599 | Phosphorylation | Uniprot | |
| R602 | Methylation | Uniprot | |
| S604 | Phosphorylation | Uniprot | |
| S608 | Phosphorylation | Uniprot | |
| S612 | Phosphorylation | Uniprot | |
| R616 | Methylation | Uniprot | |
| S618 | Phosphorylation | Uniprot | |
| S619 | Phosphorylation | Uniprot | |
| S636 | Phosphorylation | Uniprot | |
| T638 | Phosphorylation | Uniprot | |
| Y639 | Phosphorylation | Uniprot |
研究背景
May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK.
Undergoes deimination of some arginine residues (citrullination).
Cell membrane.
Note: Located on plasma membrane of neuroblastoma NMB7 cells.
The source of this protein is neonatal foreskin. The 67-kDa type II keratins are expressed in terminally differentiating epidermis.
Heterotetramer of two type I and two type II keratins. Heterodimer with KRT10. Two heterodimers of KRT1 and KRT10 form a heterotetramer. Interacts with ITGB1 in the presence of RACK1 and SRC, and with RACK1. Interacts with C1QBP; the association represents a cell surface kininogen receptor. Interacts with EPPK1; interaction is dependent of higher-order structure of intermediate filament.
Belongs to the intermediate filament family.
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