PAK1IP1 Antibody - #DF2563
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF2563, RRID:AB_2839769.
折りたたみ／展開
bA421M1.5; FLJ20624; hPIP 1; hPIP1; MAK 11; MAK11; p21 activated protein kinase interacting protein 1; PAK- AND PLC-INTERACTING PROTEIN 1; PAK/PLC interacting protein 1; PAK1 interacting protein; PAK1IP1; PIP 1; PIP1; Putative PAK inhibitor Skb15; RP11 421M1.5; WD repeat containing protein 84; WDR 84; WDR84;
免疫原
Expressed in brain, colon, heart, kidney, liver, lung, muscle, peripheral blood leukocytes, placenta, small intestine, spleen and thymus.
- Q9NWT1 PK1IP_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MELVAGCYEQVLFGFAVHPEPEACGDHEQWTLVADFTHHAHTASLSAVAVNSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGNRHLISGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRSAFIKNIKQNAHIVEWSPRGEQYVVIIQNKIDIYQLDTASISGTITNEKRISSVKFLSESVLAVAGDEEVIRFFDCDSLVCLCEFKAHENRVKDMFSFEIPEHHVIVSASSDGFIKMWKLKQDKKVPPSLLCEINTNARLTCLGVWLDKVADMKESLPPAAEPSPVSKEQSKIGKKEPGDTVHKEEKRSKPNTKKRGLTGDSKKATKESGLISTKKRKMVEMLEKKRKKKKIKTMQ
PTMs - Q9NWT1 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K70 | Acetylation | Uniprot | |
| K111 | Acetylation | Uniprot | |
| S118 | Phosphorylation | Uniprot | |
| T127 | Phosphorylation | Uniprot | |
| S130 | Phosphorylation | Uniprot | |
| K145 | Ubiquitination | Uniprot | |
| K161 | Ubiquitination | Uniprot | |
| S173 | Phosphorylation | Uniprot | |
| Y179 | Phosphorylation | Uniprot | |
| S214 | Phosphorylation | Uniprot | |
| S320 | Phosphorylation | Uniprot | |
| S323 | Phosphorylation | Uniprot | |
| T337 | Phosphorylation | Uniprot | |
| K363 | Ubiquitination | Uniprot | |
| S365 | Phosphorylation | Uniprot | |
| S369 | Phosphorylation | Uniprot | |
| K372 | Acetylation | Uniprot | |
| K381 | Acetylation | Uniprot |
研究背景
Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly.
Nucleus>Nucleolus.
Expressed in brain, colon, heart, kidney, liver, lung, muscle, peripheral blood leukocytes, placenta, small intestine, spleen and thymus.
Interacts with PAK1.
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