製品: PAK1IP1 Antibody
カタログ: DF2563
タンパク質の説明: Rabbit polyclonal antibody to PAK1IP1
アプリケーション: WB IHC IF/ICC
反応性: Human, Mouse
分子量: 48 kDa; 44kD(Calculated).
ユニプロット: Q9NWT1
RRID: AB_2839769

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製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse
クローナリティ:
Polyclonal
特異性:
PAK1IP1 Antibody detects endogenous levels of total PAK1IP1.
RRID:
AB_2839769
引用形式: Affinity Biosciences Cat# DF2563, RRID:AB_2839769.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ/展開

bA421M1.5; FLJ20624; hPIP 1; hPIP1; MAK 11; MAK11; p21 activated protein kinase interacting protein 1; PAK- AND PLC-INTERACTING PROTEIN 1; PAK/PLC interacting protein 1; PAK1 interacting protein; PAK1IP1; PIP 1; PIP1; Putative PAK inhibitor Skb15; RP11 421M1.5; WD repeat containing protein 84; WDR 84; WDR84;

免疫原

免疫原:
Uniprot:
遺伝子(ID):
発現特異性:
Q9NWT1 PK1IP_HUMAN:

Expressed in brain, colon, heart, kidney, liver, lung, muscle, peripheral blood leukocytes, placenta, small intestine, spleen and thymus.

タンパク質配列:
MELVAGCYEQVLFGFAVHPEPEACGDHEQWTLVADFTHHAHTASLSAVAVNSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGNRHLISGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRSAFIKNIKQNAHIVEWSPRGEQYVVIIQNKIDIYQLDTASISGTITNEKRISSVKFLSESVLAVAGDEEVIRFFDCDSLVCLCEFKAHENRVKDMFSFEIPEHHVIVSASSDGFIKMWKLKQDKKVPPSLLCEINTNARLTCLGVWLDKVADMKESLPPAAEPSPVSKEQSKIGKKEPGDTVHKEEKRSKPNTKKRGLTGDSKKATKESGLISTKKRKMVEMLEKKRKKKKIKTMQ

PTMs - Q9NWT1 基板として

Site PTM Type Enzyme
K70 Acetylation
K111 Acetylation
S118 Phosphorylation
T127 Phosphorylation
S130 Phosphorylation
K145 Ubiquitination
K161 Ubiquitination
S173 Phosphorylation
Y179 Phosphorylation
S214 Phosphorylation
S320 Phosphorylation
S323 Phosphorylation
T337 Phosphorylation
K363 Ubiquitination
S365 Phosphorylation
S369 Phosphorylation
K372 Acetylation
K381 Acetylation

研究背景

機能:

Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly.

細胞の位置付け:

Nucleus>Nucleolus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Expressed in brain, colon, heart, kidney, liver, lung, muscle, peripheral blood leukocytes, placenta, small intestine, spleen and thymus.

サブユニット構造:

Interacts with PAK1.

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